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Biomedical subjects

V Grouls

Publications and source records attributed to V Grouls.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Vascular eccrine giant spiradenoma--a case report with histology and immunohistology of a rare variant of benign sweat gland tumors].

Giant vascular eccrine spiradenoma (GVES) is a rare variant of benign tumors of the sweat glands, which differs from common eccrine spiradenoma in both its size and vascularity. Clinically as well as macroscopically, this intradermal or subcutaneous encapsulated tumor might be mistaken for an angiomatous lesion or thrombosis. Histological examination reveals clearly delimited "cords" showing two types of cells, prominent blood-filled cavities and extensive hemorrhages. According to immunohistochemical findings, the epithelial cells contain cytokeratin, protein S-100 and carcino-embryonal antigen (CEA). Like the endothelial cells of vessels, some of the luminal epithelial cells also bind Ulex europaeus lectin; however, they do not show factor VIII-associated antigen.

Adenoma, Sweat Gland↗
PubMed1988

Trichoblastic fibroma (fibromatoid trichoepithelioma).

Six examples of so-called trichoblastic fibroma occurred in five females and one male. The age of the patients ranged from 46 to 70 years (mean: 61 years). Three tumours were on the back, one each on the left gluteus, right skull and left thigh; they were present one to 20 years and varied in size from 1.8 to 6 cm. The tumour nodules were easily shelled out at operation, and the macroscopic aspect was that of fibroma. Although there seems to be a close relationship to trichoepitheliomas, this tumour deserves a separation from classical conventional trichoepitheliomas and differs from these by size, consistency, involvement of deeper tissues, nodular character, unusual location, age of patients and additional histopathologic findings. In our opinion, these rare tumours may also be classified as fibromatoid trichoepitheliomas.

Aged↗
PubMed1988

Tartrate-resistant acid phosphatase containing cells in nodular fasciitis, proliferative fasciitis, and proliferative myositis.

Five cases of nodular fasciitis, three cases of proliferative fasciitis, and one case of proliferative myositis were investigated by tartrate-resistant acid phosphatase (TRAP) histochemistry on conventional paraffin-embedded material. In all cases varying numbers of enzyme-positive cells were detected. Cytological investigations revealed the presence of small round cells, elongated spindle cells, medium-sized mono- or binucleated cells, and multinuclear giant cells, the latter resembling osteoclasts. However, the typical ganglion-like cells were TRAP-negative in almost all tests. The TRAP-pattern may help to differentiate nodular fasciitis and allied lesions from inflammatory pseudotumours or organising haematomas, as the latter do not contain TRAP-positive cells. As TRAP appears to be a marker for a special population of phagocytizing and non phagocytizing histiocytes, nodular fasciitis and its proliferative variants may be assumed to be fibrohistiocytic tumorous conditions.

Acid Phosphatase↗
PubMed1987

Pseudolymphoma (inflammatory pseudotumor) of the liver.

Two small pseudolymphomas of the right liver lobe were incidentally detected at autopsy in a 85 year old female patient with a large ulcerating carcinoma of the stomach. Most of the lymphocytes and plasma cells produced IgA and lambda light chains, a few also kappa light chains. These tumors may also be classified as inflammatory pseudotumors of the liver.

Aged↗
PubMed1987

[Tricholemmal keratosis and tricholemmal cancer].

Three cases of tricholemmal keratosis and two of tricholemmal carcinoma are reported. All patients were female and the age range was from 71 to 83 years. These rare tumors occur on the face and are obviously the result of long-standing actinic skin damage. Clinically, verrucous hyperkeratosis or cornu cutaneum (keratosis) are observed and in the case of tricholemmal carcinomas, ulcerated tumor nodules. Histologically pale, glycogen-rich polygonal cells with signs of tricholemmal keratinization without the presence of a granular cell layer are characteristic features. Tricholemmal keratoses exhibit no atypia or only a mild form; however, carcinoma in situ may occasionally develop. In contrast, tricholemmal carcinomas are characterized by increased pleomorphia, an increase in the rate of mitosis, and an invasive growth pattern. The prognosis is favourable.

