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Biomedical subjects

V García Nieto

Publications and source records attributed to V García Nieto.

At least 19 recordsLinked to original sources
PubMed2005

[Study of renal morphology and function in children with nocturnal enuresis. Relationship with sensitivity or resistance to desmopressin].

BACKGROUND: In the last few years, there have been reports that children with nocturnal enuresis frequently have hypercalciuria. Likewise, children with desmopressin-resistant enuresis have recently been reported to have a higher renal concentration capacity than patients with desmopressin-sensitive enuresis. OBJECTIVES: To study renal function and urinary calcium excretion and to register familial history of enuresis and urolithiasis in a group of children with enuresis, whether responders or nonresponders to desmopressin, followed-up in our hospital. MATERIAL AND METHODS: A cohort of 60 patients (42 boys and 18 girls) who were referred to the hospital because of nocturnal enuresis. RESULTS: Hypercalciuria was detected in 26 children (43.3 %) and hypocitraturia in eight (13.3 %). The frequency of hypercalciuria was higher in desmopressin-resistant patients than in desmopressin-sensitive patients, but this difference was not statistically significant. Sonographic renal morphological anomalies were detected in 11 children (18.3 %). No differences in renal handling of water were detected when the patients were distributed according to the grade of sensitivity to desmopressin. CONCLUSIONS: In our cohort we found a high frequency of hypercalciuria in children with nocturnal enuresis. No differences were observed in maximal urinary osmolality among desmopressin-resistant and desmopressin-sensitive children.

Antidiuretic Agents↗
PubMed2005

[Effectiveness of behavioral intervention in nocturnal enuresis].

BACKGROUND: Nocturnal enuresis is a common, often misunderstood condition that affects millions of children. Although the rate of spontaneous resolution is 15 % per year, treatment is often required for social or psychological reasons. OBJECTIVE: To determine the prevalence of nocturnal enuresis in a primary health care area, how was it diagnosed, which treatments were employed and treatment response. MATERIAL AND METHODS: A retrospective study was performed that included all the medical records of children aged between 6 and 14 years old in a basic health area. RESULTS: Twenty-seven children with a diagnosis of nocturnal enuresis were identified (4.3 %). Among these, 21 were boys (77.7 %) and six were girls (22.3 %). There was a family history of nocturnal enuresis in 15 patients (55.5 %). Nocturnal enuresis was not the reason for consultation in 24 of the 27 patients (88.8 %) but was diagnosed collaterally by anamnesis. All the children had simple primary nocturnal (monosymptomatic) enuresis. Five patients abandoned the treatment (18 %), 15 (55.5 %) recovered with behavioral intervention exclusively, the remaining seven children were treated with desmopressin, which was successful in three of them. The remaining four patients were still receiving treatment when the data were collected. CONCLUSIONS: The prevalence of nocturnal enuresis in this primary health area (4.3 %) is similar that reported in other series. In a high percentage (88.8 %) of patients, nocturnal enuresis was not the reason for consultation but was diagnosed during anamnesis. Behavioral intervention was effective in more than half (55.5 %) of the patients.

Behavior Therapy↗
PubMed2003

[Study of the renal acidification capacity in children diagnosed of idiopathic hypercalciuria].

OBJECTIVE: To study the capacity of renal acidification in a group of children diagnosed of idiopathic hypercalciuria. PATIENT AND METHODS: 36 children were studied, to those that were determined the pCO2 (UpCO2) maximum urinary with two different stimuli, acetazolamide and sodium bicarbonate (NaHCO3). At 33 of them, was performed an acidification test with frusemide stimulus. We studied a control group of 13 healthy children so much for the first one as the second tests and other 14 healthy children for the acidification test with frusemide. RESULTS: In the tests performed with NaHCO3 and acetazolamide stimulus, they were not proven differences in the values of UpCO2 neither in the urinary concentration of HCO3- (UHCO3-) than control children. Nevertheless, the UpCO2 and the concentration of UHCO3- in the patients were significantly lower with acetazolamide with regard to the NaHCO3 stimulus. In the acidification test with frusemide, significantly lower values of titratable acid and ammonium were obtained than control children. CONCLUSIONS: In children with idiopathic hypercalciuria, the capacity of secretion of H+ is normal, what is evidenced, especially, when studying the maximum UpCO2 after stimulus with NaHCO3. When diuretics are used as stimuli, exists more negative results that can be due to a certain partial resistance to the action of the same ones or to that are less potent to induce the secretion of H+.

