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Biomedical subjects

V I Pronin

Publications and source records attributed to V I Pronin.

52 records · Page 3Linked to original sources
PubMedDate not supplied

[The feeding of patients through the jejunostoma in the early postoperative period after gastrectomy and proximal resection of the stomach].

The authors have analyzed the course and outcome of the early postoperative period in 45 patients with carcinoma of the stomach who had been subjected to gastrectomy and proximal stomach resection. A lower number of postoperative complications, including those with lethal outcomes, earlier normalization of certain important parameters of homeostasis were recorded in the patients with decompressive-feeding jejunostoma established at the final stage of the operation (18 subjects). A variant of the diet based on enpits for feeding through jejunostoma has been presented. No complications associated with the establishment and functioning of the jejunostoma were observed. At the same time the jejunostoma makes possible a rapid diagnosis of certain complications and their conservative treatment without laparotomy. The results of the observation have evidenced that early dosed loading of the digestive tract promotes its more rapid adaptation to new functional conditions.

Enteral Nutrition↗
PubMedDate not supplied

[Prophylactic effect of enteral feeding preparations during the chemotherapy of oncology patients].

Altogether 124 patients were followed up for disseminated breast cancer (82) and hematosarcoma (42). The patients were divided into two groups: the main group was given 500 ml of 20% protein or low-lactose enteral feeding in addition to the hospital diet; the control group received only the hospital diet. Chemotherapy lasted 3 weeks. The patients on chemotherapy received enteral feeding every day throughout the entire treatment period. In the course of treatment, the patients were examined for blood characteristics, size of the tumor and affected lymph nodes, body weight, major metabolism, protein metabolism, vitamin metabolism, osmotic and peroxide resistance of red cells, and liver function. The research program covered more than 150 characteristics. The data obtained were processed by computer. It has been disclosed that inclusion of protein and low-lactose enteral feeding into the diet of cancer patients improves the alimentary status, decreases the leukopenia and thrombocytopenia incidence. It is advisable that specialized milk concentrates (enteral feeding) should be included into the diet of cancer patients as a necessary component of a complex of therapeutic measures used during chemotherapy.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Modes and classes of modes of action of physiologically active substances of receptor type under conditions of screening.

Questions of the identification of the type of pharmacological activity of physiologically active substances (PAS) with a receptor type of action under conditions of screening are examined. IN accordance with current concepts of the theory of the recognition of modes, the type of action of PAS was identified by establishing a set of criteria ("vectors of modes") characteristic of the effect of known substances and by selecting methods of comparing them with the vectors of the modes of the compounds being tested. Test parameters recorded by the the functional multiparametric method permitting identification of the type of the effects and an evaluation of their quantitative manifestations with the framework of a single experimental approach were used as the unknown set of criteria. The method of describing the relative change in the parameters from the dose as the vectors of action was used and the function of proximity (similarity).

Animals↗