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Biomedical subjects

V Haas

Publications and source records attributed to V Haas.

18 recordsLinked to original sources
PubMed2006

[Effects of nasal continuous positive airway pressure ventilation in infants with severe acute bronchiolitis].

OBJECTIVE: Usefulness of nasal continuous positive airway pressure (NCPAP) in severe acute bronchiolitis has been checked. The objective of this descriptive study was to evaluate the feasibility, safety and risk factors of NCPAP failure. POPULATION AND METHODS: One hundred and forty-five infants were hospitalised in our intensive care unit during the 2 last epidemics (2003-2004, 2004-2005). Among them, 121 needed a respiratory support, either invasive ventilation (N=68) or NCPAP (N=53). RESULTS: General characteristics were similar during the 2 periods. Percentage of NCPAP failure, defined by tracheal intubation requirement during the stay in paediatric intensive care unit, was quite similar during the 2 periods (25%), but number of NCPAP increased twofold. Whatever the evolution was in the NCPAP group, we observed a significant decrease in respiratory rate (60+/-16 vs 47.5+/-13.7 cycle/min., P<0.001) and PaCO2 (64.3+/-13.8 vs 52.6+/-11.7 mmHg, P=0.001) during NCPAP. Only PRISM calculated at day 1 and initial reduction of PaCO2 were predictive of NCPAP failure. Percentage of ventilator associated pneumonia was similar (22%) between the invasive ventilation group and infants who where intubated because of failure of NCPAP. Duration of respiratory support and stay were reduced in the NCPAP group (P<0.002). CONCLUSION: NCPAP appears to be a safe alternative to immediate intubation in infants with severe bronchiolitis.

Acute Disease↗
PubMed2002

[What can thoracic surgery accomplish in recurrent/second carcinoma of non-small-cell bronchial carcinoma?].

From 1990 to 2000, 2268 (29.9%) of 9600 lung cancer patients underwent resection for stage I to IIIA non-small cell lung cancer. Reinterventions were done in one hundred (3.5%) patients, for locoregional recurrence in 27, metachronous cancer in 42, metastasis or a third tumor in 31. A third intervention was performed in 23 patients and a fourth in two. The in-hospital mortality rate was 9%. The overall survival was 31.9% at five and 17.9% at ten years. The 5-year survival after the first intervention (reintervention) was 26% (11%) for local recurrence, 80.3% (27%) for metachronous cancer, 7% (0%) for recurrence of synchronous cancers and 0% (0%) for lung metastasis after a solitary primary lung cancer.

Carcinoma, Non-Small-Cell Lung↗
PubMed2000

One small community hospital library's successful outsourcing of document delivery: an ongoing study.

When DOCLINE was implemented in 1985, community hospital librarians were beginning to feel the economic pressures of the changing health care arena. However, staff and resources were often sufficient or plentiful. Now, fifteen years after the creation of DOCLINE, many existing small hospitals either no longer have a librarian, an assistant is managing the library, the librarian is managing one or more libraries of an integrated system, or the number of librarians has been reduced. A system that is heavily staff dependent is no longer feasible. In addition, as the role of the community hospital librarian evolves into one of instructor and patient education liaison, a system that does not permit the librarian to expand such services will be detrimental to the entire library program. Following is a discussion of one small community hospital's decision to outsource document delivery services as a result of staffing changes and the expansion of additional library programs.

Baltimore↗
PubMed1999

[Primary synovial sarcoma of the lung].

In the biopsy material of a polypoid intrabronchial lesion of a 54-year-old male patient with radiologically established lung tumor, spindle-cell neoplasia was seen. No clear histogenetic classification of the submucous tumor process was possible. After resection of the right upper lobe of the lung, including the results of additional immunohistochemical analyses, the tumor was classified as biphasic synovial sarcoma. This was suggested mostly by immunohistochemical detection of the epithelial membrane antigene (EMA) and of vimentin. Extensive clinical examinations ruled out the possibility of a primary tumor with extrapulmonary localization. This case report shows the problems faced in correctly classifying the histogenesis or the direction of differentiation in extremely rare cases of primary pulmonary synovial sarcoma. Especially in small biopsy samples showing a submucous spindle-cell tumor of the lung, apart from frequent sarcoma metastases, the presence of primary synovial sarcoma of the lung has to be considered in the differential diagnosis.

