PubMed Health⌕ Search

Biomedical subjects

V F Uchaĭkin

Publications and source records attributed to V F Uchaĭkin.

At least 19 recordsLinked to original sources
PubMed2002

[Treatment and outcome of chronic hepatitis B in children].

225 children at the age from 6 months to 15 years with chronic hepatitis type B (CHB) were under observation. In addition to clinical biochemical evaluation and morphological recording, there also was the serologic monitoring of the pathologic process condition by means of determination of hepatitis type B and other hepatitis viruses markers. The patients were observed during 1-10 years. It was found that almost all of the patients, with the exception of 3 children (1.3%), had no acute onset of the disease. According to the morphological study data, changes in the liver varied from minimal to apparent activity, up to the formation of hepatocirrhosis in single cases. The clinical presentation of CHB in children included mainly the enlargement and induration of the liver, enlargement of the spleen and anhepatic signs (capillaritis and telangiectasia). After 4 years from the onset of CHB stable and prolonged remission was formed in most of the patients (64.6%); in 35.4% of cases clinical biochemical activity of the disease remained for a longer period of time (5-10 years or longer). The gradual cessation of the disease activity correlates with seroconversion of HBeAg on anti-Hbe. Children with the continuous pathologic process in the liver have HBV DNA in their blood. The main outcome of CHB in children is a prolonged remission with permanent HBs-antigenemia in 89% of cases. The recovery was recorded in 9.68% of cases (disappearance of HbsAg and acquisition of anti-HBs). Hepatocirrhosis was formed in 3 children (1.32%).

Adolescent↗
PubMed2000

[Hepatoprotective action of phosphogliv in surgery of patients with chronic calculous cholecystitis].

32 patients with chronic calculous cholecystitis were treated by a new preparation. Phosphogliv (on the base of polyunsaturated phospholipids)--5 days before planned surgery and 5 days after. The increase of alanine and asparagine aminotransferases activities and of bilirubin concentration (2-2.5 fold) was observed in all the patients, cirespective of the drug treatment. However, the essential difference between treated and untreated patients was revealed in the course of post-operative period. In the control group asparagine aminotransferase activity and bilirubin level remained high, and alanine aminotransferases activity even more increased. In contrast, both two aminotransferases activities and bilirubin level fell substantially in Phosphogliv group, that may show more active liver regeneration after surgery. Besides, in this group operation did not result even in short-time changes of plasma protein fractions ratios--opposite to control. It may testify on some protective action of Phosphogliv on liver protein-synthesis system. The observed action of new phospholipid preparation Phosphogliv, together with the absence of side effects, allows to recommend it as an adjuvant in the surgery of patients with chronic calculous cholecystitis. Besides, the above results broaden usage field of polyunsaturated phosphatidylcholine as cell membranes repair agent: it appears to be effective not only for liver diseases treatment, but also for soonest overcome of post-surgery liver changes.

Bilirubin↗
PubMed2000

[New domestic phospholipid preparation "Fosfogliv" as an effective treatment for patients with acute viral hepatitis].

Patients with acute viral hepatitis B, A and mixed hepatitis B + C were treated in two independent clinics with phosphogliv--a new hepatoprotective drug based on polyunsaturated phosphatidylcholine and glycyrrhizic acid salt. Phosphogliv removed some symptoms of intoxication (nausea, weakness, jaundice, etc.) quicker than basic therapy. Among biochemical hepatitis markers, serum bilirubin level was most responsive to phosphogliv. Standard therapy decreases bilirubin by 30% on the average for 5 days, phosphogliv reduces bilirubin for one more week to half those values observed in control patients. At that point low aminotransferase activities were seen in phosphogliv treated patients. No side effects were seen. The new hepatoprotector phosphogliv which repairs biomembranes represents drugs of new generation compared to phospholipid drug essential.

Acute Disease↗
PubMed1992

[Prevalence of hepatitis B in the focus of HIV infection].

