Biomedical subjects
Publications and source records attributed to V G Koveshnikov.
The epiphyseal cartilage and diaphysis of the tibia have been studied at dehydration and burn trauma. Dehydration produces certain disturbances in growth and formation of the bone, and burn trauma--development of dystrophic changes.
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A feasibility is analyzed of our using a complex of immunological and cytogenetic investigations to assess the impact of adverse factors of antropogenic origination, chemical and radiation ones in particular, on the immune system and genetic apparatus in those persons residing under conditions of a large industrial region. Identified in the above subjects was the presence of different variants of secondary immunological insufficiency, chromosome and chromatid aberrations in liquidators of the effects of the Chornobyl accident, workers of chemicals--, by-product coke plants, and metallurgical works, the degree of the above insufficiency being decided by ecological conditions of residence, presence of occupational hazards, their nature, and duration of exposure.
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Specific features of osteogenesis under a toxic action of pesticide Dipal and antioxidation therapy with tocopherol were studied in experiments in inbred albino rats by the method of autoradiography with 3H-thymidine label. The index of labeled nuclei and intensity of the label in chondroblasts and osteoblasts of the epiphyseal cartilage and periosteum of the middle third of the tibia diaphysis were counted in the light autoradiograms. The method of electron autoradiography was used for the identification of DNA-synthesizing osseous and cartilaginous cells and for studying their ultrastructure. The age-related and topographic activity of the proliferative osteogenic processes, their correlation with the degree of the toxic injury of the organism was established. Dipal, as an osteotropic drug, inhibits proliferative processes in the blast osseous and cartilaginous cells, sharply decreasing the index of labeled nuclei and the label intensity. Correction with tocopherol levels the degree of processes of the inhibition of osteogenesis.
Macro- and microscopic transformations were studied in burned animals skeleton after treatment with alpha-tocopherolum. The antioxidant was found to optimize osteogenesis, disturbed in burn lesion.