PubMed Health⌕ Search

Biomedical subjects

V I Govallo

Publications and source records attributed to V I Govallo.

9 recordsLinked to original sources
PubMed1978

[Leukocyte adhesion suppression reaction for determining the immunological reactivity of oncological patients].

By means of the reaction of inhibition of leucocytes adhesiveness, suggested by Halliday and his coworkers, the authors examined the immune reactivity of 52 oncological patients and 25 healthy donors. The specific cell activity was observed only in oncological patients, and mainly against the antigen from autologous or histologically identical tumor. In a third of patients under examination blood serum would block the specific cell activity. The intensity of the reaction was enhanced in immunotherapy with FHA activated lymphocytes. The sensitivity of the reaction involved proved to be higher than that of the reaction of lymphocytes migration inhibition by the same antigens.

Antigen-Antibody Reactions↗
PubMed1976

[Indices of cellular and humoral immunity following surgery intervention for malignant bone tumors].

The immunity indices were studied in 35 patients, operated upon for various types of osteosarcomas, as well as the nonspecific reactivity of T-and B-lymphocytes and the specific immune response of lymphocytes. The system of peripheral T-lymphocytes in these patients is being inhibited with the primary tumor progression and an unfavourable postoperative course. In a continuous (from 1 to 15 years) favourable course of the disease postoperatively a persistent restoration of T-lymphocytes reactivity was noted. The specific antitumor immunity was found at every stage of the disease, but its suppression with serum (a blocking effect) seemed to be an unfavourable factor from the prognostic point of view, it was more frequently observed in patients with a progressive tumor growth. The operation proper after a provisional nonspecific suppression resulted in enhancement of the immune reactivity.

Adolescent↗
PubMed1975

[Immunological study in carcinogenesis. Distribution of tissue incompatibility antigens (system HL-A) in oncological patients].

By means of a micromethod of lymphocytotoxic test the content of eleven HL-A antigens (1, 2, 3, 5, 7, 8, 9, 10, 11, 12 and 13) was studied in 200 healthy human subjects, 100 patients with rheumatoid polyarthritis and 82 patients with bone tumors. The latter included 50 patients with benign tumors (osteoblastoclastomas, chondroblastomas, chondromas, non-osteogenic fibromas) and 32 patients with malignant tumors (chondro- and osteosarcomas, Ewing sarcoma, malignant osteoblastoclastomas). It was found that in patients with different bone tumors antigen HL-7 was encountered reliably more frequently than in control groups, in patients with malignant tumor also antigen HL-A10 was more often detected. The most frequently observed haplotyes in oncological patients were HL-A3/7 and HL-A2/7. In patients with rheumatoid polyarthritis antigen HL-A3 was found more rarely and antigen HL-A10 more frequently than in healthy subjects. The most frequent haplotypes in this group were as follows: HL-A2/7, HL-A2/8 and HL-A11/12. The possible mechanisms of the relationship between HL-A antigens and the development of pathology are discussed. Some considerations are offered concerning the possibility to utilize HL-A typing for an accessory differential diagnosis.

Arthritis, Rheumatoid↗