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Biomedical subjects

V Gorgan

Publications and source records attributed to V Gorgan.

14 recordsLinked to original sources
PubMedDate not supplied

[Clinical and therapeutic observations on 34 cases of meningococcic meningitis].

The present paper reports on 34 cases of meningococcal meningitis admitted during the last three years to the Clinic of Communicable Diseases of Cluj. The incidence was higher in adolescents and young adults (76%). The clinical form was severe in 10 cases, medium in 19 cases and mild in 5 cases. All the patients recovered, with a mean duration of the disease of 9-12 days. No sequelae or relapses were recorded. The treatment was based upon penicillin G, 15 million U/day. In 17 cases sulfonamides were associated and in 5 cases chloramphenicol and ampicillin. In 29 cases intravenous, intramuscular or oral cortisone was administered and in 5 cases intrathecally. The results obtained in the cases treated only with penicillin were identical to those obtained by an associated therapy. Worthy of note was the decrease of the sensitivity of meningococci to sulfonamides and chloramphenicol and their increased resistance to tetracyclin and erythromycin.

Adolescent↗
PubMedDate not supplied

[Campylobacter pylori infection in chronic gastritis and gastric cancer].

The present paper analyses, in correlation with histologic lesions, the incidence of infection with Campylobacter pylori (CP) in patients with chronic gastritis, operated stomach, gastric neoplasm and healthy subjects. In chronic gastritis, incidence of infection with CP is 71.6%, significantly increased in comparison with the controls, in whom the positive percentage is 37.5. The most of the patients in this group suffered from superficial chronic gastritis. In the group with operated stomach, the CP infection included 48% of the patients studied; all had superficial chronic gastritis. In gastric cancer, CP bacteria appeared in 50% of cases. CP may represent a pathogenetic ring that starts the gastric process.

Biopsy↗
PubMedDate not supplied

Campylobacter pylori infection in gastric and duodenal ulcer.

The incidence of infection with Campylobacter pylori (CP) in gastric ulcer (GU) and duodenal ulcer (DU) and its correlation with the gastritis lesions associated to the two diseases, was investigated. In GU the incidence of CP infection was 76.3%, close to that in DU (71.4), but different from controls (33.3%). Chronic gastritis associated to gastric or duodenal ulcer is of variable severity, CP infection being the more often encountered the higher the severity of gastritis. Presence of CP was also observed in 75% of the cases associated also with intestinal metaplasia from UG. The diameter of CP-positive GU was significantly increased as compared with that in CP-negative GU. Type I GU was associated with CP infection in 81.8% of the cases. The results obtained allowed the conclusion that in GU and DU the incidence of CP infection is significantly higher as compared with that in controls but the pathogenetic relationship ulcer-bacterium is not yet elucidated.

Biopsy↗
PubMedDate not supplied

[Incidence of antibodies against hepatitis virus A (anti-HA) in a non-selected urban population].

Anti-HA antibodies were determined by radioimmunoassay according to the HAVAB-ABBOTT technique in 244 subjects, of whom 194 without hepatic involvement, 25 with non B hva and 25 former non B hva patients. Anti-HA anti-bodies were found in 67% of the healthy subjects and 100% of the patients and former hva cases. The incidence of anti-HA antibodies increases with age being in 30% of children and 83.5% of adults. A peak incidence was found between the ages 21 and 30 years. In the district investigated subclinical infection with HVA was frequent, beginning in childhood and up to the age of 30 years. The qualitative HAVAB test is adequate for epidemiological investigations; a quantitative variant is necessary for the diagnosis.

Adolescent↗
PubMedDate not supplied

[Post-transfusion hepatitis].

The incidence, aetiology, evolution, prognosis and treatment of PTH was studied in 253 cases selected from among 7224 patients with acute viral hepatitis, admitted to hospital during the 1973-1979 period. Following the rational application of transfusion and elimination of hepatitis virus B carriers, there was a three-fold decrease in the frequency of PTH. Control of the donors by contra-immunoelectrophoresis showed that PTH type B represents at least 26.8% of the total number of PTH. In order to eliminate PTH type B a more sensitive technique should be used in order to detect HBs Ag in the donors. The treatment being complex and hospitalization prolonged, the cost of PTH patients is greater than that of acute viral hepatitis patients, in general, justifying the additional expenses required for the prevention of PTH.

Adolescent↗
PubMedDate not supplied

[Diagnostic and prognostic value of antialbumin antibodies (AAA) in acute viral hepatitis].

The behaviour of antialbumin antibodies (AAA) was tested by immunodiffusion in 284 patients suffering from acute viral hepatitis. AAA were found in more than 80% of the cases, and in only 16% of the control lot. The AAA titer was higher the more severe was the clinical form of the disease. As the AAA titer appears to be a marker of functional alterations of the hepatocyte, the test might be used to check the recovery of convalescents after acute viral hepatitis.

Antibodies↗
PubMedDate not supplied

[Frequency and prognostic value of the "e" system in hepatitis B virus infection].

The frequency and prognostic value of the "e" system was determined in acute and chronic hepatitis patients and in blood donors by immunodiffusion on Abott rheophoresis plates. The incidence of HBe Ag in acute viral hepatitis was 20% at the beginning of the disease; its persistance indicated a prolonged evolution and a tendency to a chronic course. The presence of anti-HBe at the beginning of the acute disease may indicate the onset of a non-B hepatitis in an HBe carrier. In chronic hepatitis the incidence of HBe Ag was 58% and in blood donors only 6%. Anti-HBe was absent in chronic hepatitis and present in 15% of blood donors.

Hepatitis B↗
PubMedDate not supplied

[Spontaneous reactivation of the hepatitis B virus?].

The authors present 4 cases of chronic AgHBs positive hepatitis, with reactivations of hepatitis B virus. The reactivations occurred spontaneously, as mentioned in references. The authors appreciate that the cause of B virus reactivation bases upon factors which modify the immune status of the host. Alcohol is one of these factors, not yet mentioned in references as cause of virus B reactivation. Are also presented data about the existence of virus B mutants, in the studied patients, which could play a role in the reactivation of chronic hepatitis B.

Adult↗