EFFECTS OF ROUS SARCOMA VIRUS ON CHICKEN-EMBRYO LIMB BUDS GRAFTED ONTO THE CHORIOALLANTOIC MEMBRANE.
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Biomedical subjects
Publications and source records attributed to V GROUPE.
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Homologous and isologous transfers of Rous sarcoma cells in turkeys indicate that growth of the implanted cells contributes little, if at all, to the formation of these neoplasms. Infection of normal host cells by virus appears to be, at least in this species, the major factor in the induction and progressive growth of Rous sarcomas.
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Virus-neutralizing factors in tumor extracts and sera, age of the tumor, and the infecting dose of virus are important factors contributing to the infective titer of tumor tissue. Tumors produced with small amounts of virus may contain no demonstrable infective virus, and detectable inhibitory factors may or may not be present in tumor extracts or sera.
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