PubMed Health⌕ Search

Biomedical subjects

V I Lim

Publications and source records attributed to V I Lim.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Kinetic, energetic and stereochemical factors determining molecular recognition of proteins and nucleic acids].

It is shown within the framework of stereochemical modeling that disruption of water shells of proteins and nucleic acids is confronted by significant kinetic barriers caused by the breaking of hydrogen bonds. The structure of the water shells is dictated by the surface of proteins and nucleic acids, therefore the kinetic barriers due to disruption of the water shell are strongly distinct from each other on different parts of the shell. This, in turn, means that the probability of participation of different parts of the protein and nucleic acid surfaces in intermolecular interactions should be varied through a wide range, i.e. the water shell should strengthen selectivity of molecular recognition.

Allosteric Site↗
PubMedDate not supplied

[Cotranslational, cosecretory protein folding and its renaturation from a denatured state].

On the basis of the available experimental data on structure, biosynthesis and secretion of globular proteins it is concluded that an alpha-helix is a starting conformation at formation of the native structure of any globular protein (alpha-helical model for initiation of protein folding). The structural invariant (clusterization of hydrophobic side chains on the alpha-helix surface) in the amino acid sequences of globular proteins is found which is predicted by alpha-helical model for the initiation of protein folding. The model predicts the pyramidization of the atoms C and N of peptide groups during the formation of spatial structure of proteins and a number of other effects that can be put to the experimental test. In the work the mechanism for protein translocation across membrane lipid bilayer is also suggested.

Amino Acid Sequence↗