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V Ferrari

Publications and source records attributed to V Ferrari.

At least 55 records · Page 3Linked to original sources
PubMed1987

Temperature dependence of the acid dissociation constants of chloroquine.

The pKa values of the conjugate acids of the antimalarial drug chloroquine were determined at various temperatures using fluorescence spectrophotometry and nonlinear regression in the data analysis. Both pKa values decreased by approximately one unit with increasing temperature over the range 0-37 degrees C with enthalpy changes of 46 and 49 kJ X mol-1. The ionization of chloroquine was found to be mainly controlled by the change in enthalpy. The chloroquine monocation was shown to be almost exclusively in the alkylamino protonated form at all temperatures studied.

Chloroquine↗
PubMed1986

The pH-dependence of chloroquine uptake by phosphatidylcholine vesicles.

The pH-dependence of chloroquine uptake by phosphatidylcholine bilayered vesicles was investigated to examine the relative affinity of ionized and un-ionized chloroquine species to membrane bilayers. The results suggest that the neutral species and monocation are taken up by the bilayers but only the un-ionized species interacts significantly with the hydrocarbon interior.

Chloroquine↗
PubMed1986

A survey of 311 patients receiving ibopamine mainly during hospital treatment for severe congestive heart failure.

From a monitored release of ibopamine, the 3,4-diisobutyryl ester of N-methyldopamine, during the early Italian marketing of the drug a collection of 311 individual cases was formed. The cases were reported by 168 cardiologist-practitioners, self-selected for having a therapeutic interest in the inotropic properties of ibopamine and in trying it out in patients with mostly severe, refractory congestive heart failure (CHF). Most patients were monitored during a hospital admission for worsened CHF. After clinical reassessment and other drugs' adjustment, ibopamine was added and the patient followed-up for 20 days in hospital with regular recording of scored signs and symptoms, arterial pressure, heart rate, body weight, and any clinical event--adverse or beneficial. Concomitant drugs were also recorded. Global assessment of efficacy was mostly positive, with "ineffective" rates of only 15.9% (doctors) and 14.2% (patients). In the absence of a control group, it is impossible to determine to what extent the foregoing was really due to ibopamine or to the rest of the therapeutic policy. However, the fact that most of the severe cases had been refractory to prior treatment, and that they individually carried a grave prognosis on admission, do seem to point to real ibopamine-related benefit. The high rate of symptomatic benefit perceived by the patients would also seem likely to be drug-related. Heart rate after the ibopamine-including regimen was significantly lower than before. Systolic and diastolic arterial pressures also tended to decrease, especially in CHF of hypertensive etiology.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