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Biomedical subjects

V Frydl

Publications and source records attributed to V Frydl.

3 recordsLinked to original sources
PubMed1987

Cerebral blood vessel changes in old people.

We give an electron microscopic description of vascular convulates, which occur along with normal brain aging. They consist of up to 10 vessels which are surrounded by a common perivascular space. We can make clear that the convolutes consist exclusively of normal arterioles. Each single vessel shows endothelial cells without pores. The media is mostly composed of a single layer of smooth muscle cells which are surrounded by adventitial cells or their processes. The adventitial cells show a high amount of lipid inclusions. From microangiographic research it is obvious that the absolute increase in length of the vessels is the main factor in the genesis of vascular convolutes. According to experimental animal studies it seems likely that recurrent hypoxic conditions lead to a considerable increase in length in the cerebral arterioles in old people.

Adult↗
PubMed1985

Glycogen accumulation of the aging human brain.

We describe light- and electron-microscopically a new type of intracytoplasmatic inclusions within cell processes of the cerebral cortex and the underlying white matter. These structures measure 5-50 micron in diameter and consist almost exclusively of densely packed alpha- or beta-glycogen granules, which never occur together in any single structure. Within their periphery, electron-dense amorphous spots and cell organelles, especially mitochondria, were seen. No membrane-bound glycogen was observed. We propose to call them granular glycogen bodies. They occur in 4 of 7 examined postmortem specimens of the cerebral cortex of people older than 60 years of age. They were not found in 4 younger controls aged 26-48. Their appearance may reflect a distinct turnover disorder of carbohydrate metabolism, which becomes manifest under diverse pathologic conditions and in the normal aging process.

Adult↗