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Biomedical subjects

V I Novikov

Publications and source records attributed to V I Novikov.

At least 19 recordsLinked to original sources
PubMed1995

[The immunoadjuvant properties of hydroxyapatite with ultrahigh dispersity].

Chemically pure hydroxyapatite (HA) with particles less than 140 microns, less than 60 microns, and 0.01 to 0.03 microns was studied. The immunoadjuvant properties were assessed from the count of IgM-secreting cells and titer of IgG antibodies. Mice were immunized with Salmonella Vi antigen, using mixtures of the antigen with HA with different size of particles. Preparations with particles less than 60 microns and 0.01 to 0.03 micron had a reliable immunoadjuvant effect, whereas HA with particles of up to 140 microns in size did not show such an effect; these data are in line with those published elsewhere about HA as a surfactant. At the same time, our findings give grounds to speak about new prospects of HA use as a carrier of immunocorrective properties.

Adjuvants, Immunologic↗
PubMed1989

[The nature of the factors in immune lymph nodes that stimulate humoral and cellular immune reactions].

In the early period after antigen action, cells of the lymph node draining area of antigen injection produce a factor, which after its administration to intact mice, promotes intensified migration of myelopeptide producers in the bone marrow and increases bone marrow suppressor activity. Factor administration produced 2-3-fold increase in macrophage, peritoneal and lymph node count as compared with control, and 2-4-fold increase in humoral and cellular immune response. The factor consists of three easily identifiable components: Ig, MHC class II determinants and antigen determinants, that form unique complex similar to, or identical with the complexes detected in vivo within 3-6 hours after immunization in serum by other authors.

Animals↗
PubMed1989

[The clinical significance of the audible and mechanographic manifestations of mitral valve prolapse].

Graphic techniques were employed to examine 82 patients with mitral valve prolapse verified on echocardiography. In addition to the known acoustic symptoms, enhancement of tones III, IV and V was identified, especially in transmitral regurgitation, together with inverted alternating of the components of tones I and II. Mitral click (OS) was discovered in one third of the examined. Uninterrupted protodiastolic and presystolic murmurs were found more seldom. They were more well-defined on the phonocardiogram recorded from the esophagus, at the level of the mitral valve. The right and left ventricular apex cardiography made it possible to diagnose hyperdynamia of the left atrium, the shortening of isometric relaxation of the left ventricle on elongation of this phase of the right ventricle. Both the curves had the M-like deformation in the systole. On the apex cardiogram of the left ventricle, the O point was always low, and the OF amplitude (rapid ventricular filling) was increased. During regurgitation, the OF transformed to an anomalous positive wave (a "surge"). Simultaneous alterations in the jugular phlebogram and in both apex cardiograms reflect changes in all four heart chambers. In part of the examined, pulmonary hypertension was established with the aid of indirect techniques. Esophagoatriography turned out diagnostically instrumental, since in some of the patients it enabled identification of systolic expansion of the entire posterior wall of the left atrium (regurgitation).

Adolescent↗
PubMed1989

[Effects of immune lymph node factors on formation of immunological memory].

Two various fractions have been formed on the sephadex G-200 from culture supernatants of the lymph nodes cells isolated in 6h after immunization of animals by various antigens. The first fraction possessed the main biological properties peculiar to the earlier described factor of the immune lymph nodes (FILN), intensified proliferation of cells of the popliteal lymph nodes and increased the killer activity of peritoneal lymphocytes. Introduction of FILN simultaneously with ram erythrocytes led to more than a five-fold increase of humoral immune response.

Animals↗
PubMed1987

[Shape of the left ventricular cavity during ejection in patients with ischemic heart disease].

Different types of left-ventricular wall movement were demonstrated in normal subjects and coronary patients, the differences being due to different degrees of reduction in the equatorial diameter of the cavity in the ejection phase. Rationale are given for using the mean diameter for left-ventricular volume calculations. A linear relationship has been demonstrated between the degree of diameter reduction and the ejection fraction. The latter is shown to be dependent on left-ventricular end diastolic volume. Regional myocardial contractility, a parameter of high diagnostic value, based on segmental ejection fraction, is introduced.

Adult↗
PubMed1986

[Heart rhythm disorders in mitral valve prolapse syndrome and their treatment].

Sixty-three patients with the mitral prolapse (MP) syndrome and a variety of heart rhythm disorders were studied. Diagnostic signs of MP and arrhythmias associated with this conditions are discussed. The most common heart rhythm and conductivity disorders encountered were ventricular extrasystoles (in 27 patients) and paroxysmal atrial fibrillation (in 13). The mechanisms of cardiac arrhythmias and blocks, and principles of their treatment in patients with the MP syndrome are discussed.

Adolescent↗
PubMed1986

[Evolution of the shape of the left ventricular cavity at different phases of the cardiac cycle in healthy persons and ischemic heart disease patients].

Cineventriculo- and echocardiographic studies of left-ventricular cavity demonstrated an increase in the deep diameter and the thinning and outward displacement of the posterior wall during the isovolumic systole in normal subjects. This change of shape was however uncommon and, if present, less pronounced in 19 patients with marked coronary heart disease (CHD). In normal subjects, posterior wall movement amplitude was always greater than that of the anterior wall, whereas in coronary patients left-ventricular wall movement amplitudes were always similar. It is assumed that the lateral posterior wall displacement is due to a later myocardial activation in this area, while the absence of such movements is attributed to increased volume of ventricular cavity. The ratio of left-ventricular diameter to posterior wall thickness was actually below 3 in all normal subjects and above 3 in most of the coronary patients.

Adult↗
PubMed1985

[Echo- and electrocardiographic signs of different forms of hypertrophic cardiomyopathy].

Twenty-six patients with idiopathic and secondary hypertrophic cardiomyopathies were examined. The diagnostic value of echo- and electrocardiographic signs of hypertrophic cardiomyopathy is discussed, the more important among those being the thickness and shape of the interventricular septum, anterosystolic movement of the anterior cusp of the mitral valve, electrocardiographic evidence of left-ventricular hypertrophy and left-atrial changes, abnormal Q waves.

Adult↗
PubMed1985

[Calcinosis of the mitral valve ring: echocardiography and clinical data].

The clinical and echocardiographic picture of calcinosis of the mitral valve ring is described in 40 patients (mostly females of advanced age). Echocardiographic correlates and auscultatory manifestations of mitral calcinosis are analysed. Differential diagnosis against valvular heart defects is presented. The contribution of mitral calcinosis to the development of degenerative atrioventricular and intraventricular block is discussed.

Adult↗
PubMed1979

[Effect of the balanced inhibition of DNA and protein synthesis on the in vitro and in vivo proliferative activity of the lymphocytes].

Lymphocytes isolated from the rabbit peripheral blood were irradiated in vitro with 200, 400 and 1000 r doses and cultivated with phytohemagglutinin (PHA) doses and cultivated with phytohemagglutinin (PHA) at 37 degrees C during 48 hours. In several experiments cycloheximide, inhibiting protein synthesis, was added to the cells 60 minutes before and 30 minutes after irradiation. There was no apparent difference in the viability of irradiated cells with or without cycloheximide. The ability of lymphocytes of the popliteal lymph nodes for proliferation after PHA injection into one of the hind foot-pads of the irradiated mice was studied, as well. The injection of cycloheximide or puromycin into one of the hind foot-pads immediately after irradiation of the animals augmented the proliferation of lymphocytes in this extremity in comparison with contralateral one, 1.5-2 times. Cytosine arabinoside, inhibiting DNA synthesis, was not effective under these conditions.

Animals↗