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Biomedical subjects

V I Dontsov

Publications and source records attributed to V I Dontsov.

35 records · Page 2Linked to original sources
PubMed1980

[Toxic, anaphylactoid, and sensitizing properties of mercaptoquinolinates, metals of the 8th and 3d group].

A study was made of sensitizing, toxic and anaphylactoid action of eitht compounds of metals belonging to groups VIII and III of the periodic system. It was established that the activity depends on the nature of the central atom in the electronic structure of a complex salt ligand. The mechanism of histamine release was shown to be similar to that of specific antigen and to be related to preservation of the respiratory processes, of the microtubular and cell cyclic nucleotide systems. The sensitizing action of the compounds was shown by the reactions of the immediate and delayed types. Moreover, its realization did not require the presence of high molecular carriers, thus indicating that the latter is formed in the body.

Allergens↗
PubMed1980

Histamine releasing and histamine binding action of platinum and palladium compounds.

Platinum and palladium salts were shown to possess either histamine releasing or histamine binding properties. Both these effects were dependent on chemical structures of the tested compounds and might be drawn up in the following sequences; Pd greater than Pt, PtIV greater than PtII, NO2 greater than F greater than Cl greater than SCN greater than J, trans greater than cis. One of the possible mechanisms of anti-tumoral effect of platinum and palladium salts might be their marked histamine binding activity.

Animals↗
PubMed1980

[Comparative study of the toxic, anaphylactoid, and sensitizing properties of 5-sulfo-8-mercaptoquinolinates of metals of the 8th and 3d groups of the periodic table].

Pronounced allergizing action of the compounds of group VIII metals of the periodic system, observed in occupational pathology and commencement of their wide clinical application as cancerostatic agents require a comprehensive study of the properties of these substances. Anaphylactoid, toxic and genuine sensitizing action of 5-sulfo-8-mercapto-quinolinates of group YIII metals and those of group III metals having similar properties was studied and compared with reference to 8 compounds. It was shown that histamine liberation from mast cells induced by these substances as well as inhibition of the respiration of mast cells depend on the central atom and electronic structure of the ligand. The mechanism of histamine liberation observed was similar to that of specific antigen and was related to the preservation of the respiratory processes, the system of microtubules and cell cyclic nucleotides. The compounds tested were also capable of sensitizing the animal in intracutaneous injection of the substance without exogenous carrier. Sensitization developed according to the reaction of both the immediate and delayed types.

Allergens↗
PubMed1979

[Allergenic and anaphylactoid properties of carcinostatic compounds of platinum].

Different effects of platinum salts on the organism were studied comparatively. The toxic effect was estimated by LD50; the carcinogenic one--by the action on Ehrlich ascites tumor; the anaphylactoid effect was evaluated by the degree of the arterial pressure fall, the development of bronchospasm and an increased blood histamine level in cats under intravenous injection of platinum salts. The sensitization action of platinum salts was assessed on guinea pigs. All these effects are found to be dependent on the salts chemical composition, and they are manifested in an independent route.

Allergens↗
PubMedDate not supplied

[Potentiality of correction of the antioxidant enzyme system with electrically activated solutions].

Electrochemically activated solution (ECAS) exerts effects on the activity of antioxidative enzymes (catalase, peroxidase, and superoxide dismutase), by causing an increase in the reduced activity of the enzymes and a reduction in their superactivity. The baseline activity of enzymes is subject to expressed individual variations in both animals and man. The cause of ECAS effects is, probably, the training of the antioxidative system due to the excess of electrons at the negative redox ECAS potential.

Animals↗
PubMedDate not supplied

[Effect of aminoxidase activity regulators on the humoral immune response and proliferation of lymphoid and nonlymphoid cells].

DL-malic acid dibenzylhydrazide (I) and dihydrazide (II), inhibitors of aminoxidases, have been shown to inhibit immune reactions when administered at the phase of initiation but to stimulate the immune response and proliferation of lymphoid and nonlymphoid cells if given on the 2nd and 3rd day following immunization when the immune reaction is in progress. The intensity of local allergic reaction during passive skin anaphylaxis is reduced by I and enhanced by II if the compounds are administered 16 hrs prior to antigen challenge.

Anaphylaxis↗
PubMedDate not supplied

[System of pharmacologic control of histamine release by mast cells on exposure to different agents].

A scheme has been devised that makes it possible to assess a specific mechanism of action of any histamine-releasing agent. The scheme suggests a switch off of different stages of histamine secretion--interaction of a histamine liberator with surface cell receptors, entry of Ca2+ into the cell, temperature- and energy-dependent stages of histamine liberation, a stage that depends on microtubules, a system regulating histamine liberation with cyclic nucleotides. The scheme was made use of in clarification of the mechanism of histamine liberation on exposure of the mast cell to a specific antigen, to different doses of heavy metal salts, prednisolone and alkylating cross-binding agents.

Alkylating Agents↗
PubMedDate not supplied

[A resonance mechanism of immunomodulation by weak pulse currents (experimental study)].

The specific features of weak pulse current effects on immune rosette-formation in mice have been investigated. It has been demonstrated that there is a possible resonance (in the range of narrow values) mechanism of immunomodulation in mice with weak pulse currents. The parameters of this effect have been defined. These include 543 kHz, triangular or quadratic signal form with 5-10-min exposure just after animal immunization for immunostimulation and 4 hours later for immunosuppression. The resonance mechanism is one of the determinants when low-intensity factors have an influence on the body, which makes one use therapeutically safe and weak physical and other factors.

Adjuvants, Immunologic↗