Acidosis, Renal Tubular↗
PubMed2001

[Study of renal function in infants diagnosed with renal pyelectasis in the first year of life].

OBJECTIVE: To evaluate glomerular and tubular function in a group of infants diagnosed with pyelectasis. PATIENTS AND METHODS: We studied 14 patients diagnosed with renal pelvis dilatation in-utero or during the first year of life. Creatinine concentrations, urinary excretion of calcium, citrate, oxalate, N-acetyl-D-glucosaminidase (NAG), microalbumin and maximum urine osmolality after administration of intranasal desmopressin were determined. The latter three variables were determined at diagnosis and at the end of follow-up. RESULTS: In all patients creatinine levels were normal. In six patients (42.9%) maximum urine osmolality values were abnormal. In four patients NAG/creatinine concentrations were elevated and in another four patients (28.6%) albumin urinary excretion was elevated. These anomalies tended to return to normal but, at the end of the study, three patients (21.4%) showed increased albuminuria and one (7.1%) showed persistently defective renal concentrating capacity. Ten patients showed metabolic urinary anomalies, potentially leading to the formation of stones (isolated hypercalciuria in five [35,7%], hyperoxaluria in two and hypocitraturia in one, and hypercalciuria associated with hyperoxaluria in two). CONCLUSIONS: All patients showed normal glomerular function. Some patients presented increased albuminuria and moderate tubular function abnormalities, both of which tended to return to normal. Although studies with greater numbers of patients are needed, we propose that pyelectasis maybe a predictor of risk for lithiasis at later stages of life.

Biomarkers↗
PubMed1995

[Pollakiuria and idiopathic hypercalciuria in childhood].

OBJECTIVE: To determine the incidence of pollakiuria in children with idiopathic hypercalciuria. METHODS: The clinical records of 56 children with idiopathic hypercalciuria were reviewed. In addition to pollakiuria, they were evaluated for other associated disorders, maximum urinary osmolality, urodynamic study and overall clinical course. RESULTS: Nine children (16%), 4 boys and 5 girls, presented with pollakiuria associated with urgency, nocturnal enuresis, hematuria and urinary incontinence. Two showed normal urodynamic studies and unstable bladder was observed in another case. All but one patient preserved normal renal concentration capacity. The course of the micturition symptoms was satisfactory and only three cases required pharmacological treatment. CONCLUSIONS: In the absence of urinary infection, pollakiuria might suggest the presence of hypercalciuria, a condition that can be managed successfully following correct diagnosis and treatment. Renal concentration capacity is not reduced by hypercalciuria.

Calcium↗
PubMed1991

Nephrocalcinosis and idiopathic hypercalciuria.

In a sample of 28 children diagnosed as having idiopathic hypercalciuria, ultrasound studies showed nephrocalcinosis in 6 cases, the rest having normal sonographs. On biochemical comparison, the two groups were statistically distinguishable by means of three parameters. The group with nephrocalcinosis showed higher values of calciuria and calciuria versus magnesuria ratio (p less than 0.05), as well as lower maximum urinary osmolality (p less than 0.01) than the group with normal sonographs. A negative correlation was found between the calciuria values and the values obtained from the concentration test (p less than 0.05). At present, the factors favoring the deposit of calcium salts in children with idiopathic hypercalciuria are not yet fully known.

Calcium↗
PubMed1990

[Bladder instability and abdominal pain in children].

We are presenting herein three patients with bladder instability and recurrent abdominal pain whose symptoms disappeared after anticholinergic treatment. We propose urodynamic study in children with recurrent abdominal pain associated to frequency, incontinence, urgency or recurrent urinary infection.

Child↗
PubMed1988

[Effect of roasted wheat flour on the intestinal absorption and zinc metabolism of rats].

24 experiences have been carried in 8 younger Wistar female rats that been submitted to three different diets considering fibers and phytates, with the purpose to demonstrate if "gofio de trigo" of popular consumption in Canary Islands, and rich in these substances affects intestinal absorption of zinc in the diet. Authors have observed a very significant elevation of zinc in feces, during the control period. An important decrease of zinc in hair has been observed indicating a deficit of corporal ion although zinc in serum remained in its normal limit. Authors emphasize the fact that under these circumstances, removal of urinary zinc is not a useful guide for diagnosis of deficiency state.

Animals↗