Clonogenic cells forming colonies in agar cultures in diffusion chambers and those isolated from subcutaneously transplanted Lewis lung carcinoma do not differ in their sensitivity to 60Co gamma-rays with respect to tumor growth stages. The dose-survival curves for all studied cells are S-shaped with a small shoulder. A cumulative dose-survival curve for malignant clonogenic cells is characterized by the average value of mean lethal dose D0 = 2.24 Gy and extrapolation number n = 2.0. When exposed to gamma-neutron-radiation (252Cf) malignant clonogenic cells exhibit a nearly exponential dose-survival curve with D0 = 0.56 Gy (with respect to a neutron component). The RBE of gamma-neutron radiation (252Cf) is 2.5.

Animals↗

PubMedDate not supplied

[Radiosensitivity of human bone marrow stromal cell precursors irradiated in vitro in bone and in a cell suspension and the modifying effect of hypoxia].

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Bone Marrow↗

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[Radiosensitivity of mouse bone marrow cells that form granulocyte-macrophage colonies in diffusion chambers].

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Animals↗