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Biomedical subjects

V Fuchs

Publications and source records attributed to V Fuchs.

At least 73 records · Page 4Linked to original sources
PubMed1980

Development of dependence on levorphanol in rats by oral intake of the drug -- the influence of taste on drinking behaviour in rats physically dependent on levorphanol.

Oral administration of levorphanol solution induces physical dependence in rats within a few days, as demonstrated by abstinence symptoms such as loss of body weight, sensitivity to touch and inversion of locomotor activity after withdrawal from the drug. In order to examine whether the physically dependent rats show an active drug-seeking behaviour they were given successively free choice between sweetened levorphanol solution (LSa) and two alternative drinking liquids -- sweetened tap water (WSa) and unadulterated water (W). In the case of LSa and W the rats chose LSa, but they preferred WSa to LSa. Another group of rats made dependent on unsweetened levorphanol solution (L) had the choice between L and W. They rejected L immediately.

Animals↗
PubMed1980

The influence of p-chlorophenylalanine on different morphine effects.

p-Chlorophenylalanine (p-CPA) reduces brain 5-hydroxytryptamine (5-HT) without altering the dopamine and norepinephrine content. Morphine does not influence the 5-HT level, but partly reverses the depletion of 5-HT by p-CPA. Morphine analgesia and toxicity are not affected by p-CPA treatment. p-CPA also has no effect on acute morphine hypothermia, but after chronic treatment of 5-HT-deficient mice the dose--response curve is no longer parallel, which suggests that another mode of morphine hypothermia occurs. p-CPA diminishes morphine-induced running after acute as well as after chronic morphine administration. p-CPA treatment reduces the sensitivity to the naloxone-precipitated withdrawal reaction, but does not affect the development of physical dependence.

Analgesia↗
PubMed1980

[Use of solubilization for the preparation of samples for determination of heavy metals in biological materials using atomic absorption spectrophotometry].

Solubilisation was tested for its suitability to prepare organic samples for metal determination. Flameless atomic-absorption spectrophotometry was used as test method. Copper, manganese, zinc, and chromium levels were determined from various organ systems of Wistar rat, in response to "normal" feeding of pelletised standard feed. A comparison between experimentally established concentrations, on the one hand, and literature data, on the other, suggested that solubilisation was applicable with good success to the preparation of samples from which to determine reliable values, in ppm and ppb, of the above elements.

Animal Feed↗
PubMed1980

[Control of trace elements in the rat using the heavy metal antidote "Unithiol" (sodium-2,3- dimercaptopropane sulfonate)].

The trace element balance in laboratory rats was found to be affected by somewhat lasting application of "Unitiol". Unambiguous decline of manganese, copper, and zinc concentrations was recorded from blood and liver. Complex fixation of copper was stronger than that of the other elements tested. No dose-dependent changes were observed with the experimental arrangement described. The chromium levels in all examined organs were affected but slightly or not at all. The proposal is made that long-term therapeutic use of chelate formers should be accompanied by properly balanced application of essential trace elements.

Animals↗