There tends to be an activation of blood kinin system in individuals with a prior acute grade I radiation sickness in the period of remote sequelae (six yr after irradiation). It is suggested that changes in the proteolytic processes may play a role in the natural course of the diseases in the individuals with a history of acute radiation sickness (pathology of the gastrointestinal tract, vegetovascular dystonia etc.). The disturbances revealed are of pathological nature and require therapeutic measures to be taken aimed at clearing them up.

Acute Disease↗

PubMedDate not supplied

[The morphofunctional indices of the erythrocytic link in hemopoiesis in persons constantly working in an area of intensified radioecological control].

A study of the peripheral blood indicates that persons constantly working in the zone of rigid radiation control showed a statistically valid reduction of the hemoglobin concentration, appearance of spinous and spheric erythrocyte forms, reduction of the mechanical resistance. Simultaneously 18% of males and 26% of females revealed moderate hypochromic anemia with a normal level of serum iron. The intensity of Fe-transferrin electron paramagnetic resonance was statistically reduced, that may be related to reduction of trivalent iron to bivalent and formation of a pool of free bivalent iron--a potent inductor of lipid peroxidation. Activation of oxidative processes in blood is confirmed by significant fluctuations of the blood ceruloplasmin level.

Ceruloplasmin↗

PubMedDate not supplied

[The blood kinin system in persons exposed to ionizing radiation as a result of the accident at the Chernobyl Atomic Electric Power Station].

Condition of blood kinin system was studied in persons engaged on liquidation of Chernobyl accident sequels in 1986 and subjected to levels of ionizing radiation ranging up to 1 Gy. Activation of kininogenesis in such persons manifested in rise of the initial protaminolytic blood activity, partial decrease of prekallikrein level and imbalance on the part of the blood inhibitory potential in the form of alpha-2-macroglobulin level fall and increase of general blood antiproteolytic activity.

Accidents, Occupational↗

PubMedDate not supplied

[The current aspects of the treatment of patients with chronic lympholeukemia].

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Antibodies, Monoclonal↗

PubMedDate not supplied

[Myelodysplastic syndromes: their pathogenesis, diagnosis and differential diagnosis].

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Diagnosis, Differential↗

PubMedDate not supplied

[Dynamic hematopoietic system function in persons exposed to ionizing radiation (1986-1993)].

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Blood Cells↗

PubMedDate not supplied

[Current treatment methods in myelodysplastic syndromes].

Modern literary data about the treatment of myelodysplastic syndromes are reviewed. There have been analysed traditional methods and recent scientific achievements, such as using of the colony-stimulating growth factors and bone marrow transplantation.

Antineoplastic Agents↗