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V Haegi

Publications and source records attributed to V Haegi.

11 recordsLinked to original sources
PubMed1989

[Short-term therapy of lung tuberculosis using a fixed combination of isoniazid, rifampicin and pyrazinamide. Results after 2 years].

Treatment of tuberculosis should be as short and as simple as possible in order to improve patient compliance; and combinations of at least three drugs should be used in order to kill the different populations of mycobacteria and to avoid development of drug resistance.--In a controlled multicentre study two regimens were compared in 93 patients with newly-diagnosed pulmonary tuberculosis: 1) Six-month therapy (47 cases): Daily rifampicin and isoniazid, supplemented with pyrazinamide for the first 2 months. A tablet with a fixed combination of 120 mg rifampicin, 50 mg isoniazid and 300 mg pyrazinamide (Rifater) was used. 2) Present Swiss standard therapy (46 cases): Daily rifampicin, isoniazid and ethambutol for 2 months followed by rifampicin and isoniazid for 7 months.--The time-course of culture negativation and the frequency of adverse events were similar in the two groups. During a follow-up period of at least two years only one relapse was observed in the six-month regimen, 3 months after completion of treatment. This was one of three patients with pretreatment resistance to isoniazid. Nevertheless, two of them were cured with the six-month regimen containing Rifater.--Patient compliance, assessed during outpatient treatment by detecting isoniazid metabolites in the urine, was very good (93% of tests were positive in each group).--These results with a follow-up of more than 2 years, indicate that short-course therapy of 6 months duration with the fixed combination tablet may be recommended as treatment of choice in pulmonary tuberculosis except in cases of isoniazid resistance and other special situations (i.e. large cavitations, large number of viable bacilli).

Adult↗
PubMed1989

Respiratory muscle training in multiple sclerosis: a pilot study.

We assessed the effects of respiratory muscle training (RMT) in patients with multiple sclerosis (MS) on vital capacity (VC), maximal static inspiratory (PImax) and expiratory (PEmax) pressures and maximal voluntary ventilation (MVV). Eight patients (mean age 53, range 42 to 65 years) with stable disease and respiratory muscle weakness (RMW; VC = 83%, PImax = 64%, PEmax = 41%, MVV = 62% of predicted value) underwent a 4 +/- 1 week RMT program using inspiratory and/or expiratory resistive loads. Results showed changes in PImax (+31%, p less than 0.02), PEmax (+31%, p less than 0.05), and MVV (+21%, p less than 0.05); VC was unchanged (+1%). Thus in these patients, RMT improved respiratory muscle strength and ventilatory capacity. RMT may be an additional method of rehabilitation in selected patients with MS, in whom RMW contributes to exercise intolerance, coughing and talking impairment.

Adult↗
PubMed1987

[Extrapulmonary tuberculosis today].

In the past ten years 162 patients with extrapulmonary tuberculosis have been admitted to this hospital. They constituted 10% of the total number of patients with tuberculosis seen. The percentage of immigrants with extra-pulmonary disease was 39%, which was not only higher than the percentage of immigrants with pulmonary tuberculosis (25%) but also than their percentage in the total population (13%). The sites primarily affected were the pleura (28%), skeleton (23%) and urogenital tract (21%). Meningeal tuberculosis had the lowest incidence (1.9%). Altogether, 31% of the cases had additional pulmonary involvement which was active in half. Only one case proved to be an atypical mycobacteriosis. From our cases we conclude that modern invasive diagnostic methods are unevenly employed in Switzerland and surgical intervention is used too often, especially in the case of spondylitis. The favourable prognosis of purely conservative therapy is stressed. Based on recent reports in the literature, an attempt is made to establish guidelines for diagnosis and treatment.

Adrenal Cortex Hormones↗
PubMed1987

[Septicemia due to tuberculosis in HIV infection].

A 27-year old female HIV-positive patient developed septic tuberculosis, with mycobacterium tuberculosis typus humanus repeatedly found not only in sputum, bronchial secretion, blood and faeces but also in biopsy material from the liver. Although standard therapy with Pyrazinamid, Rifampicin and INH had to be replaced at times by Ethambutol or Streptomycin respectively, there was a surprisingly fast clinical and bacteriological improvement. Establishment of the diagnosis AIDS requires not only HIV-infection but also the occurrence of opportunistic infections. The latter include, according to the definition given by CDC, atypical mycobacteriosis, but not tuberculosis. Tuberculosis, however, is increasingly seen in HIV-infected patients. This observation allows us to question whether mycobacterium tuberculosis typus humanus should not be included in the list of opportunistic agents in AIDS. We conclude that in HIV infection the possibility of atypical and typical mycobacteriosis has to be taken into consideration. On the other hand, in tuberculosis patients at risk from AIDS the possibility of infection with HIV has to be considered. Tuberculin reactivity in HIV infected subjects is frequently missing and therefore can not be used for diagnosis. HIV-positive patients may require prophylactic treatment with INH, but BCG vaccination is strictly contraindicated. With early combination therapy continued for at least nine months, the prognosis may be good.

Acquired Immunodeficiency Syndrome↗
PubMed1979

[Candida coxitis (author's transl)].

Following drug-induced agranulocytosis and antibiotic and steroid treatment, sepsis due to candida albicans together with bilateral fungal coxitis developed in a 41-year-old female patient. Satisfactory eradication of the inflammatory process was achieved with combined treatment with amphotericin B and 5-fluorocytosine, so that mobilisation was possible after surgical fitting of bilateral total endoprothesis.

Adult↗
PubMed1976

[Immunologic investigations in tuberculosis and chemotherapy (author's transl)].

The influence of tuberculosis and chemotherapy of tuberculosis on the immunologic investigations was proved on 136 patients with tuberculosis and some cases with sarcoidosis, over a period of several months. The immunologic investigations should contribute towards the differential diagnosis of tuberculosis. A general control group was established and also followed up for several months. The diagnostic value of the immunologic investigations seems of little importance for the tuberculosis, the chemo-therapy of tuberculosis does not influence the immunologic situation. The relative frequent appearance of antibodies against cell nuclei and the plain muscles shows that in clinically similar cases we must be careful with the diagnosis of collagen diseases or lupus erythematodes.

Antitubercular Agents↗
PubMed1975

[New aspects of tuberculosis therapy].

The introduction of ethambutol and rifampicin has modified the therapy of tuberculosis. Therapy in hospitals or sanatoria can be shortened, and intermittent regimens (once or twice weekly under supervision) are possible. Better knowledge of the side effects of particular drugs, particularly rifampicin, (such as allergic reactions in intermittent administration and reduced effect of oral contraceptives) has been gained. Instead of mere supervision, preventive chemotherapy is given in many cases such as in recently discovered fibrotic lesions and in high risk cases (silicosis, treatment with corticosteroids and immunosuppressive agents)minadequate treatment may lead to functional impairment such as fibrosis and cor pulmonale. These aspects are discussed and the resultant guidelines for the treatment of tuberculosis are presented.

Contraceptives, Oral↗