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Biomedical subjects

V I Serbin

Publications and source records attributed to V I Serbin.

At least 19 recordsLinked to original sources
PubMed1993

[Disorders of membrane mechanisms in stressor damage to the heart in rats of various strains].

The resistance of the rat's organism to emotional stress is determined by alterations of the heart's electric stability. The condition of lipid oxidation is accompanied by alterations of cholesterol and ionised calcium concentrations. Such alterations were expressed in Fisher rats to a greater extent. It conformed to the morphophysiological peculiarities of this group of animals and confirmed its considerable species sensibility.

Animals↗
PubMed1991

[Clinico-morphological comparison in children with infectious endocarditis].

As many as 21 children suffering from infectious endocarditis (IE) were examined for the clinical and morphological picture of the disease. The patients' age ranged from 2 to 15 years. In 15 children, IE developed in association with different congenital diseases; in one patient, in the presence of rheumatic heart disease, and in 5 patients, in unaffected heart valves. The sectional material was examined in 19 cases whereas the operational material in 2 cases. Analysis of the data obtained has shown that early diagnosis of IE (primary and secondary) may not infrequently be fairly difficult, which is likely to result in the late administration of antibacterial therapy. In addition to the involvement of the valvular apparatus of the heart, the majority of the patients demonstrated the signs of focal myocarditis and postmyocarditic cardiosclerosis, which is one of the causes of the development of refractory heart insufficiency. IE children mostly die from heart insufficiency and thromboembolism.

Adolescent↗
PubMed1991

[ECG changes in hypertrophic cardiomyopathy in children (data of routine and circadian ECG)].

Analysis is made of the routine and circadian ECG in 32 children with hypertrophic cardiomyopathy. The signs of myocardial hypertrophy of some or other parts of the heart were discovered in 29 children (90.6%). The signs of left ventricular hypertrophy were the most suggestive ones, whereas the signs of left atrial hypertrophy and right heart hypertrophy were observed less frequently. The use of the daily ECG monitoring allowed rhythm and conduction disorders to be revealed in 30 children (93.8%). It should be mentioned that in patients with the obstructive form of the disease, the signs of myocardial hypertrophy and heart arrhythmia on the ECG occurred much more often than in children suffering from the non-obstructive form. In accordance with the observations, prognostically unfavourable disorders of heart rhythm are not characteristic of children, they occur rarely, being primarily seen in the obstructive form of the disease. The daily ECG monitoring not infrequently allows the identification of heart arrhythmias and transitory disorders of conduction, which cannot be recorded on routine electrocardiography.

Adolescent↗
PubMed1990

[Arrhythmia in children with dilated cardiomyopathy (data of 24-hour ECG monitoring)].

The authors demonstrate potentialities of long-term ECG monitoring in the diagnosis of heart rhythm and conduction disturbances in children with dilated cardiomyopathy. Provide the results of comparative studies of routine and 24-hour ECG monitoring in children with dilated cardiomyopathy under every-day life conditions. Show that during 24-hour ECG monitoring, all the children with the above pathology manifest heart rhythm and conduction disturbances of varying intensity and prognostic significance.

Adolescent↗
PubMed1990

[Status of the liver in children with cardiomyopathies (data from echographic study)].

In order to estimate the liver status and hemodynamics in children with non-rheumatic cardiomyopathies, 130 schoolchildren were examined. Of these, 60 children were diagnosed to have hypertrophic and 70 dilated cardiomyopathy. In both cardiomyopathy varieties, alterations in the liver were established to be of secondary character and associated with greater circulation abnormalities. The patients manifested an appreciable increase of the diameter of the hepatic veins and reduction in them of the blood flow rate. Adequate cardiotropic therapy brought about a noticeable decrease in the echographic signs of liver congestion.

Adolescent↗
PubMed1989

[Ultrasonic methods of diagnosing infectious endocarditis in children].

Ultrasound research methods were applied in 32 children with the clinical signs of infectious endocarditis (IE). The patients' age varied from 3 to 16 years. In 5 patients, IE turned out primary in the intact valves whereas in 27 patients, it superadded on different congenital heart disease. In 10 patients, IE had developed before surgical correction of the diseases and in 17, within different times after operation. The direct and indirect echo-signs of IE were delineated. The direct echo-signs included vegetations which were discovered in 22 out of the 32 patients. The indirect echo-signs included the signs of regurgitation in the externally unchanged or minimally changed cusps of the valves and blood drop at the level of the ventricles in connection with the defect reshunting in the interventricular septum. The data obtained are in good agreement with the clinical picture, surgical and morbid anatomy data.

Adolescent↗
PubMed1989

[Morphofunctional state of the heart in dilated cardiomyopathy in children].

To study the morphofunctional state of the heart, 49 children aged 1 to 15 years with dilated cardiomyopathy (DCMP) were examined. The diagnosis was established on the basis of comprehensive clinical and instrumental examinations. It was discovered as a result of echocardiography that children with dilated cardiomyopathy show considerable dilatation of the cardiac chambers, accompanied by moderate hypertrophy of the myocardium (mainly of the left ventricle) and by appreciable impairment of the function of myocardial contraction and relaxation together with derangement of heart pump function. The overwhelming majority of patients with DCMP manifested relative failure of the mitral valve which plays an important role in the impairment of intracardiac and central hemodynamics. It should be noted that echographic alterations seen in DCMP are not specific. However, they provide an idea of the gravity of heart damage, that is of importance in outlining the policy of treatment and prophylactic measures.

Adolescent↗