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V Friedberg

Publications and source records attributed to V Friedberg.

17 recordsLinked to original sources
PubMed1989

[Results of 108 exenteration operations in advanced gynecologic cancers].

We can now say that in our opinion exenteration is not an operation that is dangerous to life, if the conditions that will be described below are observed and if the indication is interpreted sufficiently narrowly, although during the first few years results had been moderate indeed. Exenteration has since developed so positively that it is now increasingly possible to consider the aspect of preserving the function of the adjacent organs, so that the disadvantages resulting for the patient's own body image and her self-concept and self-appraisal are now relatively acceptable compared to what had been possible previously. Indication for exenteration results from the situation, the ideas and the motivation of the patient, mainly, however, against the background of the characteristic features of the operation described here. Today we can say that even these extensive operations are firmly established in gynaecological oncology if there are extended carcinomas and recurring carcinomas. Hence, I believe it is advisable--at least in central recurring carcinomas--to refer such patients to competent surgical oncological centres before attempting to irradiate (or to irradiate again) the recurring tumour.

Colostomy↗
PubMed1989

[A new experimental method for the treatment of pelvic wall recurrencies of gynecological malignancies].

Pelvic side wall recurrences of gynecological malignancies subsequent to primary or adjuvant radiation therapy have a bad prognosis, although in almost half of the cases, distant metastases are not present at the time of diagnosis of the local tumor progression. A radical operative resection of the pelvic wall recurrence is rarely possible and a second conventional percutaneous or intracavitary irradiation with a tumoricidal dose is no longer feasible, because of the limited radiation tolerance of the surrounding pelvic tissue. The different forms of chemotherapy applied at present are not curative. Based on considerations of tumor and radiation biology, we propose a new experimental treatment mode after subtotal tumor resection. Intraoperatively, guiding tubes for afterloading HDR brachytherapy are fixed equidistantly on the tumor bed resp. residual tumor at the pelvic side wall. Coverage of this area by a rectus abdominis muscle flap or de-epithelialized myocutaneous flap improves fixation and creates a protective distance between radiosensitive pelvic structures and the radioactive source inserted postoperatively. In addition, improved vascularization by the flap might reduce the potential of hypoxia induced radioresistance of the residual tumor. Under these circumstances it appears possible, to deliver a second tumoricidal radiation dose of a small volume to a precisely defined area of the pelvic side wall.

Abdominal Muscles↗
PubMed1979

[Brucellosis].

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Brucellosis↗
PubMed1979

Investigations of gestation-induced metabolic changes in the rat liver. I. Glycogen metabolism.

The activities of alpha-glucan-phosphorylase and phosphoglucomutase and the concentration of glycogen were measured in the liver of pregnant and non-pregnant rats. There were no significant differences between normal non-pregnant and pregnant animals nor was there any change of enzyme activities during pregnancy. Our results lend support to the idea that glycogen metabolism is not changed during normal pregnancy.

Animals↗