[Effect of vitamin A and BCG vaccine on the plasma cell and lymphocyte count in the dermis in chemical carcinogenesis of the skin in mice].
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Biomedical subjects
Publications and source records attributed to V I Nozdrin.
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In the cells of RS-1 carcinoma and those of Iensen's sarcoma it has been stated that acceleration and inhibition of tumor growth induced by nonspecific influence (vitamin A, hydrocortisone, proserin) are accompanied by uniform morphological changes of intracellular structures. Therefore, it is possible to suggest that the changes observed reflect a certain cell adaptation to the altering environmental conditions (cell stress-reaction). The cell stress-reaction is presented morphologically and hence, can by systematized. An attempt of such systematization is suggested.
The reactive properties of tumors of epithelial origin (carcinoma RS-1) and connective tissue origin (Jensen sarcoma) are not analogous. Vitamin A inhibits the growth of carcinoma RS-1 and does not change the growth parameters of Jensen sarcoma. Hydrocortisone and proserine increase the growth rate of carcinoma RS-1. Hydrocortisone was found to inhibit the growth of Jensen sarcoma.
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