Biomedical subjects
Publications and source records attributed to V G Borisov.
Five-year experience in the treatment of patients with severe electrotrauma are analysed. They accounted for 3.1% of the total number of patients with burns. The treatment of such patients in of a long duration and expensive. This trauma nonetheless leads to irreversible affection of the organism and disability. The main success is determined by early surgical treatment before the development of pyo-inflammatory processes in the injured tissues.
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Treatment of patients with thermal burns by ointments prepared on a water-soluble base (Dioxidine and Dioxicol) makes it possible to reduce the bacterial dissemination within a short time and prepare the wound for autodermoplasty which, in turn, reduces the danger of the development of infectious complications. In addition to a marked antimicrobial effect, the ointment possess high hydrophobic and hydrophilic properties and do not induce allergic reactions and side effects.
The authors summarize and describe 18-years' experience in the management of patients with burns and determination of the potassium ion content in blood plasma, urine, erythrocytes, and burn exudate. They established that the abnormal potassium content is most hazardous during shock and toxemia and that the changes must be immediately corrected, otherwise complications occur in the course of the burn disease which may prove irreparable and cause death of the patient. The main principles of blood potassium+ control consisted in preventing loss of potassium through the wound and the kidneys and restoring its level by infusion. Early closure of burn wounds is an important moment in the control of potassium blood level disorders]
The article shows that treatment of frostbites in a special medium with controlled temperature and humidity makes the time of treatment shorter and prevents complications characteristic of such a trauma. The main purpose of such exposures of the injured areas is to achieve mummification and to make the operation as early as possible. The mummification of the soft tissues began within 5-8 days after trauma. Chemical necrectomy was possible on the 7th-9th days, followed by autodermoplasty on the 2nd day.
The observation and estimation of results of treatment of 145 patients with burns have shown high efficiency of a biological dressing of porcine skin treated with chemical anticeptics (formaldehyde).
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The pharmacodynamics and efficacy of the new Soviet drug parmidin depending on the state of the coronary reserve are discussed on the basis of the results of observation over 176 patients suffering from chronic ischemic heart disease with affection of the peripheral arteries of the lower extremities. The activity of the drug in patients with atherosclerotic and diabetic affection of the arterial vessels is shown. The pharmacokinetics of parmidin in patients after the administration of a single 1.0 g dose was studied by determining its content in blood and urine 1, 2, 4, 8, 12, and 24 hours later. The effect of parmidin on the blood kinin system in patients with chronic ischemic heart disease was studied.
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