PubMed Health⌕ Search

Biomedical subjects

V E Pastorova

Publications and source records attributed to V E Pastorova.

At least 19 recordsLinked to original sources
PubMed1992

[Fibrinolytic complexes of low-molecular heparin and acetylsalicylic acid].

Complexes of low-molecular heparin with acetylsalicilic acid was formed in vitro when the weight ratio of components was 1:1, 1:5 and 5:1, respectively. All the complexes possessed fibrinolytic and anticoagulating activities. The complex possessed the highest activity when the ratio of heparin to acetylsalicilic acid was 5:1. This complex at a dose 1 mg/200 g of rat weight had the largest thrombolytic effect on the experimental fresh thrombus.

Animals↗
PubMed1990

[A method of determining the anti-, de- and fibrin-polymerization activity of the blood plasma].

The suggested method is based on measuring the changed level of polymerized fibrin monomer and nonstabilized fibrin under the effects of agents enhancing or inhibiting fibrin monomer polymerization. This method permits measurement of plasma specific activity influencing fibrin monomer and unstabilized fibrin polymerization in human and animal blood plasma in health and various diseases involving disorders of hemostasis system, as well as in various drug exposures.

Animals↗
PubMed1990

[Platelet aggregation induced by fibrinmonomer and the effect of the heparin-adrenaline complex or plasmin on this process].

Addition of purified fibrin-monomer in a concentration of 0.5 mg/ml induces aggregation in a suspension of washed rat platelets in the absence of aggregants. Maximum aggregation takes place 1-3 min after fibrin-monomer addition, and then the disaggregation phase follows. Complex heparin compounds with adrenalin or plasmin possessing antipolymerization and fibrinolytic activity with respect to ++non-stabilized fibrin prevent, or to a great extent decrease fibrin-monomer-induced aggregation of washed platelets.

Animals↗
PubMed1990

[Process of fibrin depolymerization and non-enzymatic fibrinolysis in rabbits receiving atherogenic rations with addition of antioxidants].

The rabbits were kept on atherogenic ration for 2 months. This diet contained 0.3 mg/kg of cholesterol. In blood plasma of animals the authors observed a sharply reduced non-enzymatic fibrinolysis and depolymerization activity of non-stabilized fibrin. The addition of antioxidants and alpha-tocopherol (10 + 10 mg/kg) for 1 month to the atherogenic ration protected from the disturbance of the system hemostasis and normalized the depolymerization of non-stabilized fibrin.

Animals↗
PubMed1988

[Effect of a complex mixture of plasma proteins with heparin on the anticoagulation and fibrinolytic activity of the blood plasma in animals following intravenous administration of tissue thromboplastin].

The i.v. administration of 1.5 ml of the heparin complexes with plasma proteins prior to the injection of tissue thromboplastin induced a stronger neutralization of formed thrombin in the blood and higher anticoagulating and fibrinolytic activities in albino rats as compared to the injection of tissue thromboplastin alone.

Animals↗
PubMed1986

[Formation of thrombin and its inactivation by antithrombin III following repeated intravenous injections of tissue thromboplastin in animals].

A breach in the inactivation of thrombin activity by antithrombin III following numerous repeated intravenous injections of tissue thromboplastin to albino rats was established. Seven injections of tissue thromboplastin to animals (at 30-40 min-interval) caused functional exhaustion of anticoagulation system and increased thrombin blood circulation level.

Animals↗
PubMed1986

[Effect of complexes of heparin with plasma proteins on the anticoagulant and fibrinolytic activity of blood].

Mixture of heparin complexes with plasma proteins of the rat blood with no fibrinogen, prothrombin or factors of prothrombin complex obtained either in presence or absence of CaCl2, revealed strong anticoagulating, fibrinolytic, antiaggregating and antipolymerizational activities. 1--2 mM CaCl2 solution increased the enzymatic and non-enzymatic activities of the mixture in vitro. The i.v. administration of the mixture to albino rats potentiated the anticoagulating and fibrinolytic activities of the blood plasma.

Animals↗
PubMed1985

[Anticoagulant and nonenzymatic fibrinolytic activity of plasma in animals after intravenous injection of a heparin-antithrombin III complex].

The heparin-antithrombin III complex with a weight ratio 1:3 had a powerful anticoagulant and non-enzymatic fibrinolytic activity in vitro. Seven and 30 min after intravenous injection of the complex the animal blood plasma showed a considerable prolongation of the thrombin time and an increase in non-enzymatic fibrinolytic activity. The effect of heparin injected in a dose equivalent to its content in the complex on the parameters under study was appreciably less and disappeared by the 30th minute of the observation period.

Animals↗
PubMed1984

[Nonenzymatic fibrinolytic reaction to the intravenous administration of small doses of Salmonella endotoxin to rabbits].

Intravenous injection of a low dose of Salmonella endotoxin (10 micrograms/kg bw) into rabbits results in an increase in the non-enzymatic fibrinolytic activity of blood at early stages of a pathological process followed by depression of this response at later stages of the pathology. At higher degrees of non-enzymatic fibrinolysis activation the morphological and ultrastructural changes in renal tissues caused by endotoxin injection are the least pronounced. Intravenous injection of heparin after injection of a lethal dose of Salmonella endotoxin (100-200 micrograms/kg) enhances non-enzymatic fibrinolysis activation and decreases the morphological and ultrastructural lesions in renal tissues.

Animals↗
PubMed1984

[Antithrombin III activity in long-developing hypercoagulation in animals].

Old rats aged 12-18 months and rats kept on an atherogenic diet for 3.5 months demonstrate high blood antithrombin III content at the initial period of the development of anticoagulation function suppression and of hypercoagulation. During long-developing hypercoagulation, the high content of antithrombin III might be regarded as compensatory reaction interfering with formation in the blood of thrombin microamounts. With hypercoagulation becoming more pronounced and with a further increase of blood thrombin concentration the content of antithrombin III progressively descends, which is accompanied by steady development of anticoagulation function suppression.

Aging↗
PubMed1983

Anticoagulating and non-enzymatic fibrinolytic activities of heparin-antithrombin III and antithrombin III-heparin-thrombin complexes in vitro and in vivo.

The heparin-antithrombin III and antithrombin III-heparin-thrombin complexes were prepared in vitro. The formation of complexes was controlled by crossed electrophoretic and spectrophotometric methods. All the binary and ternary complexes prepared at the weight ratio of components 1: 1: 1 and at some other weight correlations were active as non-crosslinked fibrin solvents and kept this activity in the presence of inhibitors of plasmin fibrinolysis. A considerable prolongation of thrombin time and an increasing of total and in particular non-enzymatic lytic actions of plasma were achieved in 7 and 30 min after intravenous injection of 1 ml 0.1-0.2% solution of heparin-antithrombin III complex in rats. The obtained results of experiments allow to conclude that the heparin-antithrombin III and antithrombin III-heparin-thrombin complexes possess the non-enzymatic fibrinolytic action on non-crosslinked fibrin. The degree of this activity is dependent on the quantitative correlation of heparin-antithrombin III or antithrombin III-heparin-thrombin concentrations during the reaction of complex formation.

Animals↗