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Biomedical subjects

V I Potievskaia

Publications and source records attributed to V I Potievskaia.

9 recordsLinked to original sources
PubMed2003

[Hypoxic therapy of arterial hypertension in patients with different variability of arterial pressure].

Sixty two patients with essential hypertension stage II were divided into two groups. 32 patients of group 1 received combined therapy including a course of inhalations of gas hypoxic mixture containing 10% oxygen and conventional medication (ACE inhibitors, beta-blockers, calcium antagonists, diuretics). 30 patients of group 2 (controls) were given medication alone. 24-h monitoring of arterial pressure (AP) and echocardiography suggested that high AP variability (APV) in hypertensive subjects leads to more significant changes in left ventricular and atrial structure and function typical for hypertensive heart. In high VAP, its night values are subnormal while daytime values are high in patients on combined medication and hypoxic therapy. The patients on standard medication had significantly low VAP at night while their daytime VAP tended to decrease. VAP positively correlated with hypertensive load. In high VAP hypoxic and drug therapies are less effective.

Adrenergic beta-Antagonists↗
PubMed2002

[Hemodynamics of the minor circulation in patients with gastroduodenal ulcer on hypoxic therapy].

Adaptation of patients with gastroduodenal ulcer (GDU) to intermittent normobaric hypoxia is effective in the treatment of this disease. Some GDU patients have functional pulmonary hypertension. Single procedure and a course of normobaric hypoxic therapy have no negative effect on pulmonary hemodynamics. Overloading of the right heart in GDU patients does not contraindicate a course of breathing gas hypoxic mixture created by Strelkov's apparatus.

Adult↗
PubMed1994

[The possibilities of using intermittent normobaric hypoxia for treating hypertension patients].

The response to intermittent normobaric hypoxia (INH) created in breathing gas hypoxia mixture (10% oxygen, 90% nitrogen) was evaluated in 123 patients with essential hypertension stage I and II. Hypoxia adaptation effects on central hemodynamics, physical performance, kinetics of oxygen exchange were studied. A pronounced response to INH persistent for 6 months was demonstrated in 80.5% of the patients. The reduction of the arterial pressure resulted from different mechanisms depending on hemodynamic type. Physical performance of the patients rose, oxygen consumption and transport normalized.

Adult↗
PubMedDate not supplied

[Effect of intermittent normobaric hypoxia on dynamics of disease state in patients with hypertension].

Curative effect of intermittent normobaric hypoxia created when breathing in gaseous hypoxic mixture containing 10% of oxygen and 90% of nitrogen has been examined in 41 patients with hypertonic disease. Adaptation to hypoxia has been studied for its effect on the central hemodynamics psychoemotional state and kinetics of oxygen supply of the skin. The pronounced positive effect of treatment was achieved in 70.7% of patients, the arterial pressure decreasing at the expense of different mechanisms depending on the type of blood circulation. Besides, a decrease in the emotional tension of patients and normalization of oxygen consumption and transport were observed.

Adaptation, Physiological↗
PubMedDate not supplied

[The effect of intermittent normobaric hypoxia on oxygen metabolism in hypertonic pilots].

Oxygen tissue metabolism was evaluated in hypertonic pilots in order to draw up an optimal treatment plan. Oxygen metabolism kinetics was determined with the help of transcutaneous polarography and the local ischemic extremity test was applied to measure the O2 utilization efficiency. Breathing mixture of 90% nitrogen and 10% oxygen (GGS-10) was used in therapeutic sessions of intermittent normobaric hypoxia. Results point to the reduced tissue breathing intensity and cell functional energy reserve in hypertonic patients. However, O2 metabolism is much closer to normal in pilots as compared with non-flyers. In pilots, O2 utilization is more intensive, energy supply of cells is higher, O2 transport and utilization are well-balanced, and tissue breathing is less reactive to the hypoxic factor. Dynamic kinetics of O2 metabolism tested post treatment suggested activation of O2 tissue metabolism in the hypertonic pilots rather than O2 transport which was stimulated in non-flyers. In addition, by the end of treatment the pilots were advised to extend the period of breathing GGS-10 leaving the period of air breathing unchanged. Consequently, the pilots were more adaptable to hypoxia than the non-flyers and, therefore, improved O2 tissue metabolism more rapidly.

Adaptation, Physiological↗
PubMedDate not supplied

[The evaluation of the efficacy of adaptation to intermittent normobaric hypoxia as a method for treating hypertension].

Clinical and functional condition was examined for 75 patients with essential hypertension stage I and II who had developed adaptation to normobaric cyclic-fractionated hypoxia. The latter was produced by gas hypoxic mixture (10% oxygen, 90% nitrogen) in its inhalation. A pronounced positive effect of such treatment modality was registered in 86.7% of the patients and persisted for 6 months and more in 84.3%. A normal correlation was achieved of cardiac ejection to peripheral vascular resistance, this reducing arterial pressure. An optimal hemodynamic response arose to the hypoxic effects which also improved psychoemotional status of the patients.

Adaptation, Physiological↗
PubMedDate not supplied

[Mechanisms of therapeutic and preventive effects of adaptation to hypoxia in arterial hypertension].

Data on the effect of adaptation to hypoxia on the cardio-vascular system responses and arterial pressure regulation have been considered. The role of sympathoadrenal system rearrangement in regulation of cardiac output and vascular tension has been analyzed. The data on the possible role of water-salt metabolism changes in a decrease of arterial pressure after long-term effect of hypoxia are presented. It is concluded that hypoxic training is a promising trend of prevention and treatment of arterial hypertension.

Adaptation, Physiological↗