Biomedical subjects
Publications and source records attributed to V I Izmest'ev.
The immediate and the remote effects of the total one-time uniform irradiation with arsenid-hallium laser (wavelength 0.89 mu, pulse power 450 W, pulsed mode 80-3000 Hz) on the new-born Wistar rats have been examined. The complex of tests illustrated the biotropical effects of used laser regimes. The stimulating or braking of the animal's growth was observed in accodanse with the laser regime.
Acute 12-minute exposure of laboratory rats to microwaves with specific dose rate (SAR) of 30 W/kg that exceeded a basal metabolism caused a transient response of hyppophysis-thyroid system of compensatory-adaptive character. Prolonged exposure to microwaves of less intensity (SAR = 6 W/kg, which approximately corresponds to basic metabolic rate for these animals) caused insufficiency of the function of thyroid control in a form of primary hypothyroidis.
The purpose of this article was investigation the development of the posterity rat (line Wistar) in the postnatal ontogenesis after combined and separate action of gamma-radiation (1.25 Gy at 20 days) and hyperthyroidism, provoked by toxic thyroid doses of 100 mg thyroidin per rat. It was shown that hyperthyroidism did not affect physical development of the irradiated posterity, but in a long-time period (7 month) it was revealed a decrease in ability to the training of posterity rats after the combined action of the factors.
Blockade of dopamine receptors by haloperidol and serotonin receptors by lysergic acid diethylamide in turtle visual cortex, effectively changes the modifying effect of agonists of opioid mu-, delta-, kappa-, and sigma-receptors: morphine, D-Ala2, D-Leu5-enkephalin, bremazocine and SKF 10.047, on dynamics of habituation of orthodromic evoked potential. Muscarinic cholinergic blocker atropine disturbs the habituation modification by morphine and bremazocine. Conclusion is made, that modifying effects of opiate agonists on habituation are the result of interaction of activated opiate and transmitter receptors.
The modulating influence of such specific agonists of opiate mu-, delta-, kappa- and sigma-receptors as morphine, D-Ala2, D-Ley5-enkephaline (DADL), bremazocine, and SKF 10,047 as well as that of naloxone, their specific blockator, on habituation of orthodromic evoked potential in the visual cortical area was studied in turtles. In spite of equal degree of suppression of evoked potentials by the agonists used, their ability to modify habituation was different. Morphine, bremazocine and SKF 10,047 were of high effectivity while DADL was of low one.
The influence of polycomponent solutions of agonists of opiate mu-, delta, chi- and sigma-receptors (morphine, D-Ala2, D- Ley5 -enkephalin, bremazocine, SKF 10,047) and of met-enkephalin on the habituation of orthodromic evoked potential in the visual cortical area was studied in turtles. Interaction between the different types of opiate receptors was observed at their combined activation. The interaction resulted in an enhancement or attenuation of modulation of separate phases of evoked potential habituation which differed from simple sum of effects during isolated activation of each type of receptors.
The purpose of the investigation is the study and analysis of combined influence of gamma-radiation (137Cs, 1.25 Gy during 20 days) and mercazolyl (20 mg/100 ml drinkable water) in utero on the physical developmental of the rats in the postnatal ontogenesis. It was shown, that antenatal separate influence both of gamma-radiation and mercazolyl induced the decrease of the strength endurance. The combined influence both of these factors induced essential decrease of the strength endurance.