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Biomedical subjects

V I Pavlov

Publications and source records attributed to V I Pavlov.

8 recordsLinked to original sources
PubMed2004

[The state of microcirculation during use of long acting metoprolol].

The aim of the study was to assess the effect of prolonged action metoprolol on the microcirculation in patients with essential hypertension (EH). We studied 51 patients with EH aged 53,4+/-4,5 years. After 7-10 days of "wash-out" period and after 8 weeks of prolonged action metoprolol (betaloc ZOK) the state of microcirculation was investigated with the use of laser Doppler flux-metry (LDF). We found significant decrease in basically enlarged basal blood flow and the level of sympathetic activity, increase in the amplitude of cardiodependent waves, normalization of basal blood flow decrement in postural test, increase in capillary blood flow reserve in patients with stage I-II EH. We failed to observe any significant changes in the microcirculatory parameters in patients with stage III EH. Treatment with prolonged action metoprolol led to increase in the number of patients with normocirculatory type of microcirculation primarily due to the decrease in the prevalence of hyperemic type. We conclude that prolonged action metoprolol does not alter microcirculation in patients with EF. Moreover, at the early stages of EH it improves the functional state of peripheral hemodynamics due to suppression of sympathetic activity.

Hemodynamics↗
PubMed2003

[Microcirculation in hypertension].

Changes of microcirculatory vascular bed play important role in pathogenesis of essential hypertension. All components of the system of microcirculation including vessels and circulating blood are involved into pathological process. Resistance to blood flow is mostly formed in this system. Resistance depends on length, diameter of microvessels and viscosity of blood. In the process of the disease development the following signs of remodeling at the level of microcirculation emerge: decrease of density of vasculature, modification of the media/lumen ratio, increase of blood viscosity, slowing of angiogenesis, impairment of endothelial function. These phenomena can be both cause and consequence of hypertensive disease. Their heterogeneity depends on a variety of factors (duration, stage of the disease, etc.). It seems feasible to differentiate therapy in accordance with character and severity of changes in the system of microcirculation.

Animals↗
PubMed2002

Venusian "hot spots": physical phenomenon and its quantification.

An overall picture of the Venusian hot spots phenomenon is considered in the framework of the simplest conceptual models that admit the solutions in the form of steadily rotating "hot" vortices. Model assumptions take into account only those features of the middle atmosphere in the polar region of Venus that are supported by observational data and are essential for understanding the physical mechanism initiating similar vortices. The problem is analyzed in the framework of both the pointlike and petal-like models of cyclostrophic vortices. Interpretation of these models as an upper and lower bound of a complete theory allows one to find the region of existence of the regimes responsible for the Venusian hot spots and also to establish and assess numerically conditions under which such vortices can be formed. The emphasis is on a comparison of the theoretically established results with the observational data.

Journal Article↗
PubMed2002

[The state of microcirculation in hypertensive disease (essential hypertension)].

Skin microcirculation was studied by laser doppler flowmetry in 149 patients with essential hypertension (92 men, 67 women; mean age 50.1+/-4.9 years) and in 25 normotensive controls. In patients with hypertension prevailed pathological hemodynamic types of microcirculation. Hyperemic, spastic and congestive types were found in 20.1, 23.5 and 40.3% of patients, respectively, while only 16.1% of patients had normal hemodynamic type. Moreover presence and severity of microcirculatory disorders depended on stage of hypertension and level of blood pressure. Thus, patients with essential hypertension had pronounced impairment of microcirculation caused by structural and functional changes of microcirculatory vascular bed.

Adult↗
PubMed2002

[Complex assessment of efficacy and tolerance of metoprolol CR/ZOK in treating hypertension].

AIM: To study efficacy and tolerance of betaloc ZOK (Astra-Zeneca, UK) in patients with stage I-II (WHO classification) essential hypertension. MATERIAL AND METHODS: 27 patients were enrolled in the study (13 men and 14 women, mean age 40.6 +/- 1.57 years). Complete physical examination, ambulatory blood pressure monitoring, assessment of central hemodynamics, microcirculation were made before the treatment and on the treatment week 8. RESULTS: Monotherapy with betalok ZOK (50-100 mg/day) resulted in a significant lowering of mean daily, day and night systolic and diastolic arterial pressure. Variability index was reduced, circadian rhythm of blood pressure did not change. 28% had to take diuretics (arifon or hypotiazide). CONCLUSION: Betaloc ZOK (50-100 mg) is highly effective in patients with mild to moderate essential hypertension.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Features of interferon and cytokine production in genital herpes].

The impaired production of INFs and of other cytokines at different stages of their synthesis in patients with genital herpes before and after treatment were shown to reflect the specificity of the immune response in the mentioned pathology. An activation of the cellular and humoral immunity according to the Th1 and Th2 types was observed in patients with genital herpes. The stimulated activity of Th1, B-lymphocytes and of natural killers (NK) as well as suppression of Th2 occurred in the initial treatment stage by acyclovir (10 days), which brought about a positive clinical effect in a majority of cases. A correlation between the IFN status and cytokine profile, on the one hand, and an effect of therapy in genital herpes, on the other hand, was demonstrated. Finally, the monitoring of the IFN and cytokine status in each patient is needed for choosing a treatment scheme and for prognosticating a therapy efficiency.

Acyclovir↗