Antigens, CD↗
PubMed1998

Free medical news and current event Internet sites for medical librarians.

The world of medical advancements is moving at a record pace. New drug approvals, important discoveries, and the explosion of consumer information on the Web have prompted health professionals with the need to keep current with the latest news stories in order to satisfy patient questions. The medical librarian who keeps up with the latest medical news is a valuable resource for all health professionals. The following is a compilation of sites for medical news available on the Web. The sites are limited to those that do not charge a fee and that direct the user immediately to top health stories, as opposed to requiring the use of a search feature. This list is not exhaustive; rather, it represents some of the more common news sources.

Directories as Topic↗
PubMed1988

Lacking evidence for release of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy.

The effect of subtotal thyroid resection for thyrotoxicosis on concentrations of serum thyroid hormones and thyroglobulin (Tg), was determined in 10 patients during operation and the subsequent 18 days. Mean serum Tg responded drastically, increasing from a pre-operative value of 0.30 nmol/l to a peak value of approximately 26 nmol/l during operation followed by a gradual decline to levels lower than before surgery on day 18. Mean serum total thyroxine was 114 nmol/l pre-operatively and free thyroxine index (FT4I) 105 units. Both fluctuated only slightly during operation. Postsurgically, the mean values decreased to below 50% of the pre-operative level. Mean serum total triiodothyronine (TT3) was 1.46 nmol/l pre-operatively. It decreased during operation, reaching a nadir of 0.55 nmol/l on day 2, whereafter the concentration increased slightly. Mean serum reverse T3 (rT3) was 0.45 nmol/l pre-operatively, increased 62% during surgery, and decreased postsurgically. The mean value of serum thyroid stimulating hormone (TSH) was 0.61 mU/l pre-operatively and remained below 1 mU/l during and after operation, but from day 10 concentration began to rise steadily. It is concluded that the vast release of Tg during thyroid resection did not contribute to the concentration of serum T4 to an extent of clinical relevance.

Adult↗
PubMed1988

Urinary iodine excretion in a geographically stratified Danish population sample not affected by iodination programmes. A change towards higher values.

The excretion of urinary iodine was studied in a representative population sample from the county of Funen, Denmark, comprising 505 persons between 25-44 years of age, stratified according to geography, age, and sex. Urine samples were collected for 5 h during late afternoon and early evening. The 24-h iodine excretion was estimated on the basis of iodine and creatinine determinations using correlation equations determined in a pilot study of 50 men and women. The iodine excretion was significantly higher in men: 89 micrograms/24 h (median) than in women: 76 micrograms/24 h; the whole population: 85 micrograms/24 h. No significant differences were observed among the age groups studied. The iodine excretion was significantly higher in people living on small islands: 98 micrograms/24 h (median) compared with 84 micrograms/24 h in urban regions and 78 micrograms/24 h in rural districts. Median iodine excretion per gram of creatinine was 58.8 micrograms for the whole sample. The iodine excretion for men was 77% higher than reported in an earlier investigation performed in Funen, 1969, but still lower than internationally recommended (WHO).

Adult↗
PubMed1984

The impact of quality control materials on the performance of an internal quality control system: 2. Experiences from S-calcium analysis.

