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Biomedical subjects

V E Parfenov

Publications and source records attributed to V E Parfenov.

16 recordsLinked to original sources
PubMed2005

[Surgical treatment of lung cancer patients with brain metastases].

The authors present an experience with diagnosing and treatment of 16 patients suffering from lung cancer with solitary metastasis into the brain. The examination performed has shown that in 7 out of 16 patients the surgical treatment was found to be not expedient. This solution was based on the detection of an extensive spread of lung cancer: multiple metastasis outside the thoracic cavity and the brain or inside the brain, and in one case--due to a considerable reduction of indices of the functional and reserve capacities of respiration and blood circulation. Single-step operations were carried out in 9 patients with lung cancer with a solitary metastasis into the brain (resection of the lung with an ablation of the brain metastasis). Out of the 9 patients operated on 6 patients survived for as long as 1.5 to 2 years, one patient lived longer than 4 years. Two other patients operated upon in June 2003 and March 2004 are still alive and feel much better. Satisfactory results of treatment of these patients show such methods to be expedient.

Adenocarcinoma↗
PubMed1998

[Video endoscopy in neurosurgery].

The authors present an analysis of their experiences with performing more than 330 video endoscopic operations on the autopsy material and in 172 patients. In 54 of these patients operations were performed for traumatic intracranial convex hematomas, in 21 for adenomas of the hypophysis, in 14--for arterial aneurysms, and 53 patients with discogenic radiculitis, spinal tumors, consequences of severe spinal traumas. In 25 patients the endoscopic videomonitoring was made during excision of the tumors, paratumorous cysts and abscesses of the brain, decompression of the optic nerve, plasty of the anterior cranial fossa fundus with closing the liquor fistulas. Intraoperative angioscopy in carotid endarterectomy was fulfilled in 5 patients. The video endoscopy was proved to result in less traumaticity of the radical surgery. It is a valuable and highly informative method giving optimum results in performing many microsurgical operations.

Adult↗
PubMed1998

[The combined use of intraoperative video endoscopy and contact microvascular dopplerography in the surgery of cerebral aneurysms].

The article describes results of an anatomo-clinical investigation using video-endoscopy and contact microvascular dopplerography in surgery of cerebral aneurysms. The endoscopic anatomy of cisterns of the cerebral base was studied in 36 corpses of adult humans. More than 200 video-endoscopic operative interventions were performed on sectional material. Video-endoscopy in combination with contact microvascular dopplerography was conducted in the clinic on 20 patients with aneurysms of the brain. Main advantages of endoscopy used in combination with microvascular dopplerography during clipping the aneurysm are formulated. Complex using the two methods described gives less volume of the access and traumaticity of the intervention but not less radical effect. It is a valuable and highly informative method which optimizes performing the operation and has less amount of postoperative complications.

Adult↗
PubMed1995

[The diagnosis of arteriovenous malformations of the brain by transcranial dopplerography (the dopplerographic semeiotics of arteriovenous malformations)].

The work is devoted to investigation of possible use of transcranial dopplerography as a method of noninvasive diagnosing of arteriovenous malformations of the brain. An analysis of results of investigations in 89 patients with suspected arteriovenous malformations was made. A close correlation is confirmed between the parameters of the blood flow and the volume, diameter and type of the structure of the supplying arteries. Transcranial dopplerography was shown to allow the detection of arteriovenous shunts in the brain vessels which is one of main symptoms of the arteriovenous malformations.

Adolescent↗
PubMed1995

[The diagnosis of arteriovenous malformations of the brain by transcranial dopplerography (the potentials of complex noninvasive neurosonoradiological diagnosis)].

Under analysis were results of diagnostics in 89 patients with suspected arteriovenous malformations (AVM) obtained by the method of ROC-analysis. The examination included computed tomography (CT) and transcranial dopplerography (TCDG) performed by the standard method. The total sensitivity of TCDG in diagnosing AVMs as a nosological form was 89.5% which is considerably higher than the possibilities of CT. Malformation having a torpid course were diagnosed correctly reliably more often (100%) than those with hemorrhagic debut (78.6%). Most perspective is the principle of unity of "morphological" and functional methods of noninvasive diagnostics. Sensitivity of the complex diagnostics of AVMs was 92.9%, diagnostics of malformations with a torpid course being without errors.

Cerebral Angiography↗
PubMed1989

[The reactivity of the major vessels of the human brain based on the data of transcranial dopplerography].

Clinico-physiological studies of 426 healthy subjects revealed normal parameters of the blood flow linear velocity along the extra- and intracranial portions of major cerebral vessels as determined by means of transcranial dopplerography. Normal parameters of the systolic-diastolic coefficient, the reactivity of major vessels and their pial draining network were studied in respect to their responses to functional loads of physical and chemical character which enabled one to determine functional possibilities of the cerebral circulation system. The ability of the dopplerographic technique was assessed in respect to studying of separate control mechanisms of the brain circulation system.

Adult↗
PubMed1989

[Ways to optimize the cerebral circulation during extreme actions on the brain].

The effect of mildronate (25 mg/kg, i.v.) administration during 14 days on the restoration of cerebral blood flow and vascular reactivity after local lesions and ischemia, was studied in rabbits. The effect involved an improvement of restorative processes due to a faster normalizing of reactivity of cerebral vessels. The latter seems to be more important for optimization of cerebral blood flow after extreme effects than the absolute level of the cerebral blood flow.

Animals↗
PubMed1988

[Dynamics of the cerebral blood flow and reactivity of the cerebral vessels after bilateral occlusion of the carotid arteries].

A model of cerebral ischemia was implemented by means of bilateral occlusion of carotid arteries in rabbits. A reduction of the blood flow was observed during first 3 days after the occlusion in the cortex and white matter, followed by a slow restoration up to 80 per cent of initial level. The responses of the blood flow to CO2 were reduced and often inverted during the 1st week, had a phasic character and returned to near normal by the 14th day. The responsiveness of vessels to CO2 and head-down tilt were sharply reduced and inverted during the 1st week and did not return to normal. Simultaneous recording of the blood flow parameters and of the responsiveness of cerebral vessels provides a better insight into the dynamics of postischemic restoration of functional state of various parts of the brain vascular system.

Animals↗
PubMedDate not supplied

[The potentials of current methods for the radiodiagnosis of cerebral arteriovenous malformations].

The potentialities of current Neuroimaging methods were established to allow one to make an early minimally invasive diagnosis of arteriovenous [correction of arterioventricular] malformations. The most promising method is a combined use of X-ray computer and magnetic resonance tomography with transcranial Doppler echography, which is in conformity with the unity principle of morphological and functional non-invasive diagnostic methods. At present, cerebral angiography should be used only in combination with preoperative examination of these patients.

Cerebral Angiography↗
PubMedDate not supplied

[Dopplerographic assessment of the autoregulation of the blood supply to the brain in neurosurgical pathology].

The development of an informative, noninvasive technique for evaluating the reserve of the cerebral circulatory system is a topical task of clinical angioneurology. The authors developed methods of Doppler evaluation of an autoregulatory response from hyperemic changes after short-term regional hypotension caused by digital compression of the cervical carotid. They calculated the indices acceptable in routine clinical practice, defined the range of their values in health and in typical variants of cerebral circulatory insufficiency in patients with disseminated neurosurgical pathology. The carotid compression test by recording linear blood flow velocity in the cerebral arteries is a safe, valid, and reproducible method of semiquantitative assessment of the autoregulation reserve which may be used to determine the tension of resistive vessels in the middle cerebral arterial bed as an important index of the functional status of the cerebral circulatory system.

Adolescent↗