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Biomedical subjects

V G Spesivtseva

Publications and source records attributed to V G Spesivtseva.

At least 19 recordsLinked to original sources
PubMed1989

[Early detection of nephroangiopathy in patients with diabetes mellitus and approaches to its correction].

Patients with types I and II diabetes mellitus without the clinical signs of nephroangiopathy were subjected to a comprehensive study of renal function. Using the method for determination of endogenous creatinine clearance (140 patients), radionuclide methods (in 350 patients) and beta-2-microtest (in 130 patients) the impairment of renal filtration function was established in 30.8, 67.6 and in 52% of the patients, respectively. In 16.3% of the patients, there was an impairment of the proximal part of the canaliculi. The determination of proteinuria selectivity in polyacrylamide gel revealed latent proteinuria in 70% of the patients and enabled one to specify the spectrum of uroproteins. The informative value of the methods suggested was supported by the results of morphologic studies of biopsy specimens of the kidneys and skin. The importance of the specification of the preclinical stage of diabetic nephroangiopathy was determined by the possibility of the reverse development of the pathological alterations at the given stage. The authors describe the experience gained with the correction of functional disorders by means of programmed administration of insulin using the apparatus Biostator, application of diamicron and angioprotectors.

Creatine↗
PubMed1987

[Use of high-purity insulins in the treatment of patients with diabetes mellitus].

A total of 43 patients aged 16-62 with moderately severe and severe type I diabetes mellitus of 2-27 years duration were observed. The patients were admitted to hospital with decompensation of metabolic processes. In order to achieve compensation monocomponent insulins were administered in an individual dose depending on the levels of glycemia and glucosuria and a scheme of drug administration (2 times continuously, i.v. using the Biostator apparatus). The duration of therapy was 4 months. A hypoglycemic effect in relation to immunological and hemorheological indices was assessed. A hypoglycemic effect was noted in all the patients. A positive effect of high-purity insulins on immunological and hemorheological indices was revealed. These insulins can be used for prevention of diabetic angiopathies.

Adolescent↗
PubMed1985

[Clinico-morphological characteristics of diabetic nephroangiopathy in insulin-dependent diabetes mellitus].

The clinicofunctional characteristics of the kidneys were estimated, biopsy of the kidney and skin with an immunohistochemical study was performed and some immunity values considered in 17 patients with type I diabetes mellitus. The study was performed with respect to the degree of expression of the clinical signs of nephropathy including the preclinical stage, too. Three types of morphological changes in the kidney and skin were singled out. Initial tubuloglomerular disorders occurred at the preclinical stage of nephroangiopathy. The nature of changes in the skin coincided mostly with changes in the kidney lagging behind in some cases. The results confirmed the leading role of metabolic derangements in the genesis of microangiopathies and a necessity of a good compensation of diabetes for its prevention. The immunohistochemical and immunological findings did not make it possible to exclude the immune mechanisms in the development of diabetic nephroangiopathy.

Adolescent↗