In this subproject the analysis of S-calcium was used for evaluation of the specified system of internal quality control. Decisions on acceptance or rejection of series were based on a non-human pool with a calcium concentration near the upper reference limit. In the parallel system, specimens from patients and healthy individuals were used together with other non-human pools to disclose changes in accuracy. The results were examined for false rejections and false acceptances. In all the rejections based on a mean rule with 9 controls and a pfr of 0.01, the parallel system supported the decisions. On 18 occasions the series were rejected based on a range rule with a pfr of 0.05. Ten of the rejections were confirmed by the parallel system, and the remaining eight times of the 165 series were close to the expected five per cent of false rejections. The matrix effect estimated from the human and non-human serum pools was less than 15 per cent of the total variation. This supported the convenient use of non-human control materials in the analysis of S-calcium. The total variation, CVt, was estimated to be in the range of 0.027-0.030. The median of the patient results could be a valuable tool in quality control, whereas the mean of patient results within the reference limits is of no value. In conclusion, the investigation confirmed the validity of a system for internal control of a specified quality.

Analysis of Variance↗
PubMed1984

The impact of quality control materials on the performance of an internal quality control system: 3. Experiences from S-triiodothyronine analysis.

In this subproject a method for S-triiodothyronine was used for evaluation of the specified system of internal quality control. Decisions on acceptance and rejection of series were based on results from a human pool with triiodothyronine concentration at the upper reference limit. In the parallel system specimens from patients and from healthy individuals were used in combination with artificial materials so that changes in accuracy, specificity, and detectability could be disclosed. The results were examined for false rejections and false acceptances. For all the seven rejections in 117 series due to a mean rule of 8 controls with a pfr of 0.01, the parallel system supported the decisions. In eight occasions the series were rejected due to a range rule with a pfr of 0.05; one rejection was confirmed by the parallel system and the remaining seven times out of the 117 series were close to the expected five percent of false rejections. A small systematic change in standardization of about eight percent was too small to be recognized by the quality control system. The specificity was not changed during the investigation period; all of the systematic changes were caused by variations in the standard materials. In conclusion the investigation confirmed the validity of the specified system of internal quality control.

False Negative Reactions↗
PubMed1983

Optimizing the lymphocyte transformation test in whole blood. I. Optimum conditions for thymidine incorporation.

The correlation between mitogen concentration and H3-thymidine incorporation can be described mathematically by a sigmoid dose-response curve. Thymidine incorporation/lymphocyte (Ti/Ly) was calculated to facilitate comparison of results. It was highest at a blood dilution of 1:50, lower at 1:10 or 1:250. Ti/Ly obtained with optimum concentrations of PHA was higher than with ConA. Advantages of this optimized method for whole blood over Ficoll-separated mononuclear cells are the higher Ti/Ly, the smaller quantities of blood required and the lower experimental effort.

Cell Separation↗
PubMed1983

Optimizing the lymphocyte transformation test in whole blood. II. Kinetics of thymidine incorporation.

From the 2nd day of incubation on, the thymidine incorporation per incubated lymphocyte increased exponentially with time. The duration of the exponential growth phase was inversely correlated with the number of cells. Under optimum conditions the average time for the doubling of thymidine incorporation (Ti) was 15.7 h. Ti after 1 day of incubation was taken as an equivalent for the number of proliferating cells. It was estimated that less than 20% of the incubated lymphocytes are stimulated by PHA under optimum conditions. In Ficoll-separated mononuclear cells, the percentage of cells stimulated by PHA was lower than in whole blood; the proliferation rate was not decreased.

Cell Separation↗
PubMed1981

Propranolol in the treatment of thyrotoxicosis. A randomized double-blind study.

Twenty-five patients with newly diagnosed thyrotoxicosis participated in a double-blind study of the added effect of propranolol during tiamazol treatment. During the trial, the effect of treatment was ascertained by estimation at regular intervals of the clinical score (Crooks-Wayne index), free thyroxine index, serum triiodothyronine, serum reverse triiodothyronine, serum thyroglobulin and serum thyroglobulin antibodies. Both groups became euthyroid within two weeks. No statistically significant difference in the values for the clinical score or for any of the laboratory parameters measured was found between propranolol- and the placebo-treated patients. It is concluded that propranolol has no beneficial effect on tiamazol-treated hyperthyroid patients.

Adult↗