During 1978 to 1988, 35 patients with ear carcinoma (22 men and 13 women, aged 30 to 74 years) were treated. In 62% cases the tumor originated from the external acoustic meatus, in 30% cases--from the postoperative cavity (in patients operated on for chronic inflammation), and in 8% cases it was a primary tumor of the concha auriculae. 77% of the patients developed the III or IV stage of disease and 71% of patients had squamous cell carcinoma. Six patients underwent radiation therapy (Group 1), nine-radiation therapy and subsequent surgery within 14 to 30 days after exposure (Group 2), and twenty patients were exposed first to surgery and then to postoperative radiation therapy (Group 3). All the patients were followed up for at least one year and eight of them--for not less than 5 years. At the present time survivors make 37% of all the patients. In the study only routine dose fractionation was used. Regional metastatic areas were also exposed to irradiation. It is stressed that efforts are needed to increase the local effect of ear tumor therapy. Indications and contraindications for radiation therapy are presented and protocols of radiation therapy are described.

Adult↗

PubMedDate not supplied

[Adoptive laser immunotherapy and photodynamic therapy in ORL oncology].

Present-day developments in oncological applications of laser therapy are adaptive laser immunotherapy (ALIT) and photodynamic therapy (PDT). ALIT (helium-neon laser) was used in 35 ENT-cancer patients to irradiate immunocompetent leukocytes isolated from blood in an Amino cell separator. The use of ALIT in the combined treatment of our patients improved their health condition. Cytological, immunochemical and immunological examinations of blood revealed an increased count of activated lymphocytes, normalization of acute-phase proteins, stimulation of cell-mediated immunity and nonspecific resistance. The pharmacokinetics and photodynamic activity of porphyrin compounds in mice with inoculated tumors were investigated. Experimental observations demonstrated that the application of photodynamic therapy of hematoporphyrins in ENT-oncology seems very promising.

Animals↗

PubMedDate not supplied

[Computerized tomography in diseases of the frontal sinus].

Thirty-seven patients (15 women and 22 men), aged 22 to 67 years, with various frontal sinus pathologies were examined. The pathology was unilateral in all the patients. The following pathologies were identified: mucocele of frontal sinuses--2 cases; mucocele of the frontoethmoid area--4 cases; acute frontitis--5 cases; exacerbation of chronic frontitis (state after frontoethmoid trepanation)--14 cases; suppurative hemisinusitis--7 cases; frontal sinus cyst--2 cases; frontal sinus osteoma--3 cases. Final diagnosis was made with the aid of computer tomography because routine tomography proved inadequate. Computer tomography made it possible to clarify the state of the posterior and upper walls of the frontal sinus in the case of inflammation, mucocele, cysts, and osteomas and thus helped to elaborate adequate conservative or surgical therapy.

Adolescent↗

PubMedDate not supplied