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V F Prokof'ev

Publications and source records attributed to V F Prokof'ev.

15 recordsLinked to original sources
PubMed2001

[Immunogenetic aspects of duodenal ulcer in Helicobacter pylori positive Europeans in Western Siberia].

AIM: To study HLA associations with HP-positive duodenal ulcer (DU). MATERIAL AND METHODS: A total of 47 Europeoid DU and 680 healthy subjects were examined for class I and II HLA antigens. Typing of class I antigens was conducted in the microlymphocytotoxicity test, of class 2 antigens--by polymerase chain reaction. RESULTS: The study has found associations of duodenal ulcer with HLA-A10, -B41 and different combinations of these alleles whereas HLA-A9 was protective. A relative risk of peptic ulcer was 3.03 in HLA-A10 (pcor < 0.05) and 7.78 in HLA-B41 (p < 0.001). The allele A9 occurred more frequently in healthy controls (30.15%) than in Helicobacter pylori-positive patients with DU (10.64%, RR = 3.50, pcor < 0.05). Frequencies of alleles HLA-DR7 and HLA-A1/B12 were higher in HP-positive DU patients with family history of peptic ulcer (RR = 4.00 and RR = 11.92, respectively, p < 0.05). CONCLUSION: These data suggest that HLA may influence duodenal ulcer susceptibility and resistance. The relationships help prognosticate not only development of the disease in HP infection but also the age of the infection manifestation.

Adult↗
PubMed1998

[Frequency of the HLA-DP genes and the antigens of the HLA-A, -B, -Cw, and -DR loci in Tuvinians].

The results of DNA typing of the HLA-DPB1 gene among Tuvinians are described. The allele 0201 was found to be the most frequent (26.66%); then, in order of decreasing frequency, followed the alleles 0401 (26.42%), 0402 (13.99%), 0301 (8.55%), 0501 (7.77%), 0901 (5.16%), and 1301 (2.07%). The frequency of the allele 0501 in Tuvinians was significantly lower than that in the published data on allele distributions characteristic of two other Mongoloid populations, the Manchu and Japanese. The results of the serological typing of the loci HLA-A, -B, and -Cw of class I in the Tuva population were compared to the corresponding published data on ten Mongoloid populations of Central and Eastern Asia: Uigurs, Kazakhs, Mongols, Manchu, Tibetans, the Chinese of the northern and southern regions of China, Thais (inhabitants of Northwestern Indochina), Koreans, and Japanese. In Tuvinians, the most frequent antigens were HLA-A2, -A9, -B0, -B35, -B17, -Cw4, and -DR5. In the inhabitants of Tuva, the frequency of the antigens HLA-A1, -A9, -B17, -Cw2, and -Cw4 was significantly higher than in other Mongoloids, while that of the antigens HLA-A26 and -B22 was lower. This difference was greatest in the case of antigen HLA-B40: it a frequency of 43.4% was detected in it, while in individuals of Mongolian origin, the frequency of this antigen did not exceed 22.5%. Indices of genetic similarity (IGSs), calculated from the gene frequencies of the loci HLA-A, -B, and -Cw, suggested that the Tuvinians were most closely related to Kazakhs (IGS = 0.73), and least related to the Japanese and Uigurs (IGS = 0.66). Our data suggest that Tuvinians significantly differ from the compared populations of Central and Eastern Asia.

Asian People↗
PubMed1997

[Clinical immunogenetics of stomach cancer in Western Siberia].

An immunogenetic examination of 86 cases of stomach cancer established a correlation between predisposition and resistance, on the one hand, and the distribution of allele sets of HLA-genes (classes I and II), on the other. The relationship was found to vary according to sex and age. The most significant relationships with respect to predisposition were identified for HLA-B51 (RR = 19.82) alleles and allele combinations of HLA-DRI-DR7 (RR = 25.52) and HLA-A9-DRI (RR = 33.67). High relative risk of stomach cancer was attributed to the absence of relevant alleles in 91 patients included into the group of comparison. Also, combinations of allele sets were identified in healthy subjects which never occur in stomach cancer patients. The results provide a substantiation for developing an automated system of interpreting HLA-typing data which are instrumental in evaluating the patient's predisposition, resistance and prognosis.

Adult↗
PubMed1995

[Prognostic criteria for the clinical course of systemic lupus erythematosus].

To develop some individual prognostic criteria of SLE clinical course the Wald's analysis of immunogenetic markers (HLA) was used. The obtained summarized diagnostic coefficients allow predicting a subacute or chronic pattern of the disease, the rate of generalization and the most frequent location of the process in certain organs. The constant character of HLA-typing results and the simplicity of the given prognostic tables made the proposed diagnostic method convenient for medical practice.

Acute Disease↗
PubMed1993

[Immunogenetic methods in the prognosis of the efficacy of using a method of transfusing extracorporeally irradiated autologous blood for treating patients with rheumatoid arthritis].

HLA antigens distribution among subgroups of rheumatoid arthritis (RA) patients was compared with reference to the results achieved after the treatment with transfusion of extracorporeally irradiated autologous blood (TEIB). The treatment efficacy was found to be in general 66% and to depend on HLA phenotype, age of the patients, the RA activity. The analysis of associations of clinical significance exhibited by clinical, laboratory and immunogenetic signs made it possible to derive a formula for individual prognostic criterion capable of raising TEIB efficacy to 89%.

