Biomedical subjects
Publications and source records attributed to V G Selyatitskaya.
Experiments were performed on two opposite strains of mice differing in the basal blood glucocorticoid concentration in the blood. Infection of animals with C. albicans fungi led to the development of hypocorticism. C57Bl/6 and CBA mice with progressive candidiasis showed a persistent and phasic course of hypocorticism, respectively.
Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.
The distribution of specific mineralocorticoid receptors in rat kidney cells was found to depend on aldosterone concentration. With increasing aldosterone concentrations the number of specific receptors for aldosterone in the cytoplasm decreased and their quantity in the nuclei increased. This was evidently due to their enhanced transport from the cytoplasm to the nuclei. It was found that aldosterone (its complex with the receptor) attached to non-histone proteins of chromatin and that the structural integrity of DNA is needed to provide the binding of this complex to the cell nuclei. The quantity of aldosterone acceptor sites in the kidney cell nuclei remained constant when aldosterone concentrations in the organism changed, and, hence, the functional states of the target organ changed too.
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