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Biomedical subjects

V G Baranov

Publications and source records attributed to V G Baranov.

At least 19 recordsLinked to original sources
PubMed1988

[Development of diabetes mellitus in the progeny of 6 generations of female rats with alloxan diabetes].

The development of diabetes mellitus has been studied in six progeny generations of female Wistar rats with alloxan diabetes coupled with normal males. An increased incidence of diabetes and its higher degree have been observed in younger generations studied. A correlation has been established between the frequency of diabetic type of glucose tolerance and hypoglycemia in rats of the first generation during the first month of their postnatal life, and the incidence of diabetes in the progeny of mother rats from the older generations.

Animals↗
PubMed1977

[Effect of monoamine levels on gonadotropin releasing hormone concentration in the hypothalamus, pituitary gonadotropic fuction and ovarian ovulatory and hormonal function].

Daily administration of 0.25 mg reserpine during 14 days reduces the noradrenaline and dopamine level in the hypothalamus by 21--47 per cent and the LH level in the blood. The amount of Gn-RH in the supra-and retrochiasmatic portions of the hypothalamus is significantly increased thereby indicating an inhibition of the RH release into the blood of portal vein. The same course of 0.5--0.75 mg reserpine reduces the level of catecholamines by 51--82 per cent, the Gn-Rh content decreasing in the preoptic, supra-and retrochiasmatic areas along with further decrease of LH level in the blood. This is due, probably, to disturbance of both synthesis and release of Gn-RH. Consequently, the catecholamines activate primarily the release and then the synthesis of Gn-RH. The level of gonadotropins in hypophysis undergoes no essential alterations under the influence of reserpine, the animals develop a constant diestrus, great major yellow bodies appearing in the ovaires while the number of folliculi reduces. The hormonal activity of ovaries at that (secretion of estrogens and progesterone) decreases.

Animals↗
PubMed1976

[Changes in carbohydrate and lipid metabolism and in the structure of the fatty tissue and pancreatic insular apparatus of rats under conditions of prolonged overeating].

Prolonged overfeeding of rats with a highly caloric mixed food led in the majority of the animals to a more intensive increase in body weight and of fat depôt than in control animals given conventional laboratory diet. Rats with adiposity caused by prolonged overfeeding displayed disturbances of carbohydrate and lipid metabolism expressed in elevation of blood sugar level on fasting stomach, a fall of glucose tolerance and of insulin sensitivity, and also in increase of blood insulin activity and of free fatty acids and blood triglycerides on fasting stomach. The number of fat cells in the adipose tissue remained unchanged, but their volume increased. In the animals with adiposity the relative area of the islar tissue of the pancreas and the mass of beta-cells increased significantly; the count of the islar cells in the glandular parenchyma increased as well.

Adipose Tissue↗
PubMed1976

[Role of catecholamines and serotonin in regulating cyclic and tonic secretion of gonadotropic hormones].

In female rats with normal estrous cycle, in the proestrus phase, a significant decrease of the serotonine level was revealed in the anterior and medio-basal parts of the hypothalamus which coincided with ascent of the releasing factor for gonadotropic hormones in the hypothalamus and for gonadotropins in the hypophysis. The dophamine level in the hypothalamic anterior and medio-basal parts changed in different ways attaining during oestrus its maximal values in the anterior and medio-basal parts of the hypothalamus. No regular changes were revealed in noradrenaline content in the course of estrous cycle in any hypothalamic area. For purposes of studying the mechanisms of regulation of the gonadotropins tonic secretion, the same parameters were recorded in androgensterile and ovariectomized rats. Levels of serotonine and noradrenaline revealed no regular connection with changes in the gonadotropins production, while the anterior part of hypothalamis dophamine concentration in the was in reverse proportion to the extent of gonadotropic secretion. Serotonine seemed to participate in regulation of the cyclic but not the tonic secretion of gonadotropins, while dophamine seemed to exert an inhibitory effect on regulation of tonic secretion of gonadotropins.

Animals↗