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Biomedical subjects

V I Kharchenko

Publications and source records attributed to V I Kharchenko.

51 records · Page 3Linked to original sources
PubMed1978

[Therapeutic use of amiloride and its combinations with hydrochlorothiazide and furosemide in chronic circulatory insufficiency].

The clinical pharmacology of the diuretic amyloride was studied in 60 patients suffering from circulatory insufficiency of various origin. Midamor and moduretic of the "Merck" firm (USA) were used in a dose of 1 to 4 tablets. The duration of treatment was from 3 days to 18 months. It was found that under the effect of amyloride natriuresis increases moderately in patients with circulatory insufficiency with no simultaneous increase in the loss of potassium with the urine. As the circulatory insufficiency becomes more severe, the natriuretic and potassium-saving effect of the drug diminishes. Amyloride potentiates the diuretic and natriuretic effect of furosemide and hydrochlorothiazide well without increasing kaliuresis. In patients in whom the disease is less severe, two-week treatment with amyloride leads to an authentic increase in the total metabolic potassium in the organism. The patients tolerate the drug well. It is recommended for wide clinical use.

Adult↗
PubMed1976

[State of water-electrolyte metabolism in ischemic heart disease].

The state of the water-electrolyte metabolism was studied by the radio-isotope dilution technique in 115 patients with different forms of ischaemic heart disease and in 25 normal persons. It was established that all forms of ischaemic heart disease are accompanied by a significant potassium deficit imperceptible for blood and urine examinations of their electrolyte composition. The potassium deficit is most clearly expressed in patients with cardiosclerosis, especially in congestive heart failure. In a considerable part of the patients with acute myocardial infarction, including those without clinical signs of congestive heart failure, the rate of sodium and water metabolism is decreased, and the total body content of metabolizing sodium is increased. Sodium retention in the body is especially severe in patients with cardiosclerosis complicated by congestive circulatory insufficiency. The administration of diuretics in adequate doses was shown to result in normalization of the indices of sodium and water metabolism.

Adult↗
PubMed1975

[Use of aldactone-saltucine for patients with chronic circulatory insufficiency].

In 50 patients with congestive heart failure a compound diuretic drug aldactone--saltucine was used. Diuresis, urine excretion of sodium and potassium, rate of glomerular filtration and tubular reabsorption of water, as shown by endogenous creatinin, were measured in all patients. In 13 patients the study was conducted dynamically in 8 three-hour portions of urine during 24 hours. In 6 patients the drug was administred in combination with furosemid. In 11 patients the effect of several days of therapy with aldactone-saltucine upon the urine excretion of electrolytes and their plasma level was studied. The effect of the compound drug was evaluated separately in patients with IIA, IIB and III stage of circulatory insufficiency. Aldactone-saltucine was shown to execute a distinct diuretic and natriuretic effect that lasts for 24 hours after a single dose. The drug has also a clear potassium-preserving action that manifests itself in a low level of potassium excretion with urine and an elevation of a potassium plasma level. A combination of aldactone-saltucine with furosemid considerably increases diuresis and natriuresis, without any signifcant increase in potassiuresis, which permits to use these drugs in the severest cases of congestive heart failure.

Adult↗
PubMedDate not supplied

[Mathematical modeling of the kinematics of a pilot's head while catapulting into an air stream].

The trajectories of head movements in the helmet and velocities of impact contact with the seat and anterior of the cockpit were calculated as applied to every stage of the catapulting process and mass-inertia parameters of helmets taken into account. Kinematic models were used to describe biomechanic parameters of the head-neck system. Special attention was given to the case of catapulting to the air flow. The effect upon the nod of aerodynamic forces acting on the human body and the catapult ejection seat at air flow velocities of 700-800 and 1300 km/hr was calculated.

Aerospace Medicine↗
PubMedDate not supplied

[The main approaches to reducing cardiovascular morbidity and mortality in Russia].

Analysis of medical statistical data and of the socioeconomic situation in the country brought the authors to a conclusion that at present the principal factors responsible for cardiovascular diseases, specifically, coronary disease and cerebrovascular disorders, are environmental factors, such as chronic stress, alcoholism and hard drinking, violation of social and hygienic norms of labor, and a number of factors related to medicine: no prophylactic check-ups and unavailability of effective drugs. "Internal risk factors" should not be disregarded as well: hypercholesterolemia, arterial hypertension, etc. Based on their results, the authors propose measures aimed at limitation of overall stress exposures, alcoholism and hard drinking control, sociohygienic labor protection, re-creation of a system of effective prophylactic check-ups, and making present-day effective drugs available for the population.

Aged↗
PubMedDate not supplied

[Essential measures of an organizational-medical character aimed atdecreasing the incidence of diseases of the circulatory system and mortality caused by them in modern Russia].

Mortality caused by diseases of the circulatory system is analyzed on the basis of files of the Ministry of Health and of the State Statistical Committee of Russia and the results are correlated to the objective parameters reflecting the potentialities of cardiological service in Russia and the actual status of prophylaxis, including regular check-ups. Conclusions are drawn and recommendations offered.

Cardiology↗