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Biomedical subjects

V E Sinitsyn

Publications and source records attributed to V E Sinitsyn.

At least 19 recordsLinked to original sources
PubMed1992

[Anaerobic threshold in patients with chronic circulatory insufficiency].

To evaluate the severity of chronic circulatory insufficiency (CCI), 12 healthy subjects and 69 patients with cardiovascular diseases underwent exercise testing. Parameters such as anaerobic threshold (AT) and peak oxygen consumption (peak VO2) were measured by respiratory gas analysis to assess the circulatory insufficiency. AT decreased with an increase in New York Heart Association functional class and amounted to 18.9 +/- 4.3, 14.5 +/- 3.5, 11.6 +/- 2.9, and 7.5 +/- 2.0 ml/min/kg in Classes 1, 2, 3, 4, respectively. The peak VO2 decreased as hCCI progressed. The findings suggest that the parameters of external respiration and gas exchange are closely associated with CCI pathophysiology. The parameters may be used as objective and valid criteria for the severity of CCI and its dynamics in the course of treatment.

Adult↗
PubMed1991

[MR-tomography of the heart in cardiomegaly caused by dilated cardiomyopathy and ischemic heart disease].

The paper deals with the results of magnetic resonance cardiac tomography in 19 patients with dilated cardiomyopathy and 10 patients with coronary heart disease who had severe cardiomegaly and congestive heart failure symptoms. Magnetic resonance tomography showed that the patients with dilated cardiomyopathy exhibited profound dilatation of all the 4 cardiac cavities and a chaotic pattern of impaired segmental left ventricular contractility, whereas those with coronary heart disease had predominant dilatation of the left cavity and local myocardial dysfunctions. Magnetic resonance may be one of the non-invasive tools which make the genesis of cardiomegaly clear in patients with heart failure.

Adult↗
PubMed1991

[Magnetic resonance tomography of the heart in dilated cardiomyopathy].

NMR-tomography using a spin-echo technique, ECG synchronization in exposure to 0.23 T magnetic field was performed in 13 patients with dilated cardiomyopathy (DCMP). The results were correlated with echocardiography findings. NMR-tomography provided a good image of cardiac chambers dilatation, their size being in agreement with that shown by echocardiography. No significant differences in myocardial relaxation time T2 was recorded in DCMP patients compared to normal subjects. NMR-tomography can be successfully employed in cardiac investigations in case of complicated echocardiography.

Adult↗
PubMed1991

[Use of magnetic resonance tomography in cardiology].

The authors review the problems of the use of MR tomography (MRT) in cardiology on the basis of experience gained with examination of 1131 patients. It is pointed out that the use of MRT is most desirable in congenital diseases of the heart and vessels, aortal aneurysms, para- and intracardial formations. In CHD, cardiomyopathies, pericarditis and congenital heart diseases, MRT can be employed provided the other noninvasive research methods (primarily echocardiography) are of insufficient information content. In addition to investigations into diseases of the heart and vessels, MRT can be applied to examinations of the kidneys, adrenals and brain in patients suffering from arterial hypertension. The merits and shortcomings of MRT are discussed as compared to the other instrumental research methods allowing organ images to be obtained.

Aneurysm↗
PubMed1990

[Modern methods for the instrumental diagnosis of intracavitary thrombosis of the left ventricle in myocardial infarct].

To study the sensitivity and specificity of two-dimensional echocardiography in the diagnosis of left ventricle thrombosis which often attends myocardial infarction and to define diagnostic potentialities of the new research methods (digital subtraction ventriculography and MR tomography), 449 patients with acute transmural myocardial infarction were examined. Based on the comparison of the echocardiographic readings and morbid anatomy data it has been shown that the sensitivity of two-dimensional echocardiography in revealing left ventricle thrombosis amounts to 89%, specificity to 88%. Digital subtraction ventriculography has a lower (77%) sensitivity, with the specificity being satisfactory enough (88%). Meanwhile MR tomography enables a highly precise diagnosis of left ventricle thrombosis and can be used as a supplementary diagnostic method in questionable cases and in thrombi small in size or in unsatisfactory ultrasonic visualization of the heart structures.

Echocardiography↗
PubMed1990

[The clinical application of new methods of magnetic resonance tomography].

MR-tomography was used for investigation of 129 patients with various diseases of the kidneys, liver, pancreas, organs of the small pelvis, brain and spinal marrow. Possibilities of the use and practical value of new MRT methods--MR-urography and MR-myelography (MRu and MRm) were studied. They made it possible to detect within a short period of time (40-60 sec.) the presence of fluid in an examined volume. MRu was the most informative method in cystic lesions of various organs looking like round-shaped formations with a high intensity signal. MRm was highly informative in the diagnosis of syringomyelia, informative for the determination of the state of the brain ventricular system. MRm performed in different planes and their summation with images of common MR-sections makes the interpretation of the obtained data much easier. MRm is desirable in suspected fluid in an examined volume or in order to specify the state of the cerebral liquor system.

Adolescent↗
PubMed1990

[The determination of ventricular myocardial mass by magnetic resonance tomography].

MR-tomography (MRT) was used to investigate 10 isolated hearts from patients who died of various cardiovascular diseases. The purpose was to study the accuracy of MRT for determination of the myocardial mass (MM) of the left and right ventricles. MM was calculated using Simpson's method and the "area-length" formula. The first method demonstrated a high correlation of MRT results with autopsy findings with relation to the left, right ventricles and the interventricular septum (r = 0.98, 0.88, 0.85, respectively). The accuracy of the second method was also very high (r = 0.96 with relation to the left ventricle), however great scattering of MM values with relation to true values was noted. MRT can serve as a highly informative method in the evaluation of the ventricular MM and the time course of its changes.