Highly sensitive up-to-date research methods (enzyme immunoassay) for HbsAg and antibodies against HBsAg and HBcAg were employed to examine 565 adults and children living in the Kalmuck++ ASSR (Elista and adjacent regions), where in 1988-1989 cases of HIV-infection were recorded. Markers of HBV-infection were detected with a high enough frequency in the control group of children (15.2%). The prevalence of the infection in the adult population was at an intermediate level (38.9%). The high infectivity with HBV-infection was recorded among children who had been hospitalized before (for different diseases including chronic ones), among women who had undergone laboratory studies because of the diagnosis of HIV-infection in their children; among adult patients suffering from tuberculosis of morons from a closed boarding school. The highest frequency of HBV-infection marker demonstration was found in HIV-infected children (70%). The data obtained point to the necessity of vaccination against viral hepatitis B in risk groups (children and adults) and in the newborn as well as of raising the efficacy of preventing measures against infections transmitted via blood.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[Clinico-pathogenetic role of hormones of the pituitary-adrenal system and somatotropin in the development of immunosuppression in chronic hepatitis B and delta infection in children and the approach to its correction].

The basal level of secretion of hypophyseal (ACTH, STH) and peripheral glucocorticoid (cortisol, corticosterone) hormones as related to the immune status (lymphocyte subpopulations, serum immunoglobulins, circulating immune complexes, macrophagal component) and specific marker profiles of viruses B and delta was measured in 142 children with different forms of chronic virus hepatitis B and delta (D). The patients with chronic persistent hepatitis was characterized by the "cortisol" type response of stressor adaptation hormones in parallel with the genetically determined weak immune response, demanding no correction. The patients with chronic active hepatitis B and D demonstrated the "central" type of hormonal response with a primary increase in the content of ACTH and CTH and a moderate rise of the cortisol level, which correlated with pronounced secondary immunodeficiency of the T cell and macrophagal components of immune response. In the patients with chronic virus hepatitis B and D, the hormonal profile, as liver cirrhosis develops, is characterized by an increase in corticosterone and blood somatotropin and by a relatively low cortisol content. This reflects depletion of the mechanisms of adaptation and correlates with deep insufficiency of all the three components of immune response. The use of human leukocytic interferon and T-activin exert a well-defined effect on hormonal adaptation of immune response, promotes completion of HB-virus infection replication and the onset of a stable remission.

Adjuvants, Immunologic↗
PubMed1991

[Current etiological structure of acute viral hepatitis in children].

The etiological structure of viral hepatitides (VH) was defined in 345 children admitted to the clinic during one year with a diagnosis of acute viral hepatitis. It was established on the basis of clinico-laboratory studies and identification of serological markers of viral hepatitides A, B and delta. It has been demonstrated that in the structure of viral hepatitides in children living in Moscow, VHA accounts for 83.1%, acute VHB for 11.1%, HBV and HDV coinfection for 2.6%, and VH non A non B for 1.7%. In children of the first year of life, acute hepatitis was etiologically related to HBV-infection or to HBV and HDV coinfection. In a negligible part of the patients, VHA was diagnosed in the presence of chronic HBV-infection (1.2%) or exacerbation of chronic hepatitis B (0.3%). These data should be taken into consideration in planning and carrying out diagnostic, treatment and prophylactic measures aimed at solving VH problem in childhood.

Acute Disease↗
PubMed1990

[State of cellular and humoral immunity in children infected with human immunodeficiency virus].

Cellular and humoral immunity was examined in 32 children infected with human immunodeficiency virus, living in the Kalmyk ASSR. For comparison purposes, examinations were also made of 6 healthy children and 11 children afflicted with different diseases, living in the same republic. A dramatic lowering of the absolute content of T helper lymphocytes, an appreciable decrease of the T helper/T suppressor ratio associated with the high level of circulating immune complexes were revealed. In children infected with human immunodeficiency virus, grave immunodepression occurred at the early stages of the pathological process. The authors describe the totality of alterations in the immunological parameters, which may give rise to the generalized forms of opportunistic diseases in children infected with human immunodeficiency virus.

Adolescent↗
PubMed1989

[Viral hepatitis in children].

The etiological structure of viral hepatitides in childhood is considered in the paper from current positions. The latest achievements in the field of the immunopathogenesis of acute, fulminant and chronic forms of the diseases are described. The etiotropic and immunocorrective therapy of chronic hepatitis B is pathogenetically grounded. The prospects of investigations of the problem are shown. The facts of the efficiency of the treatment of chronic hepatitis B with different drugs, human leukocytic interferon, BCG vaccine and T-activin, are provided.

Child↗