[Pathogenesis of ischemic disorders of the cerebral circulation in arterial hypertension].
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Biomedical subjects
Publications and source records attributed to V G Vysotskaia.
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Eighty males with various stages of essential hypertension and 20 practically healthy individuals were included in this study designed to examine their platelet aggregation properties and blood viscosity and to determine the levels of prostaglandins E and F. On the basis of the results obtained, new aspects of the pathogenesis of essential hypertension were ascertained. The pathophysiologic mechanisms underlying the development of hypertensive crises and other complications of hypertension are reviewed in the light of possible PG involvement.
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The authors present data on examining platelet and erythrocyte aggregation, blood viscosity, and platelet adhesion index in 96 patients with initial signs of cerebral circulation insufficiency, 45 patients with transient disturbances of the cerebral circulation, and in 40 patients with cerebral infarctions due to atherosclerosis and its combination with arterial hypertension. On the basis of the data obtained the importance of the changes of the blood rheological properties in the pathogenesis of the atherosclerotic cerebrovascular disorders (of various gravity) was specified, a dependence of these changes on the acuity of the manifestations of the transient cerebral circulation disturbances or cerebral infarction, and on the use of medicines was disclosed, and recommendations on administering antiaggregants and drugs lowering the blood viscosity and erythrocyte aggregation are given.
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The morphological changes in the walls of 40 arterial microanastomoses were studied in experiments. The initial signs of endothelization appear in 3 days and the process ends by the 9th-12th day. The tissue reaction to the different suture material is of the same type and its degree is not linked with the type of synthetic thread used. Minimum injury inflicted to the intima and the other coats of the vascular wall and pre- and postoperative use of acetylsalicylic acid are measures preventing occlusion and stenosis of the anastomosis.