Biomedical subjects
Publications and source records attributed to V Florea-Ciocoiu.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In a group of 38 epileptics, 13.1 % had alterations of serum lipids before administration of antiepileptic therapy. An inverse relation was found between the level of serum lipids and that of drug concentration : on minimal daily doses, phenobarbital attained disproportionally high concentrations in a patient with hypocholesterolemia + hypotriglyceridemia, while on large daily doses phenobarbital and/or diphenylhydantoin attained low concentrations in the patients with hypercholesterolemia alone or accompanied by hypertriglyceridemia.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A polygraphic study on resistance to habituation of the somatic, autonomic and EEG components of the orienting reaction elicited by a repetitive auditory stimulus was performed in 66 epileptics with therapy-resistant partial seizures (TRPS) and in 135 matched subjects in two control groups. The study showed a significantly higher resistance to habituation of the orienting reaction in epileptics with TRPS vs. the normal subjects of the control group I. A significantly higher resistance to habituation was also noted vs. the epileptics with therapy-controlled partial seizures of control group II. The correlational analysis of data showed that the severity of these habituation disturbances in epileptics with TRPS depended on the patients' age, type of electroclinical seizures, pretrial seizure frequency, type of resting EEG, administered treatment (no. of administered antiepileptic drugs/patient), daily dose, as well as on the serum level of these drugs. The multivariate regression analysis showed that the most significant predictive variables for the habituation disturbances were the pretrial seizure frequency, type of electroclinical seizures, daily dose of administered antiepileptic drugs and their serum level. The data also evidenced that the antiepileptic treatment improves the interictal habituation disturbances, the effect being more marked as the treatment was more sustained. The above-mentioned habituation changes in epileptics with TRPS should be ascribed to some disturbances in nervous excitability.
A polygraphic study of the somatic, autonomic and EEG components of the orienting reaction elicited by an auditory stimulus was performed in 66 epileptics with therapy-resistant partial seizures (TRPS) and in 135 matched subjects in two control groups. The study showed a significant interictal hyperresponsivity in epileptics with TRPS vs. the normal subjects of control group I, which consisted in a marked increase of the intensity of the orienting reaction components. This hyperresponsivity was also more marked than that noted in epileptics with therapy-controlled partial seizures of control group II. The correlational analysis of data showed that the severity of these responsiveness disturbances in epileptics with TRPS depended on the patients' age, type of electroclinical seizures, pretrial seizure frequency, type of resting EEG, administered treatment (no. of administered antiepileptic drugs/patient), daily dose, as well as on the serum level of these drugs. The multivariate regression analysis showed that the most significant predictive variables for the responsiveness disturbances were the pretrial seizure frequency, type of electroclinical seizures, daily dose of administered antiepileptic drugs and their serum level. The data also evidenced that the antiepileptic treatment improves the interictal responsiveness disturbances, the effect being the more marked as the treatment was more sustained. The above-mentioned responsiveness changes in epileptics with TRPS should be ascribed to some disturbances in nervous excitability.
A computerized EEG topographic analysis (CETA) was carried out in 69 epileptics in order to evaluate the diagnostic value of such an investigation compared to that of the routine interictal EEG. The spectral frequency analysis of the bioelectrical activity in these patients was accomplished both by the fast Fourier transform and by the autoregression method. The obtained data were used for the spatial analysis of the electrical activity which was performed both by the interhemispheric coherence technique and by the color-coded topographic mapping in frequency bands. The data analysis showed that in 58 (84.1%) of the epileptics in whom routine EEG evidenced focal interictal bioelectrical abnormalities CETA also showed such abnormalities. However, CETA revealed focal abnormalities also in 8 (72.7%) out of the 11 epileptics in whom interictal EEG was interpreted as normal. The data analysis also showed that CETA was more efficient than EEG in the detection of focal abnormalities in the epilepsy with slow graphic elements, in the partial epilepsy, in the epilepsy with late onset and in the therapy-resistant epilepsy. The focal abnormalities evidenced by CETA were more expanded than those evidenced by routine EEG and the topographic maps indicated the focal involvement of a significant number of frequency bands. Considering the results, the authors make some appreciation regarding the diagnostic values of CETA in epilepsy.