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Biomedical subjects

V I Mil'chakov

Publications and source records attributed to V I Mil'chakov.

9 recordsLinked to original sources
PubMed1992

[Assessment of myocardial function and metabolism in patients during aortocoronary bypass surgery after hypoxia-reoxygenation].

The myocardial function and metabolism were assessed in 12 patients with coronary heart disease intraoperatively during aortocoronary bypass surgery. The antioxidative properties of the blood of the heart were found to become lower along with activated peroxidation after the major stage of an arrested heart operation, that correlated with depressed myocardial function.

Adult↗
PubMed1986

[Contractile function and antioxidative system of the myocardium of the intact rabbit during hyperbaric oxygenation].

Daily exposures of rabbits to the HBO (2 ata, 1 hr) enhanced activity of glutathione-peroxidase for all 28 days of exposure. Other parameters of the antioxidative defence and the contractile function remained unchanged. The 2.5-ata oxygenation sharply reduced the activity of antioxidative enzymes, the antioxidative activity of lipids, and the tissue resistance against the induced peroxide oxidation of lipids. The heart contractile function was obviously worsened. Sites of necrosis appeared in the myocardium tissue. Increase in oxygenation seems to lead to changes of adaptation of the antioxidative system, but the exhaustion of the latter's power reserves potentiates the toxic effect of hyperoxia.

Animals↗
PubMed1984

[Superoxide dismutase inhibition as a prerequisite for disordered myocardial function under oxygen loading].

Changes in the contractility of rabbit myocardium following administration of diethyl dithiocarbamate were studied to determine the role of superoxide dismutase (SOD) in cardiac support function. It was observed that in healthy rabbits, a 50% decrease in the left ventricle SOD level induced by the inhibitor was not followed by any considerable disturbances in myocardial contractility as determined without additional stimulation and load. HBO sessions caused appreciable disorders in heart contractility which could be partly prevented by SOD administration. In rabbits with adrenaline-induced heart lesions, depression of myocardial contractility induced by the inhibitor alone or in combination with intensive oxygenation was also observed.

Animals↗
PubMed1984

[Effect of combined use of hyperbaric oxygenation and alpha-tocopherol on the contractile function and various components of the antioxidant system of the heart after adrenaline lesioning].

A session of hyperbaric oxygenation (HBO) at 2.5 at. abs. conducted for one hour in rabbits with adrenalin heart affection (AHA) immediately after adrenalin administration prevented a decrease in the cardiac contractile function usually developing within two hours after AHA. On the third day of the follow up, rabbits with AHA receiving daily HBO displayed a decrease in the pump and contractile functions as well as in superoxide dismutase (SOD) activity and the antioxidant activity (AOA) of the left ventricle lipids. Combination of HBO sessions with the intra-muscular administration of alpha-tocopherol (50 mg/kg) made the decrease in SOD activity less pronounced and prevented both the fall in lipid AOA and the depression of the heart contractile and pump functions on the third day following AHA. It is suggested that the combined use of HBO and substances increasing the potency of the cell antioxidation system may become one of the principles of reducing HBO side effects and of expanding the potentialities of HBO in treating ischemic and adrenergic heart impairments.

Animals↗
PubMedDate not supplied

[Assessment of reperfusion damage to the myocardium by oxygen free radicals in patients with ischemic heart disease subjected to surgery with artificial blood circulation].

The study was performed on 47 patients with ischemic heart disease subjected to aortocoronary bypass surgery. The study has revealed adaptation changes of free-radical blood properties that led to the damage of the myocardium by oxygen free radicals. Blood sampling from the coronary sinus is of greatest diagnostic value, enhancement of antiradical properties of this blood indicate damage of the myocardium. Detection of lactate in coronary blood may be an early sign of hypoxic myocardial damage caused among other reasons by activation of free-radical processes. Abrupt changes from hypoxic to hyperoxic oxygenation may complicate the recovery of cardiac function, while an even regimen of oxygen supply with a certain tendency of hyperoxia and adequate myocardial protection will not promote damage of the myocardium.

Adult↗