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Biomedical subjects

V Galea

Publications and source records attributed to V Galea.

13 recordsLinked to original sources
PubMed1997

Loss of twitch torque following muscle compression.

With the elbow flexed, compression of the human biceps brachii has been found to reduce twitch torque, with an approximately linear relationship being observed between the loss of torque and the applied pressure (up to 45 kPa). The decline in torque could no longer be demonstrated when the biceps muscle was stretched, by extending the elbow from a flexed position. The loss of torque in the flexed position appeared to be due to an inability of muscle sarcomeres to bulge sufficiently to take up the series elasticity at the fiber ends.

Adult↗
PubMed1996

Potentiation and depression of the M wave in human biceps brachii.

1. The effects of repeated excitation on the compound action potential, or M wave, of mammalian muscle fibres have been investigated in the human biceps brachii. 2. During continuous indirect stimulation at 10 and 20 Hz the mean voltage-time area of the M wave doubled within the first minute, while the mean peak-to-peak amplitude increased by approximately half. The enlargement of the M wave was sustained during stimulation at 10 Hz but not at 20 Hz. Stimulation at 3 Hz caused a small increase which was significant for M wave amplitude only. 3. When the 20 Hz stimulation was performed under ischaemic conditions, the M wave first enlarged and then gradually declined. After 20 Hz stimulation was discontinued, the M wave increased in size; in the ischaemic experiments the release of the cuff produced a further, rapid augmentation. In both the ischaemic and non-ischaemic experiments, the amplitudes and areas of the M waves during the recovery period became significantly larger than the resting values (range, 15-60% at the endplate zone). 4. The mean muscle fibre impulse conduction velocity decreased to less than half the resting value during 20 Hz stimulation, with or without ischaemia, and then increased above the resting value during recovery. 5. On the basis of previous experiments in animals, the augmentation of the M wave was attributed to enhanced electrogenic Na(+)-K+ pumping, and the biceps brachii appeared to be an excellent preparation for studying the time course of this enhancement.

Action Potentials↗
PubMed1996

Changes in motor unit estimates with aging.

Elderly persons usually exhibit some degree of muscle atrophy, together with a reduction in voluntary strength, but there is still argument concerning the nature of the cellular events involved. This issue was reexamined by estimating the numbers and relative sizes of motor units in three limb muscles, using a fully automated system (Galea et al., 1993). In 79 healthy volunteers aged 20-98 years, estimations of motor unit numbers were performed on the thenar, biceps brachii, and extensor digitorum brevis muscles. Motor unit populations were noted to decrease significantly with age in the distal muscles but appeared to remain constant in the biceps. The excitable muscle fiber mass, as reflected in the peak-to-peak amplitude and area of the maximum M-wave, was diminished in all three muscles. Although the area of the average motor unit action potential was not significantly different between groups, the ratio of this potential to the M-wave area increased with increasing age. The results suggest that muscle deterioration in the elderly is due to a combination of changes in the muscle fibers and in their nerve supply and that the extent may differ between proximal and distal muscles.

Action Potentials↗
PubMed1994

Pseudofacilitation: a misleading term.

The possible causes of the transient enlargement of muscle compound action potentials during repetitive stimulation ("pseudofacilitation") are considered. The phenomenon cannot be due to mechanical artefact, while hypersynchronization of the muscle fiber action potentials, the usual explanation, can only make a minor contribution. A more convincing explanation, for which there is now experimental evidence, is that the muscle fibers undergo hyperpolarization, due to the intramuscular release of norepinephrine and consequent stimulation of the electrogenic Na+,K(+)-pump. Defective phosphorylation of the Na+,K(+)-pump is a possible cause of the transient weakness and myotonia in myotonic dystrophy.

Action Potentials↗
PubMed1993

Motor unit populations in healthy and diseased muscles.

The numbers of functioning motor units can be estimated in proximal and distal muscles of human limbs by an electrophysiological technique in which the mean sizes of the motor unit potentials are compared with the maximum M-waves of the same muscles. Although manual methods of estimation have been used successfully in the past, the introduction of automated techniques has brought considerable advantages, including greater objectivity and reduced contamination of the results by "alternation." In healthy subjects, the intrinsic muscles of the hand have approximately 100 motor units each, and the biceps brachii muscle has only slightly more. With advancing age, there is a loss of motor units, which appears to be more pronounced in distal muscles. The motor unit estimating methodology has been found to be of value in the diagnosis and assessment of patients suspected of having muscle denervation. In amyotrophic lateral sclerosis, the mean rate of motor unit loss is swift, whereas in late-onset cases of spinal muscular atrophy, the reduction in the motor unit population does not appear to progress. In only the most rapidly deteriorating cases of post-polio syndrome is it possible to demonstrate further loss of motor units. In all of these denervating disorders, and in peripheral neuropathies, the importance of collateral reinnervation as a compensatory mechanism is emphasized.

Adaptation, Physiological↗
PubMed1991

The numbers and relative sizes of motor units estimated by computer.

A fully automated system is described for estimating the numbers and relative sizes of functioning motor units in proximal and distal muscles of the arm and leg. In this system, a computer controls the motor nerve stimulation, and analyzes the potentials evoked from the muscles; a subprogram searches for instances of "alternation." In 33 healthy volunteers, aged 21 to 56 years, the median-innervated thenar muscles of one hand were tested 2 to 3 times; the mean motor unit estimate was 228 +/- 93 SD. For similar numbers of biceps brachii, extensor digitorum brevis, and vastus medialis muscles, the respective mean values were 113 +/- 40, 131 +/- 45, and 229 +/- 108 units. The reproducibility of the method was such that the overall coefficient of variation, for the normalized results from the 121 muscles studied, was 22%. The reliability of the automated method was doubled if 3 estimates, rather than one, were performed on each muscle. Comparisons of the results obtained by automated and "manual" methods indicated that the computer-derived values tended to be lower by approximately 33%.

Action Potentials↗
PubMed1990

Regional bone mineral measurements.

Total body dual-photon transmission scanning was performed in 9 control persons, 15 athletes and in 5 patients with eating disorders. Total body bone mineral mass was measured, with a reproducibility of 2%; for regional bone mineral mass the reproducibility was 4%. The fraction of total bone mineral in the spines and heads of women is greater than in men. Patients with eating disorders have a smaller fraction of total body mineral in the pelvis than female controls. Weight lifters have a significantly greater mineral mass in the trunk region than other athletes and male controls. These and other differences are consistent with the conclusion that total body dual-photon absorptiometry allows quantitation of the distribution of mineral within the skeleton.

Absorptiometry, Photon↗
PubMed1990

Body composition by photon absorptiometry.

Whole-body dual photon measurements of body composition were made in 9 controls, 15 athletes and 5 patients with eating disorders. Measurements of lean body mass, mineral mass and fat mass were accurate. Lean body mass and fat mass were measured with reliabilities of about 0.8 kg while for total body bone mineral mass, the reliability was about 60 g. Women had a smaller lean body mass and a greater fat mass than men. Women with eating disorders had the same body composition as males. Measurements of body composition by dual photon absorptiometry are safe and reliable.

Absorptiometry, Photon↗