[A protective mask of the virologist].
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Humans↗
Biomedical subjects
V F Popov
Publications and source records attributed to V F Popov.
[A morphological and immunofluorescent study of the measles vaccinal process in an experiment on monkeys].
A correlation between localization of morphological lesions and the presence of viral antigen in the CNS was established. Dissemination of the infectious process in the CNS depended on both topography of the inoculated areas and more so on traumatic injury of the ventricular system. Viral antigen could be detected in the reticuloendothelial system and epithelial cells of the respiratory tract without inducing specific cytopathic changes. Simultaneous morphological and immunofluorescent examination allowed the safety of live measles vaccine to be established more accurately.
Animals↗
[Evaluation of the reactivity and antigenic activity of the live measles vaccine, Leningrad-16, in different regions].
The reactogenicity and antigenic activity of live measles vaccine prepared from strain Leningrad-16 were assessed for 4 territories, two of which were exposed to radiation contamination as a result of the Chernobyl accident. The study was carried out at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. The vaccine was weakly reactogenic in all the regions; no grave or uncommon reactions to its administration were observed. Serologic studies revealed a high antigenic activity of the vaccine. The level of seroconversion was estimated as 98.5%. The study failed to detect any appreciable effect of radiation contamination on the tolerance to vaccine or level of immune response.
Antigens, Viral↗
[Comparative testing of live measles vaccines manufactured in France, Japan, and Russia].
Live measles vaccines prepared from different strains in France, Japan, and Russia were compared at the L. A. Tarasevich State Institute for Standardization and Control of Viral Preparations. Clinical reactions to the tested vaccines were studied in 181 children seronegative before vaccination. Vaccinal reactions to French, Japanese, and Russian were observed in 24.2, 26.5, and 5.9% vaccinees, respectively. The French and Russian vaccines virtually did not differ by the level of seroconversion (96 and 98.1%, respectively). For the Japanese vaccine the level of sero-conversion was lower: 91.6%. The mean titers of antibodies in vaccinees immunized with the French, Japanese, and Russian vaccines were, respectively, 7.36 +/- 0.91, 2.07 +/- 0.42, and 4.40 +/- 0.42 IU.
Antibodies, Viral↗
[Comparative study of methods for determining antibodies to measles virus].
The authors have developed enzyme immunoassay (EIA) for detecting antimeasles antibodies in the serum and compared it to routine methods. Preparation and purification of measles virus antigen used in EIA and optimal conditions of the reaction are described. Results of the routine methods and those of EIA correlated. EIA was used to determine titers of antimeasles antibodies in the sera of vaccinated children. 3-4 years after the vaccination the antibodies were undetectable in the sera of 23% of children.
Animals↗
[The quality and efficacy of a Russian live mumps vaccine].
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Animals↗
[Study and assessment of the antigenic activity and reactivity of rubella vaccine].
A total of 3422 adolescent girls and women of a reproductive age were vaccinated against rubella with French vaccine. Antigenic activity and reactogenicity of the vaccine were assessed in 97 girls, 100% seroconversion and weak reactogenicity was observed in seronegative vaccinees.
Adolescent↗
[Rubella in Russia: the detection of congenital rubella and the vaccination strategy and procedures].
The work on the evaluation of the role of rubella infection in the development of congenital malformations in newborn infants, as well as the immunogenic activity and tolerability of live attenuated vaccine Rudivax (Pasteur Mérieux Connaught) was carried out in the process of selective immunization in the Perm region. The study made it possible to find out 15% of malformations in the structure of the congenital pathology of newborn infants, which appeared due to the infection of the fetus with rubella virus and were manifested by multiple development defects, congenital C.N.S. defects and valvular defects. The results of using vaccine Rudivax in the epidemiological trial demonstrated that the vaccine had high immunological activity and was well tolerated. The absence of postvaccinal complications after the injection of the live vaccine and the absence of the extinction of immunity in the presence antibodies were indicative of the possibility vaccination without preliminary serological examination.
Adolescent↗