Adult↗
PubMed1989

[Clinical use of magnetic resonance tomography in the assessment of vital organs in malignant arterial hypertension].

Magnetic resonance tomography was performed to examine the kidneys, brain, adrenals, vessels, and heart in 110 patients with malignant arterial hypertension (MAH). The findings were compared with those of the examination of healthy subjects and patients with benign hypertensive disease (BHD). As compared to the controls, all the MAH patients had changes in the target organs, however, their nature and magnitude varied with under underlying MAH disease. Renal alterations were most profound in chronic glomerulonephritis. All the patients displayed signs of concentrated cardiac hypertrophy: its maximum degree being noted in renovascular hypertension, the least, in MAH of adrenal genesis. Examination of the central nervous system in MAH patients revealed that the ventricular system and subdural space were dilated. It was shown that it was feasible to diagnose hypertrophic encephalopathy in the prehospital period by employing magnetic resonance tomography.

Adolescent↗
PubMed1989

[Magnetic resonance tomography of the heart in hypertrophic cardiomyopathy].

The authors provide the results of the use of magnetic resonance tomography (MRT) in examining 20 patients suffering from hypertrophic cardiomyopathy (HCMP). MRT was made using an apparatus with a field force of 0.23 synchronized with the ECG. The MR-sections were performed both in transverse and inclined planes oriented along the long axis of the left ventricle. MRT made it possible to identify and to assess with a high accuracy asymmetric hypertrophy of the left ventricle myocardium including the cases with apical localization of hypertrophy. Analysis of the data showed a certain decrease of the left ventricle cavity in the systole, dilatation of the left atrium and pronounced hypertrophy of the myocardium (mainly of the interventricular septum). The asymmetry coefficient amounted to 2.1. Correlation of the MRT data and two-dimensional ultrasound cardiography readings demonstrated good comparability of the results obtained with the use of both methods. MRT can be applied in the diagnosis of HCMP in cases where it is difficult to carry out ultrasound cardiography as well as for diagnosis verification provided the results derived with the use of other research methods are inconclusive.

Adolescent↗
PubMed1988

Potentiation of platelet interaction with collagen substrates by heparin is insensitive to aspirin.

The effects of two standard, unfractionated heparin preparations on collagen-induced adhesion and aggregation of platelets were studied by Born aggregometry and scanning electron microscopy (SEM). Heparin from porcine intestinal mucosa (HI) and from bovine lung (HL) added to human PRP in the concentration of 2.5 to 5.0 U/ml (1) did not induce platelet aggregation in suspension by itself but stimulated it in combination with the subthreshold doses of fibrillar human collagen type III (CIII); (2) increased by 1.5-2.0 fold the adhesion, but did not affect platelet spreading on a surface coated with human collagen type IV (CIV); and (3) enlarged by 2.5-3.0 fold the area of the CIII-coated surface covered with aggregates, increasing both the number and the size of surface-bound aggregates. Aspirin blocked platelet aggregation in suspension induced by low, near threshold doses, of fibrillar CIII and by subthreshold doses of CIII in combination with heparin, but had no effect on platelet aggregation induced by high (greater than 10 threshold) doses of CIII. Aspirin failed to decrease platelet adhesion to and spreading on CIV substrate, and formation of surface-bound aggregates on CIII substrate in the absence as well as in the presence of heparin.

Aspirin↗
PubMed1988

[Magnetic resonance tomography of the heart in healthy persons].

Potentialities of MR-tomography of the heart were studied in 20 healthy persons. Synchronization with the cardiac cycle on ECG was used in 15 cases. The VMT-1100 MR-tomograph (Brucker, FRG) was employed. The spinecho technique was used. MR-tomography of the heart was performed in axial, sagittal, frontal and oblique planes with relation to the anatomical heart axes. All major heart structures and mediastinal vascular bundles were clearly visualized on MR-images obtained by means of synchronization with the cardiac cycle. In some cases pericardial zones and fragments of coronary arteries were seen. MR-tomography permitted imaging of the heart in a desired phase of the cardiac cycle. This method was shown to be highly informative, providing quality images of the cardiac chambers and walls in different planes, permitting their quantitative and qualitative assessment. Further improvement of the method and programs for it will permit raising its diagnostic potentialities in studies on the heart.

Adult↗
PubMed1988

[Magnetic resonance tomography of the heart in primary pulmonary hypertension].

MR-tomography (MRT) was performed in 10 patients with primary pulmonary hypertension (PPH) and in 20 healthy volunteers. The investigation was performed by means of a MR-tomograph with a resistive magnet. ECG-triggering and multislice-multiecho method were used. MRT gave high quality images of the right heart in various phases of the cardiac cycle. The most characteristic symptoms of PPH exhibited by MRT were: forward rotation of the right ventricle (RV), pronounced dilation of the right heart, right ventricular myocardial hypertrophy, relative and absolute diminishing of the left ventricle size, paradoxical motion of the interventricular septum and alterations in its shape. 50% of the examined patients had highly intensive blood flow signal in the pulmonary artery lumen.

Adult↗
PubMed1988

[Determining the linear dimensions of the heart in healthy persons by the method of magnetic resonance tomography].

Linear dimensions of hearts in 16 healthy volunteers obtained by magnetic resonance tomography (MRT) and 2-dimensional echocardiography (EchoKG) were compared. MRT was performed with BMT 1100 tomograph ("Bruker", FRG) with magnetic field strength of 0.235 T using EKG-triggering. Oblique slices through anatomic heart axes were registered. Good correspondence of MRT- and EchoKG-obtained linear dimensions of heart structures (r = 0.62-0.85) prove that MRT allows evaluation of dimensions of various heart structures as effectively as 2-dimensional EchoKG.

Adult↗