BEHAVIORAL DIFFERENCES IN TWO CLOSELY RELATED LINES OF MICE.
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Biomedical subjects
Publications and source records attributed to V H DENENBERG.
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Mice in group 1 (controls) spent all their lives with other mice. Mice in group 2 had experience only with male and female rats after weaning; group 3 mice had no experience with peers-each litter was reduced to one pup, which was reared in isolation after weaning; group 4 mice were fostered to a lactating rat mother at approximately 3 days of age and thereafter lived only with rats. In adulthood group 4 mice were the least active and group 3 the most; mice in groups 2 and 4 preferred to spend time in a chamber adjacent to a rat, those from groups 1 and 3 in a chamber containing another mouse; when mice were paired off within experimental groups and given the opportunity to fight each other, the percentage of pairs in which 4 were, respectively, 44,27,100, and 0.
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Some rat pups were handled for 20 days in infancy, while others were not. When the rats reached adulthood the females were bred. Some of the offspring were left with their natural mothers, others were fostered to mothers of the same background (handled/nonhandled) as that of their natural mothers, while still others were fostered to mothers with a different background from that of their natural mothers. The offspring were weaned and weighed at 21 days; at 50 days, activity and defecation scores were obtained in the open field. The weights at weaning and the defecation scores at 50 days were significantly influenced by the experience in infancy of the "postnatal" mother, whether she was the natural mother or a foster mother. The natural mother and the foster mother jointly affected the open-field activity of the offspring.
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