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Biomedical subjects

V ERSPAMER

Publications and source records attributed to V ERSPAMER.

At least 37 records · Page 2Linked to original sources
PubMed1960

The pharmacological actions of (m-hydroxyphenethyl) trimethylammonium (leptodactyline).

Leptodactyline is a naturally occurring quaternary ammonium base, which is found in large amounts in the skin of some South American amphibians of the genus Leptodactylus. It is the first example of a m-hydroxyphenylalkylamine in the living organism. In vertebrates it had powerful nicotinic actions and a marked neuromuscular blocking effect. This was considered, on the basis of experimental evidence, to be of the "depolarizing" type.

Ammonium Compounds↗
PubMed1958

The pharmacological actions of some murexine-like substances.

Four choline esters of imidazole acids, two imidazole ethers of choline and thirteen ringsubstituted murexine-like compounds were compared with murexine for their muscle-paralysing and their nicotine-like effects. Dihydromurexine appeared, in animal experiments, to be the most potent derivative, but it was shown to be less effective than murexine in man. Among the other compounds, imidazolebutyrylcholine and imidazolepropoxycholine appeared to be worthy of particular consideration. The relation between the chemical structure of the murexine-like substances studied and their pharmacological effects is discussed.

Anesthetics, General↗
PubMed1957

The pharmacological actions of murexine (urocanylcholine).

Murexine or urocanylcholine is a naturally occurring choline ester of urocanic acid which was found in very large amounts in the hypobranchial body of Murex trunculus and other prosobranchiate molluscs. In vertebrates and invertebrates, it was found to possess marked neuromuscular blocking and nicotinic actions, but was almost devoid of muscarinic effects. The blocking action of murexine was considered, on the basis of experimental and clinical evidence, to be of the "depolarizing" type. It was weaker than, but qualitatively very similar to, that produced by suxamethonium. The nicotinic action of murexine was stronger than that of suxamethonium in both experimental animals and human beings.

Animals↗