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Biomedical subjects

V Farr

Publications and source records attributed to V Farr.

18 recordsLinked to original sources
PubMed1988

Pregnancy outcome in mothers who develop Kell antibodies.

This is a review of the obstetric histories of women with Kell antibodies who delivered between 1964 and 1983. The majority of women with Anti-Kell in their sera have Kell negative husbands and have been sensitised by blood transfusion. In only six mothers was antibody formation the result of isoimmunisation and all cases where the baby was known to be Kell positive ended in fetal death. Amniocentesis is not helpful in managing these cases, and at times might be misleading, so that other techniques, such as ultrasound, might be more helpful. A review of the literature confirms that Kell isoimmunisation is rare, but that when it does occur the outlook for the baby is poor.

Blood Group Antigens↗
PubMed1969

Effect of intra-amniotic oestriol sulphate on uterine contractions.

The effects of oestriol sulphate on myometrial activity in a group of young primigravidae, who were at 41 or more weeks' gestation, are compared with those of a placebo in a double-blind trial. Both compounds were administered over a period of six hours directly into the uterine cavity following artificial rupture of membranes. Intra-amniotic pressure recordings demonstrated a peak in the mean intensity in uterine contractions in the oestriol-treated and placebo-treated groups at six and four hours, respectively. The length of labour tended to be shorter in those patients having greater uterine activity.

Adolescent↗
PubMedDate not supplied

Maternal serum alpha fetoprotein in monozygotic and dizygotic twin pregnancies.

Maternal serum alpha-fetoprotein (MSAFP) values in the second trimester have been related to pregnancy outcome for 100 normal twin pairs, 42 monozygous (MZ) and 58 dizygous (DZ), liveborn after 28 weeks gestation. The median MSAFP value was 1.9 multiples of the median value (MOM) for uncomplicated singleton pregnancies. Both very low and very high MSAFP values were associated with twins of low birthweight. MSAFP values were higher in MZ than DZ twin pregnancies particularly those with dizygotes of like-sex. This effect was even more marked when only dichorionic like-sex twin pairs were compared.

Birth Weight↗
PubMedDate not supplied

The impact of maternal serum alpha fetoprotein screening on open neural tube defect births in north-east Scotland.

Over the three years period 1980-1982, 18 256 pregnancies in the Grampian Region of N-E Scotland including the islands of Orkney and Shetland were screened for raised levels of maternal serum alpha fetoprotein (MSAFP) in the second trimester. Thirty six cases of fetal open neural tube defect in singletons were detected (18 anencephaly and 18 spina bifida). Four additional cases of open spina bifida were associated with normal MSAFP levels although two of these were detected by amniotic fluid AFP measurement when amniocentesis was carried out because of previous NTD history. A further three cases of open spina bifida and two of anencephaly occurred in unscreened pregnancies. The MSAFP screening programme alone was thus instrumental in reducing the birth incidence of open neural tube defects by 36 out of 45 cases (80 per cent) in singletons.

Amniocentesis↗