Aged↗
PubMed1987

[Pedunculated polypoid gangliocytic paraganglioma of the afferent jejunal loop of a Billroth II stomach].

A mobile pedunculated polypoid tumor was endoscopically removed from the afferent jejunal loop after gastrojejunostomy of a 54-year-old patient with anamnestic evidence of intestinal bleeding. Histologically epithelial carcinoid-like as well as mesenchymal paraganglioma- and ganglioneuroma-like patterns are mixed in varying portions, characteristic for gangliocytic paraganglioma. Immunohistochemically, serotonin, neuron-specific enolase, cytokeratin, vimentin S-100 protein and neurofilament were demonstrable. Gangliocytic paragangliomas are almost exclusively observed in the second portion of the duodenum, especially around the papilla Vateri and only two have previously been reported in the jejunum. The histogenesis of the tumors is unclear, but they may probably be either hamartomas, hyperplastic or neoplastic proliferations of so called endodermal-neuroectodermal complexes. Although gangliocytic paragangliomas contain a carcinoid-like component, they behave in a benign fashion, and metastases or recidives have not been noticed. Tumors with a pedicle may be endoscopically removed without complications.

Diagnosis, Differential↗
PubMed1985

[Dermatofibrosarcoma protuberans: transition to fibrosarcoma].

We report on two patients suffering from dermatofibrosarcoma protuberans showing areas of fascicular fibrosarcoma. Whereas the mitotic rate was very low in the classic storiform parts of the tumor, the dedifferentiated areas presented an increased mitotic rate up to 10 to 15 mitoses/10 HPF. Metastases did not occur. Clinically, such a tumor may be treated like typical dermatofibrosarcoma protuberans as long as the sarcomatous component is small and not prevalent.

Back↗
PubMed1985

[Microcarcinoidosis of the stomach. Diffuse hyperplasia of endocrine c ells and multiple polyp-like carcinoids].

A diffuse peptide microcarcinoidosis was observed both in a 56-year-old man with chronic atrophic gastritis and in a 33-year-old female with chronic atrophic gastritis and pernicious anaemia. Besides hyperplasia of endocrine cells at the base of gastric fundus and corpus mucosa with infiltration of the mucosal muscular layer multiple macro- and micropolyp carcinoids were present. In both cases serotonin was demonstrated immunohistochemically in the intestinal metaplastic mucosal changes, in the microcarcinoidosis foci and in the carcinoids. However, no appropriate clinical symptomatology was observed. The diagnosis can already be made by biopsy which must be deep enough and include gastric mucosa containing the mucosal muscular layer. Should gastric carcinoid be established histologically the other macroscopically normal mucosa must also be biopsied for exclusion of diffuse microcarcinoidosis as intermediate form of a multiple carcinoid. In such a case treatment consists of total gastrectomy.

Adult↗
PubMed1985

Reaction of bone marrow after cryo- and thermolesions on internal organs.

Focal thermo- and cryolesions were placed on one kidney and the liver of Wistar rats. The wound healing was investigated histologically and by tritiated thymidine autoradiography. Furthermore, the 3H labeling indices of neutrophilic and eosinophilic promyelocytes and myelocytes as well as that of erythroblasts were determined in bone marrow samples from femur and vertebra. Normal nonoperated rats and rats which underwent sham operation (simple laparotomy) served as controls. The cryonecrosis healed completely after 4 weeks, whereas thermonecrotic areas were still observed 12 weeks after operation. The maximum mesenchymal and epithelial proliferation occurred between the 2nd and 3rd postoperative days. In the bone marrow, the highest labeling indices were estimated in animals with thermonecrosis, with values remaining increased during the 2 weeks after operation. Significant differences between the bone marrow response after cryolesions and sham operation were not observed. Thermolesions of internal organs, for example, after electrocoagulation, evoke a persisting local granulomatous inflammation accompanied by a distinct bone marrow reaction probably because of the pure resorption of carbonized tissue components. Iatrogenic cryolesions, in contrast, are characterized by a quick and uncomplicated wound healing without a significantly increased proliferation of bone marrow cells, thus corresponding to the wound healing after sham operation.

Animals↗