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V I Nesterov

Publications and source records attributed to V I Nesterov.

8 recordsLinked to original sources
PubMed2004

Morphofunctional changes in neurons in the temporal cortex of the brain in relation to spatial memory in bulbectomized mice after treatment with mineral ascorbates.

The effects of an antioxidant mixture of mineral ascorbates (MA) on the state of neurons in the temporal area of the cortex and the behavior of mice subjected to bulbectomy (BE) were studied; these mice, as demonstrated previously, are characterized by deficiency of spatial memory and the development of a neurodegenerative process in brain structures showing pathological changes in Alzheimer's disease. One month after BE, there were abnormalities in the cytoarchitectonics of the temporal area of the cortex, with loss of clarity of the boundaries between its layers because of dystrophy of pyramidal neurons and foci of loss of these cells. There were sharp increases in the numbers of neurons showing pyknosis, karyolysis, and vacuolysis on the background of decreases in neuronal density. Three weeks of treatment by addition of MA to the diet prevented the degradation of spatial memory in mice after BE and protected neurons in the temporal area of the cortex from degenerative changes. These results provide evidence for the possibility of prophylaxis of neurodestructive changes of the Alzheimer's type.

Animals↗
PubMed2003

[Morpho-functional changes of neurons in temporal cortex in comparison with spatial memory in bulbectomized mice after treatment with minerals and ascorbates].

The effect of antioxidant mixture of mineralascorbates (MA) on the status of neurons of brain temporal cortex and behavior of mice after olfactory bulbectomy (BE) was studied, as it was previously shown by us that these animals were characterized by a deficit of spatial memory and development of neurodegenerative process in brain structures, which are affected by Alzheimer disease. Disorganization of cytoarchitectonics of temporal cortex with the deletion of its layers as a result of dystrophy of pyramidal neurons and foci of their complete disappearance were shown 1 month after BE. The increased number of neurons with the phenomena of karyopyknosis, karyolysis and vacuolysis was observed with a concomitant reduction in neuronal density. Addition of MA to the diet for three weeks prevented the development of deterioration of spatial memory in mice after BE and protected the neurons of brain temporal cortex from the degenerative changes. The results obtained suggest the possibility of realization of prophylaxis aimed at the prevention of the development of Alzheimer-type neurodestructive processes.

Animals↗
PubMed1997

Bulbectomy-induced loss of raphe neurons is counteracted by antidepressant treatment.

1. Bilateral olfactory bulb ablation was performed in C57B1/6j mice (C57). Separate groups of bulbectomized mice were treated with either antidepressants (trazodone, 20 mg/kg i.p., or amitriptyline, 20 mg/kg i.p.) or saline daily for 14 consecutive days starting 14 days after surgery. 2. Celloidine-imbedded 10 microns-thick brain sections containing the nucleus raphe dorsalis (NRD) or locus coeruleus (LC) were stained for Nissl, and the number of functional and pyknotic cells was counted out of 500 total cell count for each animal in every experimental group: sham-operated, bulbectomized treated with saline or one of the two antidepressants. 3. Bulbectomy produced a significant 4 times increase in the proportion of pyknotic cells in NRD as compared to sham-operated control. Both antidepressants reversed the effect bringing the number of pyknotic cells to control level. The proportion of pyknotic cells in LC was also slightly increased (61%) in the bulbectomized mice, but only amitriptyline was able to reverse the effect. 4. Widespread degeneration of the neurons in NRD caused by bulbectomy may be involved in the serotonergic component of the bulbectomy syndrome. The ability of antidepressants to diminish bulbectomy-induced loss of NRD neurons may underlie their restorative effect on the behavior and neurochemical characteristics of bulbectomized animals.

Amitriptyline↗
PubMed1981

[Early pleurectomy for acute suppurative pleurisy in high-risk patients].

The results of 73 pleurectomies in complicated acute purulent pleurisy are discussed. Of the operated high risk patients one patient died. Recurrent empyemas were eliminated by means of 2--3 ribs thoracoplasty. The authors believe early pleurectomy to be quite endurable for most patients under conditions of pronounced intoxication and having severe associated diseases. In their opinion, pleurectomy can quickly liquidate the intoxication and favourably influence the development of the disease.

Acute Disease↗
PubMedDate not supplied

Transplants of olfactory mucosa in the anterior chamber of the eye: morphology, electrophysiology and biochemistry.

The olfactory mucosa from neonatal rats was transplanted into the anterior chamber of the eye. By 6-8 weeks after transplantation, morphological analysis showed the presence of olfactory sensory neurons in the grafts. The summated receptor potentials evoked by n-amyl acetate and camphor had the peak amplitude of about three times less and the duration of response of about 8-10 times more than those from normal olfactory epithelium. 6 h after beta-[3H]-alanine administration into the anterior chamber, more than 70% of the radioactivity was present in the carnosine fraction. This indicates that carnosine synthetase is present in the grafts. The presented data suggest that the grafts contain mature olfactory sensory neurons.

Animals↗
PubMedDate not supplied

[Development of olfactory epithelial grafts in the anterior chamber of the eye].

Olfactory epithelium of newborn rats was transplanted into the anterior eye chamber of the adult rat. Within 6-8 weeks the transplants increased in weight by a factor of 20-50. Morphological analysis has shown the cells similar to olfactory sensory neurones in the grafts. Electroolfactograms obtained with n-amyl acetate and camphor had the amplitude of about three times less and the duration of about 8-10 times more than those from the normal olfactory epithelium at the same concentration of stimuli. Within six hours after 3H-beta-alanine had been introduced into the anterior eye chamber, 72% of the label were present in the carnosine fraction. The data obtained suggest that olfactory sensory neurones appear in the olfactory epithelium grafts into the anterior eye chamber.

Animals↗