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Biomedical subjects

V G Maĭdannik

Publications and source records attributed to V G Maĭdannik.

At least 19 recordsLinked to original sources
PubMed1991

[Problem of pathogenesis of Mycoplasma infection].

It has been shown that irrespective of the primary focus of affliction, M. hominis-induced infection should be regarded as a systemic disease characterized by an immune-mediated inflammation which is contributed to by blood kallikrein-kinin system activation resulting in changes in the coagulative system and fibrinolysis until disseminated intravascular coagulation develops. This allows one to interpret in a new fashion the etiology of some diseases proceeding with signs of vasculitis.

Animals↗
PubMed1990

[A crystallographic method in the diagnosis of kidney diseases].

Structural aspects of copper chloride crystallization of the urine of patients with pyelonephritis and glomerulonephritis were studied by electron microscopy. It was found that admixtures of urea, creatinine, potassium and, possibly, sodium contained in the urine of patients initiate the formation of copper chloride crystals of different sizes, their shape changes, dendritic and spherolithic crystallization occurs. Results may be used as supplementary differential diagnostic signs of glomerulonephritis and pyelonephritis.

Adolescent↗
PubMed1990

[Effect of interferon on the course of experimental E coli-induced pyelonephritis].

The effect of the type I interferon on the development and process of experimental pyelonephritis caused by E. coli was studied on mice weighing 12 to 14 g. Interferon was administered intraperitoneally in a dose of 1000 units on days 3 and 7 of the disease. It was shown that the administration of the type I interferon to the mice with experimental pyelonephritis promoted rapid elimination of bacteria from the kidneys, prevented their penetration to the contralateral (intact) kidney, prevented marked macro- and microscopic damages in the kidneys, lowered the intensity of the inflammatory reaction, and increased the phagocytic activity of neutrophils and the number of the E-rosette-forming lymphocytes in the thymus. The data provided experimental grounding for clinical trials of interferon preparations in treatment of bacterial pyelonephritis.

Adjuvants, Immunologic↗
PubMed1990

[Diagnostic possibilities of a crystallographic method in pyelonephritis in children].

Diagnostic potentialities of the crystallo-optic++ analysis of cupric chloride crystallographs++ were studied in 76 children with pyelonephritis and in 50 children with glomerulonephritis. The structural and morphological characteristics of cupric chloride crystallization under the influence of the urine from children with pyelo- and glomerulonephritis may serve as the additional differential-diagnostic signs of the diseases. The use of raster electron microscopy widens the diagnostic potentialities of the crystallographic method. Different dimensions of the little crystals formed as a result of isomorphic replacement of copper atoms by potassium ions (and, possibly, by sodium ions) and in the presence of urea and creatinine underlie the differences in cupric chloride crystallographs.

Adolescent↗
PubMed1989

[Chemiluminescence of blood and urine in children with pyelonephritis and glomerulonephritis].

It was established during the study of blood serum and urine chemiluminescence in 57 children with pyelonephritis and in 38 children with glomerulonephritis that in the active disease stage, the intensity of overfaint luminescence rises as a result of lipid peroxidation (LPO) activation, accumulation of lipid hydroperoxides and oxygen-containing radicals. Four types of the kinetic curves of urine chemiluminescence were identified. They characterize the correlation between LPO activation and the level of antiradical defence in patients suffering from pyelo- and glomerulonephritis. The measurement of urine chemiluminescence in patients afflicted with pyelonephritis and glomerulonephritis may be one of the criteria for administering drugs possessing antiradical and antioxidant activity and can also be used in the control over the treatment efficacy.

Child↗
PubMed1989

[Immunoenzyme determination of fibrinogen and its degradation products in kidney diseases].

Immunoenzymatic assay (IEA) was used to study the content of fibrinogen and its splitting products (FSP) in patients with pyelonephritis and glomerulonephritis. The active phase of the disease was characterized by a marked increase of the fibrinogen content and FSP in the blood. The changes reflect the process of activation of the blood coagulation system with hypercoagulation phenomena. Immunoenzymatic assay is perspective for the evaluation of the state of hemostasis in renal diseases and for controlling treatment efficacy.

Fibrin Fibrinogen Degradation Products↗
PubMed1989

[Interferon in the modulation of the immune response in pyelonephritis caused by Staphylococci and Pseudomonas aeruginosa].

In experiments on mice the influence of mouse serum interferon, type I, on immune response in pyelonephritis caused by staphylococci and P. aeruginosa has been studied. The immunomodulating action of interferon and its therapeutic effectiveness have been shown to depend on the etiology of the disease. When injected intraperitoneally in a dose of 1,000 ED, interferon produces a pronounced therapeutic effect in pyelonephritis caused by P. aeruginosa and no effect in pyelonephritis of staphylococcal etiology. Type I interferon introduced in the dose used in this investigation has no influence on the killer activity of spleen lymphocytes, enhances the activity of the complement and the production of antibodies, produces a leukopenic effect and, depending on the etiology of pyelonephritis, exerts influence on the activity of dehydrogenases, the number of EAC- and E-rosette-forming cells, the oxidation metabolism of neutrophils and their phagocytic activity.

Animals↗