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V I Lotova

Publications and source records attributed to V I Lotova.

5 recordsLinked to original sources
PubMed1977

[DNA synthesis in connective tissue elements of regenerating skin under the influence of thyrocalcitonin and hypoxia].

The influence of TCT on the proliferation activity of the connective tissue elements of the regenerating skin in normal and lowered partial oxygen tension was studied by means of H3-thymidin autoradiography. Continuous saturation of the organism with exogenous TCT is characterized by an increase in the count of cells during the S-period of mitotic cycle, the DNA synthesis intensification, and a considerable decrease in the number of silver grains over the nuclei in the course of the 24-hour observation period; this can testify to the acceleration of the cell passage of mitotic cycle stages in normal and low partial oxygen tension in hypoxia.

Animals↗
PubMedDate not supplied

[The effect of somatotropin on the healing of skin wounds under hypoxic conditions].

Using cytological, histological, histochemical and histoautoradiographic methods, it was demonstrated that skin recovery in the hypoxic state can be stimulated by somatotropin (STH). STH was shown to stimulate wound healing at every stage: cell migration to the injured area was accelerated, microbial phagocytosis and proliferation of epithelial and connective tissue cells were activated. This led to faster granulation and epithelialization of the wounded surface. The de novo formed epithelium showed a higher activity of succinate dehydrogenase and the granulation tissue - a higher activity of alkaline phosphatase. The hormone treatment reduced destruction of cell elements, newly formed vessels and fibrous structures of the wound which was caused by the hypoxic effect.

Animals↗