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Biomedical subjects

V G Rumiantsev

Publications and source records attributed to V G Rumiantsev.

At least 19 recordsLinked to original sources
PubMed2005

[Treatment of the irritable bowel syndrome from the point of conclusive medicine].

For many years the irritable bowel syndrome therapy was based only on an empirical approach. A lot of information has appeared for this period, which allows making a judgment about the efficacy of either of the ways of the functional bowel disorders treatment. A part of them was not approved in the course of clinical testing. At the same time, new high-performance ways of treatment appeared. This article presents an analytical survey of the irritable bowel syndrome pharmacotherapy. It also shows the role of diet, spasmolysants, psychotherapy, tricyclic antidepressants, serotonin reuptake inhibitors, HT3 antagonists and HT4 agonists.

Humans↗
PubMed2004

[Chronic constipations in elderly people].

Chronic constipations in elderly people proved to be an important medical and social problem due to their high prevalence and serious complications caused by the very disease and administration of stimulating laxatives. They include as follows: anorectic incontinence, large intestine obstruction, stercoral ulcers, laxative dependence and bowels toxic affection (Cathartic colon). Morphological and physiological prerequisites of chronic constipation and anorectic incontinence occurrence are examined in this review. Drugs and tactics for monitoring constipations depending on their severity, dominance of transit and evacuation disturbances, occurrence of anorectic incontinence are described. Characteristics of laxatives and intestinal motility regulators, range of side effects as well as experience of their application in elderly patients with functional constipations and irritable bowel syndrome are presented.

Aged↗
PubMed2004

[Clinical-functional and morphological changes in the large intestine in patients with chronic abdominal ischemia].

The article presents a study of clinical variants of ischemic lesions of the large intestine (ILLI) in patients with the chronic abdominal ischemia (CAI) syndrome. There was an examination of 42 patients with putative ILLI, who had a cardiovascular pathology at the background, which led to significant hemodynamic disorders of the blood flow in unpaired visceral branches of the abdominal aorta. The authors performed a complex diagnostics of ILLI including anamnestic and clinical data, laboratory and morphological assessment of the large intestine and vessels providing its blood supply. Based on the data collected, other functional and organic diseases of the large intestine (LI) were excluded. It was revealed that the final result of ILLI differed depending on the ischemia degree--from reversible functional disorders to high-grade organic lesions of the LI. Each clinical variant of ILLI has its own clinical manifestations as well as functional, organic and morphological peculiarities of changes in the LI revealed by a laboratory and histological examination of the LI.

Aged↗
PubMed2004

[Immunosuppressive therapy of inflammatory diseases of the large intestine].

The treatment of ulcerous colitis and Crohn's disease is based on suppression of various components of the immunoinflammatory cascade. In addition to aminosalicylates and glucocorticoids, drugs of primary immunosuppressive action are used for this purpose, which are adopted from clinical oncology and transplantation medicine: azathioprine, 6-mercaptopurine, methotrexate, cyclosporine A, tacrolimus, mycophenolate mofetil, thalidomide. Some of them are used for remission induction in case of hormonal dependence or resistance, while others are applied for its maintenance or at various stages of the inflammatory process course. The presented review discloses problems of clinical pharmacology of immunosuppressive drugs, side effects, results of pilot and clinical studies of ulcerous colitis and Crohn's disease. All this makes it possible to determine their role in the therapy of inflammatory diseases of the bowels.

Colitis, Ulcerative↗
PubMed2003

[Comparative efficacy of mezakol and sulfasalazine in treating chronic relapsing ulcerative colitis].

This research testifies to the fact that it is more preferable to use mesacol than sulfasalazine in treatment of common forms of ulcerative colitis of light and average severity. Mesacol acts faster in arresting inflammations in proximal parts of the larger intestine. One can assume that the pH-dependent release of 5-aminosalicylic acid in these forms of the disease suffers less than the destruction of the diazo link by the anaerobic microflora, due to which a higher concentration of the preparation is formed in the large intestine. Another alternative explanation can be the dose-dependent effect. Thus, 2.4. g of mesacol correspond to 6 g of sulfasalazine. The dose of sulfasalazine was smaller in our study. Mesacol had no advantages over sulfasalazine in treatment of distal colitis, which can and must be treated with rectal introduction of corticosteroids and 5-aminosalicylic acid preparations. Thus, mesacol must be reserved for treatment of patients with common ulcerative colitis of light and average severity in case of intolerance to sulfasalazine or impossibility to increase the preparation dose over 4 g/day. Its efficiency and price make the preparation available for most patients and patient care institutions.

Adult↗
PubMed2002

[Disorders of hemostasis in clinical picture and pathogenesis of inflammatory diseases of the colon (literature review)].

Hemostatic disorders are involved in the pathogenesis of inflammatory large intestine diseases. Both thrombocytes and humoral coagulation factors are involved in this process. An attempt to correct these disorders will allow not only to declare a new approach to the treatment of inflammatory large intestine diseases but also to clarify their role in the occurrence and persistence of an active inflammation during these diseases.

Blood Coagulation Disorders↗
PubMed2002

[Crohn's disease in children].

Crohn's disease is a chronic transmural inflammation that can involve any part of the digestive system, from the oral cavity to the anal canal, being combined with many abenteric manifestations. It can appear at any age. The first description of this disease in a teenager was made in 1834 by B.B. Crohn, and 11 years later a series of observations describing 48 children with this disease was published. The concept of the Crohn's disease as a non-children illness underwent a change with the widening of diagnostic possibilities, wide use of the endoscopic method of diagnostics in pediatric practice, and histological studies of biopsy materials. A steady growth of the frequency of Crohn's disease detections has been recorded since the middle of the 1980s. Morbidity in Great Britain and Sweden doubled reaching 3.1 for 100,000 infants, and in 1993 its spread made up 16.6 for 100,000.

Child↗
PubMed1993

[Comparative characteristics of various types of operations performed in treatment of diffuse colonic polyposis].

Diffuse polyposis of the large intestine characterized by the development of multiple polyps in it and their subsequent malignant degeneration is one of the most severe disease of the gastrointestinal tract. That it must be treated by surgery needs no proof. However, the volume and the character of the surgical intervention on the large intestine is still a debatable problem. The article discusses the experience in the follow-up of 445 patients for periods of 12 months to 30 years after operation for diffuse polyposis. In 228 patients various segments of the large intestine which were free from polyps were not resected. During these follow-up periods malignant tumors developed in the preserved parts of the large intestine in 10.1% patients and intensive growth of polyps was encountered in 3.5% of patients. The frequency of carcinoma development depended significantly less on the length of the follow-up period and much more on the character of affection of the preserved parts of the large intestine with the polyps.

Adolescent↗
PubMed1990

[Prevention of postoperative suppurative complications in patients with inflammatory diseases of the large intestine].

The results of surgical treatment of 103 patients with inflammatory diseases of the colon were analysed. An unfavourable outcome was noted in presence before the operation of the disease complications, and deep metabolic disorders as well. A decrease in the level of serum albumins and hematocrit, increase in the leukocytic count and seromucoid level were prognostically informative. The use of endolymphatic antibiotic therapy in 66 patients operated on with increased risk for the development of complications permitted to reduce lethality after elective operations from 10% (in using the conventional methods of treatment) to 3.3%, after emergency operations--from 75 to 33.3%, respectively. The incidence of postoperative purulent complications has reduced significantly.

Anti-Bacterial Agents↗