Biomedical subjects

V I Mishin

Publications and source records attributed to V I Mishin.

10 recordsLinked to original sources

PubMed1997

[Intravascular coagulation as a typical concomitant of acute pulmonary tuberculosis].

Hemostasis and fibrinolysis, markers of intravascular coagulation (IC), hemorrhagic parameters, and platelet aggregatory properties were studied in 119 patients with various types of pulmonary tuberculosis. In patients with active pulmonary tuberculosis, IC was found to be a persistent and important component of a pathological process which both plasma factors and circulating cells were involved in. In most critical patients, the degree and rate of spontaneous and stimulated platelet aggregation were decreased, when stimulated, the rate of increases in the mean volume of aggregates was yet higher in these patients than in the controls. The latter created an additional prerequisite for progression of microthrombogenesis.

Acute Disease↗

PubMed1996

[Diagnosis and treatment of acute progressive tuberculosis types].

An examination was made of 77 patients with extensive segmentary and lobular pulmonary tuberculous lesions: caseous pneumonia (n = 26), infiltrative caseous pneumonia (n = 18), fibrocavernous pneumonia complicated by caseous pneumonia (n = 16), and disseminated tuberculosis (n = 17). All patients had destructive changes; in 82.7% of patients the caverns were large and great in size. Bacteria were isolated in 94.8%, mycobacterial drug resistance was noted in 51.8%. Four variants of the course of a disease were identified: 1) that with predominance of the intoxication syndrome (41.6%); 2) that with respiratory failure (24.7%); 3) that with pulmonary hemorrhage (15.6%), 4) that added by secondary microorganisms (18.2%). Chemotherapy included a combination of 4 or 5 drugs along with pathogenetic tools, which stabilized a process in 80% of patients and arrested bacterial isolation in 69.5%. In 20%, the process continued to progress and in 3 of them died.

Acute Disease↗

PubMed1996

[Increased apoptosis of immunocompetent cells as a possible mechanism in the development of immunodeficiency in patients with acutely progressive tuberculosis].

The formation of immunodeficiency whose likely mechanism is apoptosis of some immunocompetent cells was studied in 35 patients with caseous pneumonia. The leading clinical sign of apoptosis in acutely progressive tuberculosis is significant lymphopenia (4-10%). Immunological studies indicated a substantial reduction in the count of T lymphocytes and their regulatory subpopulations of different phenotypes. In vitro mitogenic induction causes a decline of activated CD3+, CD4+, and CD8+ cells on the average by 10-40%, a decrease in the proliferative and synthetic functions, as compared with those in patients with infiltrative tuberculosis of the lung and healthy donors. Cytochemical findings in the same patients show that half the lymphocytes in the blood samples from patients with caseous pneumonia has profound intracellular metabolic disturbances. These cells are unavailable and undergo apoptosis, which determines immunodeficiency in patients with acutely progressive tuberculosis.

Acute Disease↗

PubMed1986

[State of the microcirculation and its relation to gastric function and structural changes in the gastroduodenal zone in recurrent peptic ulcer].

A total of 108 patients with peptic ulcer were entered into the study. Examination of the microcirculation in the eye conjunctiva and microvessels of biopsy specimens of the mucous membrane taken from ulcerous areas revealed that disease relapses were marked by pronounced disorders of the end blood flow. The extent of the disorders was found to be determined by the activity and localization of the pathological process, structural alterations in the mucous membrane of the gastroduodenal area, and by gastric functions.

Adolescent↗

PubMed1981