[Fever of unknown origin: a diagnostic algorithm].
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Diagnosis, Differential↗
Biomedical subjects
Publications and source records attributed to V E Mitrokhin.
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It was found that a hypotensive effect of penbutolol used for treatment of 234 patients with hypertensive disease exceeded that of propranolol and developed at a dose of 20-80 mg a day at the end of the 2nd week of treatment. Penbutolol produces a less negative chronotropic effect as compared to propranolol. The excess of penbutolol therapeutic dose leads to the further augmentation of a positive clinical effect.