The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.

Animals↗

PubMedDate not supplied

[The blood-stimulating properties of lysine baicalinate].

The possibility of stimulating hemopoiesis inhibited by a single dose (2.0 Gr) of total irradiation with Lysini Baicalinatum, a vegetable origin drug, has been studied on CBA mice. A 3-fold drug administration (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation promoted bone marrow erythropoiesis and less granulopoiesis. A mechanism of Lysini Baicalinatum stimulating effect is connected with intensification of hemopoiesis inducing microenvironment's functional activity.

Animals↗

PubMedDate not supplied

[Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patents with lung cancer].

Hemopoiesis was studied in 88 patients with lung cancer during antitumor chemotherapy and its combination with a dry SB extract. Administration of the plant preparation was accompanied with hemopoiesis stimulation, intensification of bone-marrow erythro- and granulocytopoiesis and increase in the content of circulating precursors of the type of erythroid and granulomonocytic colony-forming units.

Adenocarcinoma↗

PubMedDate not supplied

[Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy].

Cytostatic therapy of patients with lung cancer is attended with decrease in the relative number of T-lymphocytes and their theophylline-resistant population. Patients who were given SB showed a tendency towards increase of these parameters during antitumor chemotherapy. The immunoregulation index (IRI) in this case was approximately twice the background values during the whole period of investigation. The inclusion of SB in the therapeutic complex promotes increase in the number of immunoglobulins A at a stable level of immunoglobulins G.

Adjuvants, Immunologic↗

PubMedDate not supplied

[A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors].

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Animals↗