Adult↗
PubMed1993

[Frequency distribution of HLA phenotypes, haplotypes and alleles in ethnic groups of Taĭmyr and Chukotka].

HLA typing data of two little populations living in Tajmyr peninsula (Dolgans and Nganasans) and Chukotka peninsula (Chukchas and Chuvantses) were presented. Our data were compared with the International standard distribution of class I HLA antigens in orients and its distribution in orients who live in the Asian part of Russia. Indexes of genetic distribution and genetic likeness were calculated.

Alleles↗
PubMed1990

[Immunogenetic methods for predicting the clinical course of tick-borne encephalitis].

Distribution of HLA antigens, haplotypes and phenotypes of the histocompatibility complex was studied and compared in 110 patients with tick borne encephalitis, living in Novosibirsk. The disease patterns and varieties were many and varied. Distribution of HLA antigens in 140 healthy subjects also living in Novosibirsk served as control. Based on the results of the immunogenetic examination of patients with tick borne encephalitis, the methods were elaborated, enabling one to predict with a high accuracy of probability the development of the feverish, meningeal or focal forms of tick borne encephalitis, one- or two-wave disease variety within the first days of disease. Concurrent analysis of the sex of the person bitten by the virulent tick and combination in one genotype of several allelic forms of the main histocompatibility complex genes allows one to raise appreciably the prognostic significance of the immunogenetic examination and to elaborate high-informative individual diagnostic criteria.

Adolescent↗
PubMed1990

[A clinico-immunogenetic method of prognosis in retrobulbar neuritis as an initial manifestation of multiple sclerosis].

Examination of 166 patients with optic neuritis revealed that 65 of them developed multiple sclerosis (MS) at different times after optic neuritis. The observation period was 9.4 years on the average. Using the clinical, laboratory, immunogenetic methods the clinico-immunogenetic heterogeneity of optic neuritis was discovered, the highly informative specific clinical signs and immunogenetic markers suitable as criteria for predicting different variants of optic neuritis outcomes were defined. Using a heterogeneous successive procedure a method of individual ++pre-nosological prediction of MS in persons with a history of optic neuritis was devised.

Adolescent↗
PubMed1989

[Clinico-immunologic parallels in multiple sclerosis].

HLA antigens were compared in groups of patients with disseminated sclerosis and healthy donors. In remission group as compared with controls, increased were the rates of A9, B7, B13, B35, A0/B17, A1/B7, A9/B7, A3/B35, A11/B7, A11/B8, B5, B7, 15, and in the progredient group--B7, Bw22, B35, A1/B7, A2/B7, A2/B35, A9/B7, B7, 12. These groups were different only in A11/B7 rates. Remitting and progredient course of the disease in women differed in A3 and A10 rates, in men in A2 and A11. In men with remitting course the A2 antigen rate was substantially lower than in any other group. With respect to the disease duration and the degree of patients's invalidization, the groups of benign, malignant, and intermediate course were singled out differing from each other and controls also in their HLA composition.

Adolescent↗
PubMed1989

[Immunologic and immunogenetic heterogeneity of systemic and discoid lupus erythematosus].

The immune and endocrine systems and HLA genotype were subjected to a comparative study in patients with systemic and discoid lupus erythematosus (SLE, DLE). The patients suffering from these diseases were found to differ in a number of the parameters of the immune status including the content in blood serum and supernatant of the cultivated mononuclear cells of the soluble molecules HLA-A, HLA-B and HLA-DR. The degree of the SLE and DLE association with the genes and haplotypes of class I HLA complex was different as was the character of the association of HLA-A and HLA-B specificities with the activity of the immune system cells and with hydrocortisone content in plasma. The common immunogenetic syndrome characteristic of SLE and DLE patients has been identified.

Adolescent↗
PubMed1988

[Immunogenetic markers of disseminated sclerosis in western Siberia].

The contents of class 1 HLA antigens was compared in patients with disseminated sclerosis, their first-grade relatives and healthy donors. Patients, as compared to healthy persons, had higher occurrence rate of A1, A9, B7, A0/B0, A9/B7, A1/B7, A1/B12, A2/B7, B7, 27, B5, 0, B7, 12, B7, 15, B5, 7, and lower A28, B13, Bw22, B35, 40, B7, 35, A2, w19, A0/B35, A0/B13, A2/B15, A3/B35. In male patients, as compared to female patients, B40 and A1/B15 were more frequent, and B12 less frequent. The subgroup of patients with the diseases onset before 20 years considerably differed from other patients in their rates of A1, A1, 2, A1w19, A1/B0 increased and A3 and A9/B17 decreased. Compared to donor group, the patients' relatives had differences similar to those between patients and relatives. High relative risk values were characteristic of some of the above associations.

Adult↗
PubMed1986

[Changes in the levels of soluble HLA antigens and their light chains (beta 2 microglobulin) in rheumatoid arthritis and systemic lupus erythematosus].

An increase in the level of soluble HLA-A and B antigens in the blood serum of patients with rheumatoid arthritis and systemic lupus erythematosus was observed using IKO-1 monoclonal antibodies and polyspecific alloantisera. This increase was accompanied by the elevation of the concentration of beta 2-microglobulin (the light chain of the molecules of HLA-antigens of the 1st class). A degree of the concentration of soluble HLA-antigens and beta 2-microglobulin depended on a degree of disease activity, a variant of a clinical course and the presence of visceral involvement.

Adolescent↗