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V G Dev

Publications and source records attributed to V G Dev.

72 records · Page 4Linked to original sources

Chromosome markers in Mus musculus: strain differences in C-banding.

The mitotic chromosomes of several inbred strains of mice and a series of F(1) hybrids have been analyzed by quinacrine staining and further characterized by the centromeric heterochromatin banding (C-banding). Inbred strains had the same amount of C-banding material on homologous chromosomes but showed variation in the amount on different chromosomes. F(1) hybrids showed characteristics of each parent and it appears that the amount of C-banding on each chromosome is a simple inherited polymorphism. In this study 12 different chromosomes could be distinguished by their C-banding, and these can be used as normal chromosome markers.

Animals↗

Assignment of four linkage groups to chromosomes in Mus musculus and a cytogenetic method for locating their centromeric ends.

The mitotic chromosomes in primary cultured cells from mouse embryos of the translocation stocks, T(5;18)26H, T(5;11)7Ca, and T(14;17)264Ca, have been identified by their distinctive fluorescent-banding patterns after staining with quinacrine mustard. In this way, linkage group (LG) V has been assigned to chromosome 2, LGXVIII to chromosome 9, and LGXIV and LGXVII to either of chromosomes 3 or 13. The assignment of LGXI to chromosome 6 has been confirmed. The centromeres of chromosomes 1 (LGXIII), 2 (LGV), 9 (LGXVIII), and 16 (LGIX) have been located at the ends nearest the genes fuzzy (fz), Danforth's short tail (Sd), nervous (nr), and T of their respective linkage groups by a cytogenetic method. The centromere of the X (LGXX) has been tentatively assigned to the end nearest to the scurfy (sf) locus.

Animals↗

Identification of the mouse karyotype by quinacrine fluorescence, and tentative assignment of seven linkage groups.

A karyotype of the mitotic chromosomes of the house mouse has been prepared based upon quinacrine fluorescence patterns. All 19 pairs of autosomes and the X and Y chromosomes have been identified. Examination of the chromosomes of the following translocation stocks, T(11;?)1Ald, T(3;?)6Ca, T(2;9)138Ca, T(2;12)163H, and T(9;13)190Ca, have led to the tentative assignments of autosomal linkage groups (LG) to chromosomes as follows: LGII to chromosome number 10 (or 13), LGIII to 12 or 15, LGIX to 16, LGXI to 6, LGXII to 19 and LGXIII to 1. By definition, LGXX is on the X chromosome.

Animals↗